Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1. - Wikidata - wikimedia - TriplyDB

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.

http://www.wikidata.org/entity/Q36248613

about

Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3 AMPK: a cellular metabolic and redox sensor. A minireview Molecular basis of physiological heart growth: fundamental concepts and new players Evidence of cancer-promoting roles for AMPK and related kinases Activation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytes Expression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophy Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity AMPK: a nutrient and energy sensor that maintains energy homeostasis AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: a time-course and dose-response study Regulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes.Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function.Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity.Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium.Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells Regulation of AMPK by the ubiquitin proteasome system AMPK in cardiovascular health and disease.C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart.Ablation of SGK1 impairs endothelial cell migration and tube formation leading to decreased neo-angiogenesis following myocardial infarction Subcellular trafficking of the substrate transporters GLUT4 and CD36 in cardiomyocytes Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation AMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise.Defective myofibroblast formation from mesenchymal stem cells in the aging murine heart rescue by activation of the AMPK pathway.A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway.LKB1 and Notch Pathways Interact and Control Biliary Morphogenesis.Cellular responses to the metal-binding properties of metformin.AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism.Lysophosphatidic acid activates lipogenic pathways and de novo lipid synthesis in ovarian cancer cells.AMP-activated protein kinase mediates preconditioning in cardiomyocytes by regulating activity and trafficking of sarcolemmal ATP-sensitive K(+) channels.AMP-activated protein kinase--development of the energy sensor concept.AMPK alterations in cardiac physiology and pathology: enemy or ally?AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues.AMP-activated protein kinase and the regulation of Ca2+ signalling in O2-sensing cells.Role of AMP-activated protein kinase in healthy and diseased hearts.AMP-activated protein kinase contributes to zinc-induced neuronal death via activation by LKB1 and induction of Bim in mouse cortical cultures.Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge.Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells

P2860

Q22241965-0DE724F4-6AB4-4977-8AA8-38B4C703762C Q24672153-723C60EC-BE56-4ED2-B748-A55D88889FE9 Q26995682-B86BB263-19F6-4556-8D72-5324C3933DF7 Q27006868-D03C5657-0EA7-4D6F-AF70-16BB1E2ED507 Q28083964-DFE08204-C632-4517-A1CB-FED5E0AFD3DE Q28580371-E4DB5CC2-92EA-4C31-B2ED-D04C8BAF2E7B Q28580464-869CFFA2-0858-44F0-9698-412CDAB6FCFE Q28591614-99CBBD80-6F2D-4EED-831C-E7DE4A9B9000 Q29615410-70196CE1-B04C-4593-8287-FA15A1D4893F Q30481019-8E60D886-221C-4464-9555-2309E9248351 Q33747784-916E3122-E7ED-46AD-A091-D07210BA9231 Q33818339-B7A89BCD-1FFF-4414-86F3-DA6B1B192A77 Q33945472-2AB3BD8D-4790-46FF-89D8-483A9A6918EF Q33968008-232556B3-E50F-4B06-A08B-9726187E2B9A Q34333517-0E0CB3CC-BC50-4484-A3F4-54CE935578AF Q34505650-177B8AB6-A1AB-4796-A8A3-ED5B845E9345 Q34690043-C303860F-13FC-4A6E-A1AE-F4D7F3C27487 Q34756301-8B63D7AD-65A8-4A69-B211-FE298A5BB4CA Q34807222-352948C7-AE3C-4FBA-8AE0-FEBB3214FB8D Q34852643-3E97F24A-28E0-4E0F-94F0-8F606378B9F9 Q35039324-F09A9C27-5937-4609-ACC1-C3B36C66C8B9 Q35050584-A3C4C15F-CD5D-469B-A41B-6FBBD3AE6D3E Q35100504-C6FF4963-45C3-4D8B-BA5D-8895CB4651B4 Q35192115-969908BB-2443-4F40-9BBF-DDCF8A9A9BA8 Q35229081-4F6F5C2C-CFCB-4AB2-B224-D454341982A0 Q35235783-36BAFEC0-5817-4716-9FCD-3B54914D0147 Q35768634-04A09983-097B-4750-B384-14871617E7E7 Q35874238-7FAB171E-7C2E-478F-9852-C3298A71A510 Q35976604-C7DF3243-8294-4783-9255-A3E43A42ECB0 Q36048973-DC66C7B7-A16C-46F7-B50F-EFDA1CD923F7 Q36127217-CF0CCA15-0E24-475B-B3CD-0155FD3137E4 Q36247802-940A7AAD-0FD8-44B3-92A5-E3087344597A Q36462587-4A8CCBB0-256D-4816-8508-43D4240743DF Q36475855-F164F337-397F-41D2-B0BA-EC9978F83766 Q36482341-698AECE8-C43A-438C-A0F6-98ABC1F7E3F1 Q36482354-BF6931A8-7CFF-4877-ADC3-34A2BF5BC81F Q36537821-12CBEB12-AC81-4C54-B505-78D0A52808F7 Q36560589-93DA3453-D8A0-4A52-B2FA-4DD58907A197 Q36877540-BFC89D0F-4E7A-46CD-AA50-48ADA82F1605 Q36927955-62FDFA63-B441-41A7-BE4F-C3404F10A4DD

P2860

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.

http://www.wikidata.org/entity/Q36248613

description

2005 nî lūn-bûn

@nan

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

2005年论文

@zh

2005年论文

@zh-cn

name

Deficiency of LKB1 in heart pr ...... AMPKalpha2 but not AMPKalpha1.

