Characterization of dominant and recessive assembly-defective mutations in mouse neurofilament NF-M.
about
A human keratin 14 "knockout": the absence of K14 leads to severe epidermolysis bullosa simplex and a function for an intermediate filament proteinEpithelial V-like antigen (EVA), a novel member of the immunoglobulin superfamily, expressed in embryonic epithelia with a potential role as homotypic adhesion molecule in thymus histogenesisGenetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severityThe function of intermediate filaments in cell shape and cytoskeletal integrityPKN associates and phosphorylates the head-rod domain of neurofilament proteinAssembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunitPersyn, a member of the synuclein family, influences neurofilament network integrityTwo distinct functions of the carboxyl-terminal tail domain of NF-M upon neurofilament assembly: cross-bridge formation and longitudinal elongation of filamentsEpidermolysis bullosa simplex-type mutations alter the dynamics of the keratin cytoskeleton and reveal a contribution of actin to the transport of keratin subunits.Steady state dynamics of intermediate filament networks.The importance of intramolecular ion pairing in intermediate filamentsTruncated desmin in PtK2 cells induces desmin-vimentin-cytokeratin coprecipitation, involution of intermediate filament networks, and nuclear fragmentation: a model for many degenerative diseases.Specific interaction of HTLV tax protein and a human type IV neuronal intermediate filament proteinDeletions in epidermal keratins leading to alterations in filament organization in vivo and in intermediate filament assembly in vitroEctopic synthesis of epidermal cytokeratins in pancreatic islet cells of transgenic mice interferes with cytoskeletal order and insulin production.Neurofilaments are obligate heteropolymers in vivo.Intermediate filaments and disease: mutations that cripple cell strength.Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons.Differential organization of desmin and vimentin in muscle is due to differences in their head domains.NuMA is required for the proper completion of mitosis.Do the ends justify the mean? Proline mutations at the ends of the keratin coiled-coil rod segment are more disruptive than internal mutationsThe roles of K5 and K14 head, tail, and R/K L L E G E domains in keratin filament assembly in vitro.The rod domain of NF-L determines neurofilament architecture, whereas the end domains specify filament assembly and network formationAn amino-terminal tetrapeptide specifies cotranslational degradation of beta-tubulin but not alpha-tubulin mRNAs.Dynamics of the neuronal intermediate filaments.Splice site, frameshift, and chimeric GFAP mutations in Alexander diseaseAssembly properties of lamprey neurofilament subunits and their expression after spinal cord transection.The regulation of neurofilament protein dynamics by phosphorylation: clues to neurofibrillary pathobiology.Plasticin, a type III neuronal intermediate filament protein, assembles as an obligate heteropolymer: implications for axonal flexibility.Polyglutamine domain proteins with expanded repeats bind neurofilament, altering the neurofilament network.Determinants for intracellular sorting of cytoplasmic and nuclear intermediate filaments.Assembly of type IV neuronal intermediate filaments in nonneuronal cells in the absence of preexisting cytoplasmic intermediate filaments.Desmin/vimentin intermediate filaments are dispensable for many aspects of myogenesis.A potential role for the COOH-terminal domain in the lateral packing of type III intermediate filamentsSubunit composition of neurofilaments specifies axonal diameter.A synthetic peptide representing the consensus sequence motif at the carboxy-terminal end of the rod domain inhibits intermediate filament assembly and disassembles preformed filaments.Differential dynamics of neurofilament-H protein and neurofilament-L protein in neurons.Intermediate filaments formed de novo from tail-less cytokeratins in the cytoplasm and in the nucleus.
P2860
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P2860
Characterization of dominant and recessive assembly-defective mutations in mouse neurofilament NF-M.
description
1990 nî lūn-bûn
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1990年の論文
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1990年学术文章
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1990年学术文章
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1990年学术文章
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1990年學術文章
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name
Characterization of dominant a ...... s in mouse neurofilament NF-M.
@ast
Characterization of dominant a ...... s in mouse neurofilament NF-M.
@en
type
label
Characterization of dominant a ...... s in mouse neurofilament NF-M.
@ast
Characterization of dominant a ...... s in mouse neurofilament NF-M.
@en
prefLabel
Characterization of dominant a ...... s in mouse neurofilament NF-M.
@ast
Characterization of dominant a ...... s in mouse neurofilament NF-M.
@en
P2860
P356
P1476
Characterization of dominant a ...... s in mouse neurofilament NF-M.
@en
P2093
D W Cleveland
P2860
P304
P356
10.1083/JCB.111.5.1987
P407
P433
P577
1990-11-01T00:00:00Z