Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. - Wikidata - wikimedia - TriplyDB

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin.

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin.

http://www.wikidata.org/entity/Q36228304

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Oral high-dose atorvastatin treatment in relapsing-remitting multiple sclerosis LXR-dependent and -independent effects of oxysterols on immunity and tumor growth Regulation of Adaptive Immunity in Health and Disease by Cholesterol Metabolism Statin therapy and autoimmune disease: from protein prenylation to immunomodulation Residual beta cell function in newly diagnosed type 1 diabetes after treatment with atorvastatin: the Randomized DIATOR Trial Activation of PPAR-γ and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells.A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals.Augmented reduction of islet β-cell mass in Goto-Kakizaki rats fed high-fat diet and its suppression by pitavastatin treatment.Statin treatment and mortality in bacterial infections--a systematic review and meta-analysis Therapeutic potential of statins in multiple sclerosis: immune modulation, neuroprotection and neurorepair.A tagging-via-substrate approach to detect the farnesylated proteome using two-dimensional electrophoresis coupled with Western blotting Statin-induced Krüppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses.Isoprenoids, small GTPases and Alzheimer's disease.Statins reduce endothelial cell apoptosis via inhibition of TRAIL expression on activated CD4 T cells in acute coronary syndrome.Chimeric anti-staphylococcal enterotoxin B antibodies and lovastatin act synergistically to provide in vivo protection against lethal doses of SEB.Failure of oral atorvastatin to modulate a murine model of systemic lupus erythematosus.Immunomodulatory synergy by combination of atorvastatin and glatiramer acetate in treatment of CNS autoimmunity.Nuclear hormone receptors put immunity on sterols.Molecular mechanisms underlying the effects of statins in the central nervous system.Atorvastatin upregulates regulatory T cells and reduces clinical disease activity in patients with rheumatoid arthritis.Modulation of dendritic cell immunobiology via inhibition of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase.Farnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance Randomized controlled trial of atorvastatin in clinically isolated syndrome: the STAyCIS study Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis Tipifarnib-mediated suppression of T-bet-dependent signaling pathways.Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis.Lovastatin blocks Kv1.3 channel in human T cells: a new mechanism to explain its immunomodulatory properties Transcriptional regulation of T cell metabolism.Atorvastatin for the Prophylaxis of Acute Graft-versus-Host Disease in Patients Undergoing HLA-Matched Related Donor Allogeneic Hematopoietic Stem Cell Transplantation (allo-HCT).Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity Obeticholic acid, a synthetic bile acid agonist of the farnesoid X receptor, attenuates experimental autoimmune encephalomyelitis.Evaluation of atorvastatin and simvastatin for treatment of multiple sclerosis.In vivo effect of statins on the expression of the HIV co-receptors CCR5 and CXCR4 Combined medication of lovastatin with rolipram suppresses severity of experimental autoimmune encephalomyelitis.mTOR and lymphocyte metabolism.Potential therapeutic role of statins in neurological disorders.A Journey in Science: The Privilege of Exploring the Brain and the Immune System.The IFN-gamma-induced transcriptional program of the CIITA gene is inhibited by statins.Hyperlipidemia and statin use after allogeneic hematopoietic stem cell transplantation.T helper cell polarization in healthy people: implications for cardiovascular disease

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P2860

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin.

http://www.wikidata.org/entity/Q36228304

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2006 nî lūn-bûn

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Isoprenoids determine Th1/Th2 ...... autoimmunity by atorvastatin.

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Isoprenoids determine Th1/Th2 ...... autoimmunity by atorvastatin.

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Isoprenoids determine Th1/Th2 ...... autoimmunity by atorvastatin.

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Isoprenoids determine Th1/Th2 ...... autoimmunity by atorvastatin.

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Isoprenoids determine Th1/Th2 ...... autoimmunity by atorvastatin.

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Isoprenoids determine Th1/Th2 ...... autoimmunity by atorvastatin.

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Isoprenoids determine Th1/Th2 ...... autoimmunity by atorvastatin.

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Lawrence Steinman

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Martin S Weber

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Matthew J Goldstein

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Sawsan Youssef

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Scott S Zamvil

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Shannon E Dunn

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Thomas Prod'homme

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P2860

Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase

Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models

Lovastatin inhibits G1/S transition of normal human B-lymphocytes independent of apoptosis

Regulation of the mevalonate pathway

Protein prenylation: molecular mechanisms and functional consequences

Incorporation of radiolabeled prenyl alcohols and their analogs into mammalian cell proteins. A useful tool for studying protein prenylation.

Non-lipid-related effects of statins.

Reprogramming transcription during the differentiation of precursor CD4+ T cells into effector Th1 and Th2 cells.

Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1.

Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial.

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