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HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalphaMetnase mediates resistance to topoisomerase II inhibitors in breast cancer cellsHyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells(-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerasesBioflavonoids as poisons of human topoisomerase II alpha and II betaDietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancementDNA Damage Response and Immune Defense: Links and MechanismsGenotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cellsMechanism of repair of 5′-topoisomerase II–DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2Molecular and Pharmacologic Properties of the Anticancer Quinolone Derivative Vosaroxin: A New Therapeutic Agent for Acute Myeloid LeukemiaThe broken genome: genetic and pharmacologic approaches to breaking DNAVoreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase IIIdentification of BC005512 as a DNA damage responsive murine endogenous retrovirus of GLN family involved in cell growth regulationThe broken MLL gene is frequently located outside the inherent chromosome territory in human lymphoid cells treated with DNA topoisomerase II poison etoposideNon-antioxidant properties of α-tocopherol reduce the anticancer activity of several protein kinase inhibitors in vitroPreferential Fas-mediated apoptotic execution at G1 phase: the resistance of mitotic cells to the cell deathAccurate mass-time tag library for LC/MS-based metabolite profiling of medicinal plantsHyperphosphorylation of replication protein A in cisplatin-resistant and -sensitive head and neck squamous cell carcinoma cell linesTargeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function.Analysis of illegitimate genomic integration mediated by zinc-finger nucleases: implications for specificity of targeted gene correctionA novel aminosteroid of the 5α-androstane-3α,17β-diol family induces cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells.alphaB-crystallin is mutant B-RAF regulated and contributes to cyclin D1 turnover in melanocytic cells.Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme.Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate.Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405.The use of divalent metal ions by type II topoisomerases.DNA break mapping reveals topoisomerase II activity genome-wide.BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy responseUpregulation of miR-24 is associated with a decreased DNA damage response upon etoposide treatment in highly differentiated CD8(+) T cells sensitizing them to apoptotic cell death.JMY functions as actin nucleation-promoting factor and mediator for p53-mediated DNA damage in porcine oocytes.PIASy-dependent SUMOylation regulates DNA topoisomerase IIalpha activity.ERK1/2 signaling plays an important role in topoisomerase II poison-induced G2/M checkpoint activation.Substrate specificity of human protein arginine methyltransferase 7 (PRMT7): the importance of acidic residues in the double E loop.Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotidesBiological Activity of N-Hydroxyethyl-4-aza-2,3-didehydropodophyllotoxin Derivatives upon Colorectal Adenocarcinoma Cells.Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavageRecognition and repair of chemically heterogeneous structures at DNA endsContributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme--drug--DNA complex.Loss of autophagy causes a synthetic lethal deficiency in DNA repair.Etoposide quinone is a redox-dependent topoisomerase II poison
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Etoposide, topoisomerase II and cancer.
@ast
Etoposide, topoisomerase II and cancer.
@en
type
label
Etoposide, topoisomerase II and cancer.
@ast
Etoposide, topoisomerase II and cancer.
@en
prefLabel
Etoposide, topoisomerase II and cancer.
@ast
Etoposide, topoisomerase II and cancer.
@en
P356
P1476
Etoposide, topoisomerase II and cancer.
@en
P2093
Baldwin EL
Osheroff N
P304
P356
10.2174/1568011054222364
P577
2005-07-01T00:00:00Z