The insulin-like growth factor-I receptor as a target for cancer therapy.
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Methodology for Anti-Gene Anti-IGF-I Therapy of Malignant TumoursIdentification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptorHeterodimerization of glycosylated insulin-like growth factor-1 receptors and insulin receptors in cancer cells sensitive to anti-IGF1R antibodyRILM: a web-based resource to aid comparative and functional analysis of the insulin and IGF-1 receptor family.Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma.A phase Ib study of linsitinib (OSI-906), a dual inhibitor of IGF-1R and IR tyrosine kinase, in combination with everolimus as treatment for patients with refractory metastatic colorectal cancer.Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605.Basic and clinical significance of IGF-I-induced signatures in cancerSequence-specific targeting of IGF-I and IGF-IR genes by camptothecinsA phase 1, open-label, dose-escalation study of BIIB022 (anti-IGF-1R monoclonal antibody) in subjects with relapsed or refractory solid tumorsThe type I insulin-like growth factor receptor regulates cancer metastasis independently of primary tumor growth by promoting invasion and survival.Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approachSmall interfering RNA targeted to IGF-IR delays tumor growth and induces proinflammatory cytokines in a mouse breast cancer modelTyrosine kinase pathways modulate tumor susceptibility to natural killer cellsSomething old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulationTargeting insulin-like growth factor pathways.Common genetic polymorphisms and prognosis of sporadic cancers: prostate cancer as a model.Toward a core nutraceutical program for cancer management.β-Arrestin-biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor-targeting antibodies in Ewing's sarcoma.Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitorsOverexpression of Insulin-like Growth Factor-1 Receptor Is Associated With Penile Cancer Progression.Igf1r as a therapeutic target in a mouse model of basal-like breast cancerEwing sarcoma: prognostic criteria, outcomes and future treatment.Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody.Customizing the targeting of IGF-1 receptor.Targeting the IGF1 axis in cancer proliferation.Depletion of insulin receptor substrate 2 reverses oncogenic transformation induced by v-src.Molecular targeted therapy in ovarian cancer: what is on the horizon?Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy.The decline and fall of the IGF-I receptor.Malignant glioma drug discovery - targeting protein kinases.Downregulation of IGFBP2 is associated with resistance to IGF1R therapy in rhabdomyosarcoma.Treatment of biliary tract cancer with NVP-AEW541: mechanisms of action and resistance.Insulin-like growth factor-1 receptor and ErbB kinase inhibitor combinations block proliferation and induce apoptosis through cyclin D1 reduction and Bax activation.The mechanism of hydralazine-induced collagen biosynthesis in cultured fibroblastsThe mechanism of oxythiamine-induced collagen biosynthesis in cultured fibroblasts.Insulin receptor substrate (IRS)-1 regulates murine embryonic stem (mES) cells self-renewal.Progression to metastatic stage in a cellular model of prostate cancer is associated with methylation of the androgen receptor gene and transcriptional suppression of the insulin-like growth factor-I receptor gene.Emerging drugs for head and neck cancer.Expression and significance of IGF-1 and IGF-1R in thyroid nodules.
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P2860
The insulin-like growth factor-I receptor as a target for cancer therapy.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
The insulin-like growth factor-I receptor as a target for cancer therapy.
@ast
The insulin-like growth factor-I receptor as a target for cancer therapy.
@en
type
label
The insulin-like growth factor-I receptor as a target for cancer therapy.
@ast
The insulin-like growth factor-I receptor as a target for cancer therapy.
@en
prefLabel
The insulin-like growth factor-I receptor as a target for cancer therapy.
@ast
The insulin-like growth factor-I receptor as a target for cancer therapy.
@en
P2860
P356
P1476
The insulin-like growth factor-I receptor as a target for cancer therapy.
@en
P2093
Renato Baserga
P2860
P304
P356
10.1517/14728222.9.4.753
P407
P577
2005-08-01T00:00:00Z