Functional mapping of SPARC: peptides from two distinct Ca+(+)-binding sites modulate cell shape
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Cleavage of the matricellular protein SPARC by matrix metalloproteinase 3 produces polypeptides that influence angiogenesisThe extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptorsMultiple integrins mediate cell attachment to cytotactin/tenascinSPARC, a matricellular glycoprotein with important biological functionsSPARC mediates Src-induced disruption of actin cytoskeleton via inactivation of small GTPases Rho-Rac-Cdc42Development of Secreted Protein and Acidic and Rich in Cysteine (SPARC) Targeted Nanoparticles for the Prognostic Molecular Imaging of Metastatic Prostate Cancer.IFATS collection: Combinatorial peptides identify alpha5beta1 integrin as a receptor for the matricellular protein SPARC on adipose stromal cells.Increased expression of osteonectin/SPARC mRNA and protein in age-related human cataracts and spatial expression in the normal human lens.miR-29 suppression of osteonectin in osteoblasts: regulation during differentiation and by canonical Wnt signalingOsteonectin/SPARC secreted by RPE and localized to the outer plexiform layer of the monkey retina.Basement membrane proteins: structure, assembly, and cellular interactions.Modulation of endothelial cell adhesion by hevin, an acidic protein associated with high endothelial venules.Expression of SPARC during development of the chicken chorioallantoic membrane: evidence for regulated proteolysis in vivo.Interaction of recombinant myocilin with the matricellular protein SPARC: functional implicationsAnti-cancer role of SPARC, an inhibitor of adipogenesisSPARC (secreted protein acidic and rich in cysteine) regulates endothelial cell shape and barrier function.Revisiting the matricellular concept.A peptide of SPARC interferes with the interaction between caspase8 and Bcl2 to resensitize chemoresistant tumors and enhance their regression in vivoDeletion of the SPARC acidic domain or EGF-like module reduces SPARC-induced migration and signaling through p38 MAPK/HSP27 in glioma.SPARC is expressed by mesangial cells in experimental mesangial proliferative nephritis and inhibits platelet-derived-growth-factor-medicated mesangial cell proliferation in vitro.Concepts of osteoblast growth and differentiation: basis for modulation of bone cell development and tissue formation.Secreted Protein Acidic and Rich in Cysteine in Ocular TissueSPARC Regulates Transforming Growth Factor Beta Induced (TGFBI) Extracellular Matrix Deposition and Paclitaxel Response in Ovarian Cancer Cells.SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway.SPARC is a source of copper-binding peptides that stimulate angiogenesis.Developmental control of transcription of a retina-specific gene, QR1, during differentiation: involvement of factors from the POU familyCloning and expression of murine SC1, a gene product homologous to SPARC.Primary mesenchymal cells isolated from SPARC-null mice exhibit altered morphology and rates of proliferation.The Caenorhabditis elegans homologue of the extracellular calcium binding protein SPARC/osteonectin affects nematode body morphology and mobility.The Ca2(+)-binding glycoprotein SPARC modulates cell cycle progression in bovine aortic endothelial cells.Advanced pancreatic ductal adenocarcinoma - Complexities of treatment and emerging therapeutic options.Diverse biological functions of the SPARC family of proteins.Functional morphometric analysis in cellular behaviors: shape and size matter.Molecular mechanisms underlying the divergent roles of SPARC in human carcinogenesis.Extracellular matrix-associated protein Sc1 is not essential for mouse development.Identification of a sequence in the matricellular protein SPARC that interacts with the scavenger receptor stabilin-1.Proteolytic Isoforms of SPARC Induce Adipose Stromal Cell Mobilization in Obesity.Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin.Differential modulation of cell adhesion by interaction between adhesive and counter-adhesive proteins: characterization of the binding of vitronectin to osteonectin (BM40, SPARC).The copper binding domain of SPARC mediates cell survival in vitro via interaction with integrin beta1 and activation of integrin-linked kinase.
P2860
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P2860
Functional mapping of SPARC: peptides from two distinct Ca+(+)-binding sites modulate cell shape
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Functional mapping of SPARC: p ...... ding sites modulate cell shape
@ast
Functional mapping of SPARC: p ...... ding sites modulate cell shape
@en
type
label
Functional mapping of SPARC: p ...... ding sites modulate cell shape
@ast
Functional mapping of SPARC: p ...... ding sites modulate cell shape
@en
prefLabel
Functional mapping of SPARC: p ...... ding sites modulate cell shape
@ast
Functional mapping of SPARC: p ...... ding sites modulate cell shape
@en
P2860
P356
P1476
Functional mapping of SPARC: p ...... ding sites modulate cell shape
@en
P2093
P2860
P304
P356
10.1083/JCB.111.6.3065
P407
P433
P577
1990-12-01T00:00:00Z