Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells.
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Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexesInvolvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrestProtein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cellsp14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activityThe HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase IIThe roles of cyclin A2, B1, and B2 in early and late mitotic eventsA human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damageNuclear localization of cyclin B1 controls mitotic entry after DNA damageExpression of constitutively active CDK1 stabilizes APC-Cdh1 substrates and potentiates premature spindle assembly and checkpoint function in G1 cellsThe SFP1 gene product of Saccharomyces cerevisiae regulates G2/M transitions during the mitotic cell cycle and DNA-damage responseCell cycle control in the early embryonic development of aquatic animal speciesSCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphataseWee1 inhibition by MK-1775 leads to tumor inhibition and enhances efficacy of gemcitabine in human sarcomasFine tuning the cell cycle: activation of the Cdk1 inhibitory phosphorylation pathway during mitotic exit.Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF.Grapes(Chk1) prevents nuclear CDK1 activation by delaying cyclin B nuclear accumulation.Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibitedChk1 and Wee1 kinases coordinate DNA replication, chromosome condensation, and anaphase entry.The Haemophilus ducreyi cytolethal distending toxin induces cell cycle arrest and apoptosis via the DNA damage checkpoint pathways.Entry into mitosis in vertebrate somatic cells is guarded by a chromosome damage checkpoint that reverses the cell cycle when triggered during early but not late prophase.Cooperative effect of p21Cip1/WAF-1 and 14-3-3sigma on cell cycle arrest and apoptosis induction by p14ARF.Cell cycle control, checkpoint mechanisms, and genotoxic stress.Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation.S and G2 phase roles for Cdk2 revealed by inducible expression of a dominant-negative mutant in human cells.Cdc25-dependent activation of cyclin A/cdk2 is blocked in G2 phase arrested cells independently of ATM/ATR.DNA replication and damage checkpoints and meiotic cell cycle controls in the fission and budding yeasts.Roles of the mitotic inhibitors Wee1 and Mik1 in the G(2) DNA damage and replication checkpoints.Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae.Cell cycle checkpoints and their inactivation in human cancer.Mechanisms of cell-cycle checkpoints: at the crossroads of carcinogenesis and drug discovery.Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints.The Schizosaccharomyces pombe S-phase checkpoint differentiates between different types of DNA damageHistone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells.Thymoquinone-loaded nanostructured lipid carrier exhibited cytotoxicity towards breast cancer cell lines (MDA-MB-231 and MCF-7) and cervical cancer cell lines (HeLa and SiHa)Cannabinoid receptor activation inhibits cell cycle progression by modulating 14-3-3β.DNA damage checkpoint control in cells exposed to ionizing radiation.Ndd1 turnover by SCF(Grr1) is inhibited by the DNA damage checkpoint in Saccharomyces cerevisiae.Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcementThree Different Pathways Prevent Chromosome Segregation in the Presence of DNA Damage or Replication Stress in Budding YeastMK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts
P2860
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P2860
Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells.
@ast
Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells.
@en
type
label
Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells.
@ast
Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells.
@en
prefLabel
Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells.
@ast
Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells.
@en
P2093
P2860
P356
P1476
Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells.
@en
P2093
P2860
P304
P356
10.1083/JCB.134.4.963
P407
P577
1996-08-01T00:00:00Z