Subunit composition of neurofilaments specifies axonal diameter.
about
NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growthA new variant of Charcot-Marie-Tooth disease type 2 is probably the result of a mutation in the neurofilament-light gene.Dysfunctions of neuronal and glial intermediate filaments in diseaseGene targeting studies begin to reveal the function of neurofilament proteinsRequirement of heavy neurofilament subunit in the development of axons with large calibersPeripherin immunoreactivity labels small diameter vestibular 'bouton' afferents in rodentsDisruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunitsAbsence of the mid-sized neurofilament subunit decreases axonal calibers, levels of light neurofilament (NF-L), and neurofilament contentNeurofilaments form a highly stable stationary cytoskeleton after reaching a critical level in axons.Differential expression of cytoskeletal genes in the cochlear nucleus.Arrival, reversal, and departure of neurofilaments at the tips of growing axons.Herpes simplex virus-mediated expression of the axonal protein tau in human model neurons (NT2-N cells).The polymer brush model of neurofilament projections: effect of protein composition.Neuronal and glia-related biomarkers in cerebrospinal fluid of patients with acute ischemic stroke.Desmin aggregate formation by R120G alphaB-crystallin is caused by altered filament interactions and is dependent upon network status in cellsStabilization of neuronal connections and the axonal cytoskeleton.The role of stretching in slow axonal transport.A novel recessive Nefl mutation causes a severe, early-onset axonal neuropathy.Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: neuropathology and behavioral deficits in single- and double-null mice.Expressing hNF-LE397K results in abnormal gaiting in a transgenic model of CMT2EExpansion of neurofilament medium C terminus increases axonal diameter independent of increases in conduction velocity or myelin thickness.Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transportAntagonistic roles of neurofilament subunits NF-H and NF-M against NF-L in shaping dendritic arborization in spinal motor neurons.Neurofilament-dependent radial growth of motor axons and axonal organization of neurofilaments does not require the neurofilament heavy subunit (NF-H) or its phosphorylation.The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate.Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport.Local control of neurofilament accumulation during radial growth of myelinating axons in vivo. Selective role of site-specific phosphorylationMice lacking complex gangliosides develop Wallerian degeneration and myelination defects.Pathomechanisms of mutant proteins in Charcot-Marie-Tooth disease.Interplay between liquid crystalline and isotropic gels in self-assembled neurofilament networksConformational properties of interacting neurofilaments: Monte Carlo simulations of cylindrically grafted apposing neurofilament brushes.RE1 silencing transcription factor is involved in regulating neuron-specific expression of alpha-internexin and neurofilament genes.The mitochondrial connection in auditory neuropathy.Evidence Favoring a Positive Feedback Loop for Physiologic Auto Upregulation of hnRNP-E1 during Prolonged Folate Deficiency in Human Placental Cells.Lessons from Animal Models of Cytoplasmic Intermediate Filament Proteins.The stability of the nuclear lamina polymer changes with the composition of lamin subtypes according to their individual binding strengths.Polyglutamine domain proteins with expanded repeats bind neurofilament, altering the neurofilament network.Coordinate induction of the three neurofilament genes by the Brn-3a transcription factor.Partial peripheral motor nerve lesions induce changes in the conduction properties of remaining intact motoneurons.Cyto- and chemoarchitecture of the cortex of the tammar wallaby (Macropus eugenii): areal organization.
P2860
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P2860
Subunit composition of neurofilaments specifies axonal diameter.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Subunit composition of neurofilaments specifies axonal diameter.
@en
type
label
Subunit composition of neurofilaments specifies axonal diameter.
@en
prefLabel
Subunit composition of neurofilaments specifies axonal diameter.
@en
P2093
P2860
P50
P356
P1476
Subunit composition of neurofilaments specifies axonal diameter
@en
P2093
P2860
P304
P356
10.1083/JCB.133.5.1061
P407
P577
1996-06-01T00:00:00Z