Mutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylation
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The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramersThe complexity of epigenetic diseasesDNMT3A and TET2 in the Pre-Leukemic Phase of Hematopoietic DisordersEpigenetic Guardian: A Review of the DNA Methyltransferase DNMT3A in Acute Myeloid Leukaemia and Clonal Haematopoiesis.DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodelingRapid detection of DNMT3A R882 mutations in hematologic malignancies using a novel bead-based suspension assay with BNA(NC) probesDifferential Analysis of Genetic, Epigenetic, and Cytogenetic Abnormalities in AMLDifferential methylation in CN-AML preferentially targets non-CGI regions and is dictated by DNMT3A mutational status and associated with predominant hypomethylation of HOX genes.DNMT3A in haematological malignancies.Exposure to low-dose (56)Fe-ion radiation induces long-term epigenetic alterations in mouse bone marrow hematopoietic progenitor and stem cells.Quantitative detection of DNMT3A R882H mutation in acute myeloid leukemiaDNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation.Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development.DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells.Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model.Epigenetic alterations in hematopoietic malignancies.Origins of aberrant DNA methylation in acute myeloid leukemia.Regulatory variation: an emerging vantage point for cancer biology.Acute myeloid leukemia with DNMT3A mutations.A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells.Epigenetic alterations in acute myeloid leukemias.DNMT3A: the DioNysian MonsTer of acute myeloid leukaemia.Epigenetics in T-cell acute lymphoblastic leukemia.Cooperative DNA binding and protein/DNA fiber formation increases the activity of the Dnmt3a DNA methyltransferasePerspectives for therapeutic targeting of gene mutations in acute myeloid leukaemia with normal cytogenetics.Genetic mutations in epigenetic modifiers as therapeutic targets in acute myeloid leukemia.Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property, a requisite of leukemia initiation and relapse.Driver mutations of cancer epigenomes.Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation.Genetic and epigenetic heterogeneity in acute myeloid leukemia.DNMT3A in Leukemia.DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia.Epigenetic Toxicity of Trichloroethylene: A Single-Molecule Perspective.ASXL1 and DNMT3A mutation in a cytogenetically normal B3 thymomaLandmark analysis of DNMT3A mutations in hematological malignancies.Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers.Emerging therapeutic targets in myeloproliferative neoplasms and peripheral T-cell leukemia and lymphomas.Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies.FLT3-ITD, NPM1, and DNMT3A Gene Mutations and Risk Factors in Normal Karyotype Acute Myeloid Leukemia and Myelodysplastic Syndrome Patients in Upper Northern ThailandAcute myeloid leukaemia.
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P2860
Mutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylation
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Mutations in DNA methyltransfe ...... disrupt processive methylation
@ast
Mutations in DNA methyltransfe ...... disrupt processive methylation
@en
type
label
Mutations in DNA methyltransfe ...... disrupt processive methylation
@ast
Mutations in DNA methyltransfe ...... disrupt processive methylation
@en
prefLabel
Mutations in DNA methyltransfe ...... disrupt processive methylation
@ast
Mutations in DNA methyltransfe ...... disrupt processive methylation
@en
P2093
P2860
P356
P1476
Mutations in DNA methyltransfe ...... disrupt processive methylation
@en
P2093
Celeste Holz-Schietinger
Doug M Matje
Norbert O Reich
P2860
P304
30941-30951
P356
10.1074/JBC.M112.366625
P407
P577
2012-06-21T00:00:00Z