Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis
about
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascadeMO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasmActivation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRADHeat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stabilityTargeting LKB1 in cancer - exposing and exploiting vulnerabilitiesCrystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptorStem cell dynamics and pretumor progression in the intestinal tractIonizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366LKB1 as the ghostwriter of crypt historyThe LKB1-AMPK pathway: metabolism and growth control in tumour suppressionOpinion: alternative views of AMP-activated protein kinase.Mouse models of human familial cancer syndromes.STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and miceLower gastrointestinal tract cancer predisposition syndromesChemopreventive efficacy of rapamycin on Peutz-Jeghers syndrome in a mouse model.Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in miceMouse models of inherited cancer syndromesInteraction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interactionLKB1 (XEEK1) regulates Wnt signalling in vertebrate development.De novo germline mutation in the serine-threonine kinase STK11/LKB1 gene associated with Peutz-Jeghers syndrome.LKB1, the multitasking tumour suppressor kinaseFunctional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructoseIdentification of patients at risk for hereditary colorectal cancerLkb1 regulates cell cycle and energy metabolism in haematopoietic stem cellsLKB1 preserves genome integrity by stimulating BRCA1 expression.Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancersDisabled-2 heterozygous mice are predisposed to endometrial and ovarian tumorigenesis and exhibit sex-biased embryonic lethality in a p53-null backgroundAMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma.Mutations in the human LKB1/STK11 gene.Intact LKB1 activity is required for survival of dormant ovarian cancer spheroidsLkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways.Novel genetically-humanized mouse model established to evaluate efficacy of therapeutic agents to human interleukin-6 receptor.Phosphorylation of serine 399 in LKB1 protein short form by protein kinase Cζ is required for its nucleocytoplasmic transport and consequent AMP-activated protein kinase (AMPK) activationLKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest.LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye.Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis.mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome.LKB1; linking cell structure and tumor suppression.
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P2860
Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Role of Lkb1, the causative ge ...... in embryogenesis and polyposis
@ast
Role of Lkb1, the causative ge ...... in embryogenesis and polyposis
@en
Role of Lkb1, the causative ge ...... in embryogenesis and polyposis
@nl
type
label
Role of Lkb1, the causative ge ...... in embryogenesis and polyposis
@ast
Role of Lkb1, the causative ge ...... in embryogenesis and polyposis
@en
Role of Lkb1, the causative ge ...... in embryogenesis and polyposis
@nl
prefLabel
Role of Lkb1, the causative ge ...... in embryogenesis and polyposis
@ast
Role of Lkb1, the causative ge ...... in embryogenesis and polyposis
@en
Role of Lkb1, the causative ge ...... in embryogenesis and polyposis
@nl
P2093
P2860
P356
P1476
Role of Lkb1, the causative ge ...... in embryogenesis and polyposis
@en
P2093
Akio Miyoshi
Dieter E Jenne
Hiroshi Suzuki
Jun-ichi Nezu
Kiyoshi Habu
Kou-ichi Jishage
Michiko Kinoshita
Miho Watanabe
Miyuki Shimane
P2860
P304
P356
10.1073/PNAS.122254599
P407
P577
2002-06-11T00:00:00Z