Structural and functional consequences of the cardiac troponin C L48Q Ca(2+)-sensitizing mutation.
about
Gene regulation, alternative splicing, and posttranslational modification of troponin subunits in cardiac development and adaptation: a focused reviewMolecular mechanisms of disease-causing missense mutationsMolecular basis of calcium-sensitizing and desensitizing mutations of the human cardiac troponin C regulatory domain: a multi-scale simulation studyRationally engineered Troponin C modulates in vivo cardiac function and performance in health and diseaseThin filament incorporation of an engineered cardiac troponin C variant (L48Q) enhances contractility in intact cardiomyocytes from healthy and infarcted hearts.Molecular determinants of cardiac myocyte performance as conferred by isoform-specific TnI residuesIn situ time-resolved FRET reveals effects of sarcomere length on cardiac thin-filament activation.PKA phosphorylation of cardiac troponin I modulates activation and relaxation kinetics of ventricular myofibrils.Computational studies of the effect of the S23D/S24D troponin I mutation on cardiac troponin structural dynamics.Effects of HCM cTnI mutation R145G on troponin structure and modulation by PKA phosphorylation elucidated by molecular dynamics simulationsTroponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation.Enhanced Ca2+ binding of cardiac troponin reduces sarcomere length dependence of contractile activation independently of strong crossbridges.Long-timescale molecular dynamics simulations elucidate the dynamics and kinetics of exposure of the hydrophobic patch in troponin CMolecular Basis of S100A1 Activation at Saturating and Subsaturating Calcium Concentrations.Structural and functional consequences of cardiac troponin C L57Q and I61Q Ca(2+)-desensitizing variantsA Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy.Effects of Cardiac Troponin I Mutation P83S on Contractile Properties and the Modulation by PKA-Mediated Phosphorylation.Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility.Changes in the dynamics of the cardiac troponin C molecule explain the effects of Ca2+-sensitizing mutations.The structural and functional effects of the familial hypertrophic cardiomyopathy-linked cardiac troponin C mutation, L29QMolecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation-An Integrated Multiscale Modeling Study.
P2860
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P2860
Structural and functional consequences of the cardiac troponin C L48Q Ca(2+)-sensitizing mutation.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Structural and functional cons ...... Q Ca(2+)-sensitizing mutation.
@ast
Structural and functional cons ...... Q Ca(2+)-sensitizing mutation.
@en
type
label
Structural and functional cons ...... Q Ca(2+)-sensitizing mutation.
@ast
Structural and functional cons ...... Q Ca(2+)-sensitizing mutation.
@en
prefLabel
Structural and functional cons ...... Q Ca(2+)-sensitizing mutation.
@ast
Structural and functional cons ...... Q Ca(2+)-sensitizing mutation.
@en
P2093
P2860
P356
P1433
P1476
Structural and functional cons ...... Q Ca(2+)-sensitizing mutation.
@en
P2093
Brian D Sykes
Ian M Robertson
Melissa L Crane
Michael Regnier
Michelle E McCully
Monica X Li
Zhaoxiong Luo
P2860
P304
P356
10.1021/BI3003007
P407
P577
2012-05-23T00:00:00Z