Third target of rapamycin complex negatively regulates development of quiescence in Trypanosoma brucei. - Wikidata - wikimedia - TriplyDB

Third target of rapamycin complex negatively regulates development of quiescence in Trypanosoma brucei.

Third target of rapamycin complex negatively regulates development of quiescence in Trypanosoma brucei.

http://www.wikidata.org/entity/Q36221669

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Kinases as druggable targets in trypanosomatid protozoan parasites Assembling the components of the quorum sensing pathway in African trypanosomes Revisiting the central metabolism of the bloodstream forms of Trypanosoma brucei: production of acetate in the mitochondrion is essential for parasite viability Regulators of Trypanosoma brucei cell cycle progression and differentiation identified using a kinome-wide RNAi screen Quantitative Proteomics Uncovers Novel Factors Involved in Developmental Differentiation of Trypanosoma brucei Trypanosoma brucei FKBP12 differentially controls motility and cytokinesis in procyclic and bloodstream forms.SCF(FBXW7α) modulates the intra-S-phase DNA-damage checkpoint by regulating Polo like kinase-1 stability The design and synthesis of potent and selective inhibitors of Trypanosoma brucei glycogen synthase kinase 3 for the treatment of human african trypanosomiasis.Independent pathways can transduce the life-cycle differentiation signal in Trypanosoma brucei.Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei.Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2.Global quantitative SILAC phosphoproteomics reveals differential phosphorylation is widespread between the procyclic and bloodstream form lifecycle stages of Trypanosoma brucei.Bloodstream form pre-adaptation to the tsetse fly in Trypanosoma brucei.The AMPKα1 Pathway Positively Regulates the Developmental Transition from Proliferation to Quiescence in Trypanosoma brucei.High-throughput chemical screening for antivirulence developmental phenotypes in Trypanosoma brucei.Tracking autophagy during proliferation and differentiation of Trypanosoma brucei.Starvation-response may not involve Atg1-dependent autophagy induction in non-unikont parasites.Chromatin modifications in trypanosomes due to stress.The DRBD13 RNA binding protein is involved in the insect-stage differentiation process of Trypanosoma brucei.The within-host dynamics of African trypanosome infections.The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth Metabolic reprogramming during the Trypanosoma brucei life cycle.Detection and treatment of Trypanosoma cruzi: a patent review (2011-2015).βTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy.AMPK in Pathogens.The Cytological Events and Molecular Control of Life Cycle Development of Trypanosoma brucei in the Mammalian Bloodstream.Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei.RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse.Target of rapamycin (TOR) kinase in Trypanosoma brucei: an extended family.Evolutionary Conservation of the Components in the TOR Signaling Pathways.The regulation of autophagy differentially affects Trypanosoma cruzi metacyclogenesis.Inositol polyphosphate multikinase regulation of Trypanosoma brucei life stage development.RNA-Seq analysis validates the use of culture-derived Trypanosoma brucei and provides new markers for mammalian and insect life-cycle stages.Emerging challenges in understanding trypanosome antigenic variation Non-linear hierarchy of the quorum sensing signalling pathway in bloodstream form African trypanosomes

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P2860

Third target of rapamycin complex negatively regulates development of quiescence in Trypanosoma brucei.

http://www.wikidata.org/entity/Q36221669

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2012 nî lūn-bûn

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Third target of rapamycin comp ...... escence in Trypanosoma brucei.

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Proceedings of the National Academy of Sciences of the United States of America

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Third target of rapamycin comp ...... escence in Trypanosoma brucei.

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Antonio Barquilla

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Enrique Calvo

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Isabel Vidal

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Michael N Hall

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Rosario Diaz

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P2860

The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

Cold shock and regulation of surface protein trafficking convey sensitization to inducers of stage differentiation in Trypanosoma brucei

A surface transporter family conveys the trypanosome differentiation signal

Molecular organization of target of rapamycin complex 2.

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

Vaults and the major vault protein: novel roles in signal pathway regulation and immunity

Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation

Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell

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109

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Jean-Mathieu Bart

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Trypanosoma brucei

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