about
Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancerLoss of STK11 expression is an early event in prostate carcinogenesis and predicts therapeutic response to targeted therapy against MAPK/p38.LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domainA role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndromeA novel mutation in STK11 gene is associated with Peutz-Jeghers Syndrome in Indian patients.Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancerLKB1 destabilizes microtubules in myoblasts and contributes to myoblast differentiationThe LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells.Epidemiology of cancer of the small intestineA single-nucleotide polymorphism in serine-threonine kinase 11, the gene encoding liver kinase B1, is a risk factor for multiple sclerosisAlterations of LKB1 and KRAS and risk of brain metastasis: comprehensive characterization by mutation analysis, copy number, and gene expression in non-small-cell lung carcinoma.Prevalence and specificity of LKB1 genetic alterations in lung cancersLovastatin overcomes gefitinib resistance through TNF-α signaling in human cholangiocarcinomas with different LKB1 statuses in vitro and in vivoCharacterization of the STK11 splicing variant as a normal splicing isomer in a patient with Peutz-Jeghers syndrome harboring genomic deletion of the STK11 geneFrequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer.Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patientsLKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteinsMutational analysis of primary and metastatic colorectal cancer samples underlying the resistance to cetuximab-based therapyA case of synchronous mucinous metaplasia and neoplasia of the female genital tract without an STK11 or KRAS mutation.Novel mutations in the STK11 gene in Thai patients with Peutz-Jeghers syndrome.Prevalence of germline PTEN, BMPR1A, SMAD4, STK11, and ENG mutations in patients with moderate-load colorectal polyps.The LKB1 complex-AMPK pathway: the tree that hides the forestMouse models of lung squamous cell carcinomas.LKB1 when associated with methylatedERα is a marker of bad prognosis in breast cancer.A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinomaLoss of LKB1 and p53 synergizes to alter fallopian tube epithelial phenotype and high-grade serous tumorigenesis.Somatic alterations of the serine/threonine kinase LKB1 gene in squamous cell (SCC) and large cell (LCC) lung carcinoma.Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications.Duodenal cancer in a young patient with Peuts-Jeghers syndrome harboring an entire deletion of the STK11 gene.Novel mutations and role of the LKB1 gene as a tumor suppressor in renal cell carcinoma.High expression of partitioning defective 3-like protein is associated with malignancy in colorectal cancer.LKB1 loss at transcriptional level promotes tumor malignancy and poor patient outcomes in colorectal cancer.Exome sequencing revealed novel germline mutations in Chinese Peutz-Jeghers syndrome patients.LKB1 gene alterations in surgically resectable adenocarcinoma of the lung.
P2860
Q26769935-4D983810-E130-4E8B-BDB6-13C05DEE283AQ27853215-F9897CF9-D3A2-4097-9A96-24633031B8D5Q28280001-38436265-5509-4BA4-B103-D6830FBD0528Q28307804-8E9AF85F-582B-4267-86B8-91EF2707839DQ33258856-A2C86313-7B08-4426-A428-B886C08F9E63Q33554443-02E6AF7B-44EC-4B0B-B50F-B4B8F306B2D3Q34163651-30862BBB-D625-4F98-B6EB-9919EB639B1FQ34345692-37ED2FBF-D98D-4B8D-98AA-B1E9CA633202Q34628138-C4A956FC-AE75-4CA8-A866-09B0E5C688F4Q35126302-ADAA04FB-2358-4496-9CA4-531C96046CD4Q35185119-F886BEF3-8520-41D6-BA4A-7DA6EC0DB08CQ36277692-CA6F049D-1870-4042-BF6C-845F3821295FQ36414323-199E1401-216E-4ECE-838A-36C79041FEA8Q36644008-350E4FB4-05C5-4EFD-8DDD-89FFE4583914Q36740152-3E58557E-29D6-4D41-8543-B92356ED86C4Q36785938-BDB12F1B-9347-4002-9A6F-DE7D556723ABQ36999520-1D7332F2-D87A-4B13-927F-559FFD0FFABFQ37142999-19B1E601-B5CD-40F5-AED0-AF41DABA59A8Q37390352-6D372705-5BF3-400A-AE5C-E070955E8334Q37420057-38608867-6AC8-459C-AB8C-F5D8D7F0E822Q37671215-3386EF0B-1ACE-4C8C-BFE1-81996A0649F7Q37886809-D9E8737E-8D0E-4FF7-9F40-E46325A23739Q38066417-0130C4B8-E128-42B1-9616-3BC06406D4BDQ39016686-B1FBC01B-4184-4350-A050-78AE07910471Q40330894-DFBCBBAB-9293-4EF1-A34D-FF4F0FDDD912Q41179162-620296FA-E4C9-4A38-9F17-2253825D066FQ46116199-6B90AFDA-3DD8-4452-A3EE-8B1D177C9CE1Q47323319-303A94DF-803F-4A71-B729-E164C946AA53Q47773920-89A3507F-CB4C-4182-95B9-1FD603BBC258Q48569709-9C13DE4B-0ED0-4B33-8A5F-A23A1118D73FQ50700668-192BE856-E44D-42F7-A67C-CBD5380F4AC0Q54348800-06AE8E16-58A0-4E60-A99E-173282E8D276Q54401186-F8989523-A037-4F81-AB2A-087455520A00Q54623826-9813DD58-01F2-484B-A0E0-91D7FCE6C262
P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Mutations in the human LKB1/STK11 gene.
@ast
Mutations in the human LKB1/STK11 gene.
@en
type
label
Mutations in the human LKB1/STK11 gene.
@ast
Mutations in the human LKB1/STK11 gene.
@en
prefLabel
Mutations in the human LKB1/STK11 gene.
@ast
Mutations in the human LKB1/STK11 gene.
@en
P2860
P356
P1433
P1476
Mutations in the human LKB1/STK11 gene.
@en
P2093
Virpi Launonen
P2860
P304
P356
10.1002/HUMU.20222
P577
2005-10-01T00:00:00Z