Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions.
about
The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif proteinPhosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinasesCoordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeletonSelective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphataseIdentification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1Src kinase activation by direct interaction with the integrin beta cytoplasmic domainSrc kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophilsFgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophilsPRAM-1 is required for optimal integrin-dependent neutrophil functionCompartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesionGranulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent mannerImpaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils.Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinaseBiochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with HckProtein-tyrosine phosphatase alpha regulates Src family kinases and alters cell-substratum adhesionEnhanced neutrophil response in chronic obstructive pulmonary diseaseIntegrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifsBcr and Abr cooperate in negatively regulating acute inflammatory responsesNeutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infectionThe Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanineNeutrophil cell surface receptors and their intracellular signal transduction pathways.The HIV Nef protein alters Ca(2+) signaling in myelomonocytic cells through SH3-mediated protein-protein interactions.Overexpression of C-terminal Src kinase homologous kinase suppresses activation of Lyn tyrosine kinase required for VLA5-mediated Dami cell spreading.PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling.The role of endothelial PI3Kgamma activity in neutrophil trafficking.Junctional adhesion molecule-A-deficient polymorphonuclear cells show reduced diapedesis in peritonitis and heart ischemia-reperfusion injury.Neutrophils lacking phosphoinositide 3-kinase gamma show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxisRho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophilsProteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin.A role for leukocyte-endothelial adhesion mechanisms in epilepsyThe small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signalingMigrational guidance of neutrophils is mechanotransduced via high-affinity LFA-1 and calcium fluxCdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubulesPlatelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase.A protective role for ELR+ chemokines during acute viral encephalomyelitis.Orai1 regulates intracellular calcium, arrest, and shape polarization during neutrophil recruitment in shear flow.The molecular basis for adhesion-mediated suppression of reactive oxygen species generation by human neutrophilsA functional granulocyte colony-stimulating factor receptor is required for normal chemoattractant-induced neutrophil activation.Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF.C-Src and c-Yes are two unlikely partners of spermatogenesis and their roles in blood-testis barrier dynamics.
P2860
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P2860
Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Deficiency of Src family kinas ...... ependent neutrophil functions.
@ast
Deficiency of Src family kinas ...... ependent neutrophil functions.
@en
type
label
Deficiency of Src family kinas ...... ependent neutrophil functions.
@ast
Deficiency of Src family kinas ...... ependent neutrophil functions.
@en
prefLabel
Deficiency of Src family kinas ...... ependent neutrophil functions.
@ast
Deficiency of Src family kinas ...... ependent neutrophil functions.
@en
P2093
P2860
P356
P1476
Deficiency of Src family kinas ...... ependent neutrophil functions.
@en
P2093
P2860
P304
P356
10.1083/JCB.133.4.895
P407
P577
1996-05-01T00:00:00Z