Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.
about
Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentrationSkeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3AMPK: a cellular metabolic and redox sensor. A minireviewMolecular basis of physiological heart growth: fundamental concepts and new playersEvidence of cancer-promoting roles for AMPK and related kinasesActivation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytesExpression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophyInvestigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activityAMPK: a nutrient and energy sensor that maintains energy homeostasisAMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosisEffect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: a time-course and dose-response studyRegulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes.Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function.Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity.Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium.Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cellsRegulation of AMPK by the ubiquitin proteasome systemAMPK in cardiovascular health and disease.C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart.Ablation of SGK1 impairs endothelial cell migration and tube formation leading to decreased neo-angiogenesis following myocardial infarctionSubcellular trafficking of the substrate transporters GLUT4 and CD36 in cardiomyocytesHypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activationAMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise.Defective myofibroblast formation from mesenchymal stem cells in the aging murine heart rescue by activation of the AMPK pathway.A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway.LKB1 and Notch Pathways Interact and Control Biliary Morphogenesis.Cellular responses to the metal-binding properties of metformin.AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism.Lysophosphatidic acid activates lipogenic pathways and de novo lipid synthesis in ovarian cancer cells.AMP-activated protein kinase mediates preconditioning in cardiomyocytes by regulating activity and trafficking of sarcolemmal ATP-sensitive K(+) channels.AMP-activated protein kinase--development of the energy sensor concept.AMPK alterations in cardiac physiology and pathology: enemy or ally?AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues.AMP-activated protein kinase and the regulation of Ca2+ signalling in O2-sensing cells.Role of AMP-activated protein kinase in healthy and diseased hearts.AMP-activated protein kinase contributes to zinc-induced neuronal death via activation by LKB1 and induction of Bim in mouse cortical cultures.Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge.Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells
P2860
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P2860
Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Deficiency of LKB1 in heart pr ...... AMPKalpha2 but not AMPKalpha1.
@ast
Deficiency of LKB1 in heart pr ...... AMPKalpha2 but not AMPKalpha1.
@en
type
label
Deficiency of LKB1 in heart pr ...... AMPKalpha2 but not AMPKalpha1.
@ast
Deficiency of LKB1 in heart pr ...... AMPKalpha2 but not AMPKalpha1.
@en
prefLabel
Deficiency of LKB1 in heart pr ...... AMPKalpha2 but not AMPKalpha1.
@ast
Deficiency of LKB1 in heart pr ...... AMPKalpha2 but not AMPKalpha1.
@en
P2093
P2860
P50
P1476
Deficiency of LKB1 in heart pr ...... AMPKalpha2 but not AMPKalpha1.
@en
P2093
Aleksandar Jovanović
Anindya Dutta
Anne-Catherine Pouleur
Elham Zarrinpashneh
Grant R Budas
Kei Sakamoto
Luc Bertrand
P2860
P304
P356
10.1152/AJPENDO.00443.2005
P577
2005-12-06T00:00:00Z