@ast

Deficiency of LKB1 in heart pr ...... AMPKalpha2 but not AMPKalpha1.

@en

type

label

Deficiency of LKB1 in heart pr ...... AMPKalpha2 but not AMPKalpha1.

@ast

Deficiency of LKB1 in heart pr ...... AMPKalpha2 but not AMPKalpha1.

@en

prefLabel

Deficiency of LKB1 in heart pr ...... AMPKalpha2 but not AMPKalpha1.

@ast

Deficiency of LKB1 in heart pr ...... AMPKalpha2 but not AMPKalpha1.

@en

P1433

Q36248613-8DAFCEB8-EB9B-49BD-872B-B8DF18CC822C

P1476

Q36248613-F6C6E45E-B5E5-426D-A2BD-37029EBD7F8E

P2093

Q36248613-0BBC8092-D907-4F75-AAD6-C4BB5C7F4CA3

Q36248613-375EAB81-5799-4216-B29C-DA2A5EC78443

Q36248613-87364AD5-9446-4314-A262-D8B38D20AD0C

Q36248613-A955A7F7-EA28-4BBE-9281-150324C27D9C

Q36248613-B10FB785-C98C-4FDE-A71C-25223535F3C5

Q36248613-D734FE9F-CEB3-44B9-AE1B-26570631541F

Q36248613-FD451DE4-53D4-47F9-B233-2573C236B0D0

P2860

Q36248613-0253275E-C8B4-4742-899D-378805D2B034

Q36248613-18E04E27-55E7-4133-82E1-01D33BD2D2D0

Q36248613-1BDC8F98-7861-40E5-91E3-4410C4F43833

Q36248613-25DDB065-DC3A-42FA-B4FE-843A1B23AA9A

Q36248613-3455AF6A-F44F-4EFC-9639-78FC83B4944E

Q36248613-3DB5A614-6417-4683-9CE9-491C87B778EA

Q36248613-42622162-E462-4EE9-9943-5D376245949B

Q36248613-4ABCD0F1-AA70-4E9F-B5B9-32EB95E32DF9

Q36248613-4CD75EDD-E4E3-424B-9D13-D044368D7DC7

Q36248613-4FEBFB1E-6D3C-47D1-B4C8-641621134370

P304

Q36248613-EEA0E521-FCC4-4B07-AE65-4F8BCD4704EF

P31

Q36248613-ADD02346-BDCE-4AFA-A62C-0E2F6130BCE6

P356

Q36248613-DA0E735B-587E-49B2-AEAA-8CF31CC96EAB

P433

Q36248613-40A00065-8103-4848-BD8A-1E131FE32860

P478

Q36248613-17FE120D-797B-4C24-B219-6734EF2188D4

P50

Q36248613-037D38B9-086F-46F5-9FAA-900A9412B806

Q36248613-231F7647-0322-4502-8C41-9A5A09A1E194

Q36248613-51A816AA-500B-4906-916D-A05E39875C81

Q36248613-E45B1A8F-3AD5-4753-A5D3-42570C871127

P577

Q36248613-60C75E71-4DFA-4F29-A0E3-A4E4DCEAD2C8

P5875

Q36248613-792A33E3-ADD9-44BC-8C66-E1A17B88027A

P698

Q36248613-D9E95CAE-68B6-4501-B6AC-67EA8AA86BD9

P932

Q36248613-9D6F2356-638D-40A4-8EE8-2FB75B4DE6FA

P356

AJPENDO.00443.2005

P1433

American Journal of Physiology - Endocrinology and Metabolism

P1476

Deficiency of LKB1 in heart pr ...... AMPKalpha2 but not AMPKalpha1.

@en

P2093

Aleksandar Jovanović

http://www.w3.org/2001/XMLSchema#string

Anindya Dutta

http://www.w3.org/2001/XMLSchema#string

Anne-Catherine Pouleur

http://www.w3.org/2001/XMLSchema#string

Elham Zarrinpashneh

http://www.w3.org/2001/XMLSchema#string

Grant R Budas

http://www.w3.org/2001/XMLSchema#string

Kei Sakamoto

http://www.w3.org/2001/XMLSchema#string

Luc Bertrand

http://www.w3.org/2001/XMLSchema#string

P2860

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

The subcellular localization of acetyl-CoA carboxylase 2

Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Yeast Pak1 kinase associates with and activates Snf1

Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases.

The AMP-activated protein kinase cascade--a unifying system for energy control

Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta

Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

P304

E780-8

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1152/AJPENDO.00443.2005

http://www.w3.org/2001/XMLSchema#string

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

290

http://www.w3.org/2001/XMLSchema#string

P50

Alan R. Prescott

Jean-Louis Vanoverschelde

P577

2005-12-06T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

7436552

http://www.w3.org/2001/XMLSchema#string

P698

16332922

http://www.w3.org/2001/XMLSchema#string

P932

2128705

http://www.w3.org/2001/XMLSchema#string