Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis - Wikidata - wikimedia - TriplyDB

Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis

Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis

http://www.wikidata.org/entity/Q34066238

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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability Targeting LKB1 in cancer - exposing and exploiting vulnerabilities Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor Stem cell dynamics and pretumor progression in the intestinal tract Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366 LKB1 as the ghostwriter of crypt history The LKB1-AMPK pathway: metabolism and growth control in tumour suppression Opinion: alternative views of AMP-activated protein kinase.Mouse models of human familial cancer syndromes.STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice Lower gastrointestinal tract cancer predisposition syndromes Chemopreventive efficacy of rapamycin on Peutz-Jeghers syndrome in a mouse model.Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice Mouse models of inherited cancer syndromes Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction LKB1 (XEEK1) regulates Wnt signalling in vertebrate development.De novo germline mutation in the serine-threonine kinase STK11/LKB1 gene associated with Peutz-Jeghers syndrome.LKB1, the multitasking tumour suppressor kinase Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose Identification of patients at risk for hereditary colorectal cancer Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells LKB1 preserves genome integrity by stimulating BRCA1 expression.Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancers Disabled-2 heterozygous mice are predisposed to endometrial and ovarian tumorigenesis and exhibit sex-biased embryonic lethality in a p53-null background AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma.Mutations in the human LKB1/STK11 gene.Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways.Novel genetically-humanized mouse model established to evaluate efficacy of therapeutic agents to human interleukin-6 receptor.Phosphorylation of serine 399 in LKB1 protein short form by protein kinase Cζ is required for its nucleocytoplasmic transport and consequent AMP-activated protein kinase (AMPK) activation LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest.LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye.Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis.mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome.LKB1; linking cell structure and tumor suppression.

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Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis

http://www.wikidata.org/entity/Q34066238

description

2002 nî lūn-bûn

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2002 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2002 թվականի հունիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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Role of Lkb1, the causative ge ...... in embryogenesis and polyposis

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Role of Lkb1, the causative ge ...... in embryogenesis and polyposis

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Role of Lkb1, the causative ge ...... in embryogenesis and polyposis

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Role of Lkb1, the causative ge ...... in embryogenesis and polyposis

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Role of Lkb1, the causative ge ...... in embryogenesis and polyposis

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Role of Lkb1, the causative ge ...... in embryogenesis and polyposis

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Role of Lkb1, the causative ge ...... in embryogenesis and polyposis

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Role of Lkb1, the causative ge ...... in embryogenesis and polyposis

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Role of Lkb1, the causative ge ...... in embryogenesis and polyposis

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Proceedings of the National Academy of Sciences of the United States of America

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Role of Lkb1, the causative ge ...... in embryogenesis and polyposis

@en

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Akio Miyoshi

http://www.w3.org/2001/XMLSchema#string

Asuka Ose

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Dieter E Jenne

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Hiroshi Suzuki

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Jun-ichi Nezu

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Kiyoshi Habu

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Kou-ichi Jishage

http://www.w3.org/2001/XMLSchema#string

Michiko Kinoshita

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Miho Watanabe

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Miyuki Shimane

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P2860

The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis

Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice

Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3.

Haplo-insufficiency? Let me count the ways.

Peutz-Jeghers syndrome: its natural course and management.

Peutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma

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8903-8908

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scholarly article

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10.1073/PNAS.122254599

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13

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99

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2002-06-11T00:00:00Z

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11313100

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12060709

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124396

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