Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. - Wikidata - wikimedia - TriplyDB

Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers.

Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers.

http://www.wikidata.org/entity/Q36213486

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Current hypotheses on how microsatellite instability leads to enhanced survival of Lynch Syndrome patients The TES gene at 7q31.1 is methylated in tumours and encodes a novel growth-suppressing LIM domain protein Human exonuclease I is required for 5' and 3' mismatch repair Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability The mismatch repair system is required for S-phase checkpoint activation MethyLight: a high-throughput assay to measure DNA methylation The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16(INK4a) and hMLH1 genes HLTF gene silencing in human colon cancer.Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas Molecular origins of cancer: Molecular basis of colorectal cancer Microsatellite instability in colorectal cancer Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines Somatic frameshift mutations in the Bloom syndrome BLM gene are frequent in sporadic gastric carcinomas with microsatellite mutator phenotype Role of APC and DNA mismatch repair genes in the development of colorectal cancers.The clinical value of aberrant epigenetic changes of DNA damage repair genes in human cancer BRAF mutant colorectal cancer as a distinct subset of colorectal cancer: clinical characteristics, clinical behavior, and response to targeted therapies Lynch syndrome and Lynch syndrome mimics: The growing complex landscape of hereditary colon cancer Opportunities for immunotherapy in microsatellite instable colorectal cancer Biomarkers for immune therapy in colorectal cancer: mismatch-repair deficiency and others Obesity and colorectal cancer: molecular features of adipose tissue Genetics and Genetic Biomarkers in Sporadic Colorectal Cancer Aspirin-induced nuclear translocation of NFkappaB and apoptosis in colorectal cancer is independent of p53 status and DNA mismatch repair proficiency Review article: the chemoprevention of colorectal carcinoma Promoter methylation status of hMLH1, hMSH2, and MGMT genes in colorectal cancer associated with adenoma-carcinoma sequence The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities Microsatellite instability and MLH1 promoter hypermethylation in colorectal cancer Promoter methylation and immunohistochemical expression of hMLH1 and hMSH2 in sporadic colorectal cancer: a study from India Epigenetic downregulation of the DNA repair gene MED1/MBD4 in colorectal and ovarian cancer Humans accumulate microsatellite instability with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of age Mlh1 mediates tissue-specific regulation of mitotic recombination Silencing-specific methylation and single nucleotide polymorphism of hMLH1 promoter in gastric carcinomas.Mutation rates of TGFBR2 and ACVR2 coding microsatellites in human cells with defective DNA mismatch repair.TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer.Role of double-stranded DNA translocase activity of human HLTF in replication of damaged DNA Bisulfite Patch PCR enables multiplexed sequencing of promoter methylation across cancer samples.The mismatch repair system modulates curcumin sensitivity through induction of DNA strand breaks and activation of G2-M checkpoint.

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Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers.

http://www.wikidata.org/entity/Q36213486

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1998年论文

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Biallelic inactivation of hMLH ...... ism causing human MSI cancers.

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Biallelic inactivation of hMLH ...... ism causing human MSI cancers.

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type

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Biallelic inactivation of hMLH ...... ism causing human MSI cancers.

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Biallelic inactivation of hMLH ...... ism causing human MSI cancers.

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Biallelic inactivation of hMLH ...... ism causing human MSI cancers.

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Biallelic inactivation of hMLH ...... nism causing human MSI cancers

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A H Ma

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L Kasturi

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P L Modrich

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S D Markowitz

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S Periyasamy

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W D Sedwick

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P2860

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

Lessons from hereditary colorectal cancer

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

Biochemistry and genetics of eukaryotic mismatch repair

Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

Mismatch repair in replication fidelity, genetic recombination, and cancer biology

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines

Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs

Mutator phenotypes in human colorectal carcinoma cell lines.

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