The role of focal-adhesion kinase in cancer - a new therapeutic opportunity.
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Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibitionKIF14 negatively regulates Rap1a-Radil signaling during breast cancer progressionNuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradationProline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activationThe SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motilityIntegrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor βLung cancer cell migration is regulated via repressing growth factor PTN/RPTP β/ζ signaling by meninOverexpression of macrophage inhibitory cytokine-1 induces metastasis of human prostate cancer cells through the FAK-RhoA signaling pathwayEmerging roles of nodal and Cripto-1: from embryogenesis to breast cancer progressionNitric oxide and peroxynitrite in health and diseaseStructural basis for the autoinhibition of focal adhesion kinaseFAK and paxillin, two potential targets in pancreatic cancerTumor and stromal-based contributions to head and neck squamous cell carcinoma invasionNuclear FAK: a new mode of gene regulation from cellular adhesionsInvolvement of 14-3-3 Proteins in Regulating Tumor Progression of Hepatocellular CarcinomaFAK in cancer: mechanistic findings and clinical applicationsTumor cell migration in complex microenvironmentsNovel Phosphotidylinositol 4,5-Bisphosphate Binding Sites on Focal Adhesion KinaseAltering FAK-paxillin interactions reduces adhesion, migration and invasion processesA photoactivatable nanopatterned substrate for analyzing collective cell migration with precisely tuned cell-extracellular matrix ligand interactionsThe proteomic landscape of triple-negative breast cancer.Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferationFAK dimerization controls its kinase-dependent functions at focal adhesionsDasatinib sensitizes KRAS mutant colorectal tumors to cetuximabThe heterochronic microRNA let-7 inhibits cell motility by regulating the genes in the actin cytoskeleton pathway in breast cancerLatest developments in our understanding of the pathogenesis of mesothelioma and the design of targeted therapiesThe role of proline rich tyrosine kinase 2 (Pyk2) on cisplatin resistance in hepatocellular carcinomaSrc-dependent phosphorylation of ASAP1 regulates podosomes.miR-151-3p Targets TWIST1 to Repress Migration of Human Breast Cancer CellsDiscovery of novel focal adhesion kinase inhibitors using a hybrid protocol of virtual screening approach based on multicomplex-based pharmacophore and molecular dockingmiRNA-mRNA correlation-network modules in human prostate cancer and the differences between primary and metastatic tumor subtypesSpecific oncogenic activity of the Src-family tyrosine kinase c-Yes in colon carcinoma cells.Activation of focal adhesion kinase through an interaction with β4 integrin contributes to tumorigenicity of colon cancerRhoC Promotes Metastasis via Activation of the Pyk2 Pathway in Prostate CancerA Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region.FAK competes for Src to promote migration against invasion in melanoma cells.Global gene expression analysis identifies PDEF transcriptional networks regulating cell migration during cancer progressionFAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells.Paxillin enables attachment-independent tyrosine phosphorylation of focal adhesion kinase and transformation by RAS.Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion.
P2860
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P2860
The role of focal-adhesion kinase in cancer - a new therapeutic opportunity.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
The role of focal-adhesion kinase in cancer - a new therapeutic opportunity.
@ast
The role of focal-adhesion kinase in cancer - a new therapeutic opportunity.
@en
type
label
The role of focal-adhesion kinase in cancer - a new therapeutic opportunity.
@ast
The role of focal-adhesion kinase in cancer - a new therapeutic opportunity.
@en
prefLabel
The role of focal-adhesion kinase in cancer - a new therapeutic opportunity.
@ast
The role of focal-adhesion kinase in cancer - a new therapeutic opportunity.
@en
P2093
P356
P1476
The role of focal-adhesion kinase in cancer - a new therapeutic opportunity.
@en
P2093
Egle Avizienyte
Gordon W McLean
Jeff Evans
Valerie G Brunton
P2888
P304
P356
10.1038/NRC1647
P407
P577
2005-07-01T00:00:00Z