Targeted deletion of Sost distal enhancer increases bone formation and bone mass - Wikidata - wikimedia - TriplyDB

Targeted deletion of Sost distal enhancer increases bone formation and bone mass

Targeted deletion of Sost distal enhancer increases bone formation and bone mass

http://www.wikidata.org/entity/Q36212807

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Sclerostin Inhibition in the Management of Osteoporosis From disease to treatment: from rare skeletal disorders to treatments for osteoporosis Functional anatomy of distant-acting mammalian enhancers Developments in sclerostin biology: regulation of gene expression, mechanisms of action, and physiological functions.Analysis of association of MEF2C, SOST and JAG1 genes with bone mineral density in Mexican-Mestizo postmenopausal women.Interrogating transcriptional regulatory sequences in Tol2-mediated Xenopus transgenics HDAC5 controls MEF2C-driven sclerostin expression in osteocytes.A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice.Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model.SOST Inhibits Prostate Cancer Invasion.Computational Characterization of Osteoporosis Associated SNPs and Genes Identified by Genome-Wide Association Studies Lipoprotein receptor-related protein 6 is required for parathyroid hormone-induced Sost suppression.Sclerostin antibody treatment improves fracture outcomes in a Type I diabetic mouse model.Sclerostin alters serum vitamin D metabolite and fibroblast growth factor 23 concentrations and the urinary excretion of calcium Parathyroid hormone (PTH)/PTH-related peptide type 1 receptor (PPR) signaling in osteocytes regulates anabolic and catabolic skeletal responses to PTH.Cancer-Osteoblast Interaction Reduces Sost Expression in Osteoblasts and Up-Regulates lncRNA MALAT1 in Prostate Cancer.Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner.Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption-formation cycles?Eukaryotic enhancers: common features, regulation, and participation in diseases.The osteocyte plays multiple roles in bone remodeling and mineral homeostasis.Regulation of bone metabolism by Wnt signals.Multiple modes of Lrp4 function in modulation of Wnt/β-catenin signaling during tooth development.Role and mechanism of action of sclerostin in bone.The osteoblast to osteocyte transition: epigenetic changes and response to the vitamin D3 hormone.Analysis of SOST expression using large minigenes reveals the MEF2C binding site in the evolutionarily conserved region (ECR5) enhancer mediates forskolin, but not 1,25-dihydroxyvitamin D3 or TGFβ1 responsiveness.The Microdamage and Expression of Sclerostin in Peri-implant Bone under One-time Shock Force Generated by Impact.MMP-13 is one of the critical mediators of the effect of HDAC4 deletion on the skeleton.A mobile insulator system to detect and disrupt cis-regulatory landscapes in vertebrates.The parathyroid hormone-regulated transcriptome in osteocytes: parallel actions with 1,25-dihydroxyvitamin D3 to oppose gene expression changes during differentiation and to promote mature cell function.Osteogenesis induced by frizzled-related protein (FRZB) is linked to the netrin-like domain.MANAGEMENT OF ENDOCRINE DISEASE: Novel anabolic treatments for osteoporosis.Activating the unfolded protein response in osteocytes causes hyperostosis consistent with craniodiaphyseal dysplasia.Sclerostin: an Emerging Target for the Treatment of Cancer-Induced Bone Disease.SOST/Sclerostin Improves Post Traumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury.CYR61/CCN1 Regulates Sclerostin Levels and Bone Maintenance.Mice with sclerostin gene deletion are resistant to the severe sublesional bone loss induced by spinal cord injury.Treatment with intermittent PTH increases Wnt10b production by T cells in osteoporotic patients.Osterix and RUNX2 are Transcriptional Regulators of Sclerostin in Human Bone.Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin.Parathyroid Hormone Signaling in Osteocytes

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Targeted deletion of Sost distal enhancer increases bone formation and bone mass

http://www.wikidata.org/entity/Q36212807

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

@zh-hans

2012年学术文章

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2012年学术文章

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2012年學術文章

@yue

2012年學術文章

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2012年學術文章

@zh-hant

name

Targeted deletion of Sost distal enhancer increases bone formation and bone mass

@ast

Targeted deletion of Sost distal enhancer increases bone formation and bone mass

@en

type

label

Targeted deletion of Sost distal enhancer increases bone formation and bone mass

@ast

Targeted deletion of Sost distal enhancer increases bone formation and bone mass

@en

prefLabel

Targeted deletion of Sost distal enhancer increases bone formation and bone mass

@ast

Targeted deletion of Sost distal enhancer increases bone formation and bone mass

@en

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PNAS.1207188109

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Targeted deletion of Sost distal enhancer increases bone formation and bone mass

@en

P2093

Gabriela G Loots

http://www.w3.org/2001/XMLSchema#string

LiQin Xie

http://www.w3.org/2001/XMLSchema#string

Mohammad Shahnazari

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Nancy E Lane

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Nicole M Collette

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Richard M Harland

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Wei Yao

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P2860

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

Control of the SOST bone enhancer by PTH using MEF2 transcription factors

Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

Lrp5 functions in bone to regulate bone mass

Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

High bone mass in mice expressing a mutant LRP5 gene

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development

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14092-14097

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scholarly article

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10.1073/PNAS.1207188109

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35

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109

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Aris Economides

Damian C Genetos

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2012-08-10T00:00:00Z

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230657321

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22886088

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3435175

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