The Na(+)/H(+) exchanger: a target for cardiac therapeutic intervention.
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Activated NHE1 is required to induce early cardiac hypertrophy in miceNa(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophyStructural and functional characterization of transmembrane segment IX of the NHE1 isoform of the Na+/H+ exchangerStructural and Functional Analysis of Transmembrane XI of the NHE1 Isoform of the Na+/H+ ExchangerStructural and Functional Analysis of Transmembrane Segment VI of the NHE1 Isoform of the Na+/H+ ExchangerNa+/H+ exchanger isoform 1 facilitates cardiomyocyte embryonic stem cell differentiationSodium-hydrogen exchange inhibition attenuates glycoside-induced hypertrophy in rat ventricular myocytesNovel phorbol ester-binding motif mediates hormonal activation of Na+/H+ exchanger.Cariporide given during resuscitation promotes return of electrically stable and mechanically competent cardiac activity.Gene inactivation of Na+/H+ exchanger isoform 1 attenuates apoptosis and mitochondrial damage following transient focal cerebral ischemiaTargeting mitochondria for resuscitation from cardiac arrest.Elevated myocardial Na+/H+ exchanger isoform 1 activity elicits gene expression that leads to cardiac hypertrophy.Phosphorylation and activation of the plasma membrane Na+/H+ exchanger (NHE1) during osmotic cell shrinkageExcessive Na+/H+ exchange in disruption of dendritic Na+ and Ca2+ homeostasis and mitochondrial dysfunction following in vitro ischemiaLoss of the AE3 anion exchanger in a hypertrophic cardiomyopathy model causes rapid decompensation and heart failure.Protecting mitochondrial bioenergetic function during resuscitation from cardiac arrest.Sabiporide reduces ischemia-induced arrhythmias and myocardial infarction and attenuates ERK phosphorylation and iNOS induction in rats.Structural and functional analysis of the Na+/H+ exchangerPhysiological role and regulation of the Na+/H+ exchanger.The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury.AVE4454B--a novel sodium-hydrogen exchanger isoform-1 inhibitor--compared less effective than cariporide for resuscitation from cardiac arrest.Na+/H+ exchanger 1 inhibition reverses manifestation of peripheral diabetic neuropathy in type 1 diabetic rats.Pathophysiology of Intestinal Na+/H+ exchange.Hijacking solute carriers for proton-coupled drug transport.Effect of taurine on ischemia-reperfusion injury.Mitogen-activated protein kinase-dependent activation of the Na+/H+ exchanger is mediated through phosphorylation of amino acids Ser770 and Ser771.Structural and functional characterization of transmembrane segment VII of the Na+/H+ exchanger isoform 1.Regulation of early neurite morphogenesis by the Na+/H+ exchanger NHE1.B-Raf associates with and activates the NHE1 isoform of the Na+/H+ exchanger.Synthesis of novel ligustrazine derivatives as NA+/H+ exchange inhibitors.The role of Na+-H+ exchanger isoform 1 in aldosterone-induced glomerulosclerosis in vivo.Na+/H+ exchanger 1 gene expression in tissues of yellow chicken.Adverse postresuscitation myocardial effects elicited by buffer-induced alkalemia ameliorated by NHE-1 inhibition in a rat model of ventricular fibrillation.Phenylephrine and sustained acidosis activate the neonatal rat cardiomyocyte Na+/H+ exchanger through phosphorylation of amino acids Ser770 and Ser771.Diastolic calcium is elevated in metabolic recovery of cardiomyocytes expressing elevated levels of the Na+/H+ exchanger.Role of transporters and ion channels in neuronal injury under hypoxia.Dimeric structure of human Na+/H+ exchanger isoform 1 overproduced in Saccharomyces cerevisiae.Elevated expression of activated Na(+)/H(+) exchanger protein induces hypertrophy in isolated rat neonatal ventricular cardiomyocytes.Gender-specific effects of exercise on cardiac pathology in Na(+)/H(+) exchanger overexpressing mice.
P2860
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P2860
The Na(+)/H(+) exchanger: a target for cardiac therapeutic intervention.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
The Na(+)/H(+) exchanger: a target for cardiac therapeutic intervention.
@ast
The Na(+)/H(+) exchanger: a target for cardiac therapeutic intervention.
@en
type
label
The Na(+)/H(+) exchanger: a target for cardiac therapeutic intervention.
@ast
The Na(+)/H(+) exchanger: a target for cardiac therapeutic intervention.
@en
prefLabel
The Na(+)/H(+) exchanger: a target for cardiac therapeutic intervention.
@ast
The Na(+)/H(+) exchanger: a target for cardiac therapeutic intervention.
@en
P2093
P356
P1476
The Na(+)/H(+) exchanger: a target for cardiac therapeutic intervention.
@en
P2093
P304
P356
10.2174/1568006054553417
P577
2005-08-01T00:00:00Z