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PCSK9 inhibition in the management of hyperlipidemia: focus on evolocumabEngineering therapeutic antibodies targeting G-protein-coupled receptorsRecent Progress towards Novel EV71 Anti-Therapeutics and VaccinesHIV-1 neutralizing antibodies: understanding nature's pathwaysProduction of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1Practical considerations for nonclinical safety evaluation of therapeutic monoclonal antibodiesGolimumab for the treatment of ulcerative colitisThe construction of transgenic and gene knockout/knockin mouse models of human diseaseMonoclonal antibody therapies against anthraxHigh-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH regionCharacterization of the rabbit neonatal Fc receptor (FcRn) and analyzing the immunophenotype of the transgenic rabbits that overexpresses FcRnAntigen-specific monoclonal antibodies isolated from B cells expressing constitutively active STAT5A humanized anti-VEGF rabbit monoclonal antibody inhibits angiogenesis and blocks tumor growth in xenograft modelsEmerging antigenic variants at the antigenic site Sb in pandemic A(H1N1)2009 influenza virus in Japan detected by a human monoclonal antibody.Human monoclonal antibodies broadly neutralizing against influenza B virus.Synthetic antibodies as therapeutics.Design of synthetic antibody libraries.Isolation of human monoclonal antibodies by mammalian cell display.New engineered antibodies against prions.Mining human antibody repertoires.The smart targeting of nanoparticlesMolecular imaging of rheumatoid arthritis by radiolabelled monoclonal antibodies: new imaging strategies to guide molecular therapiesA recombinant humanized anti-cocaine monoclonal antibody inhibits the distribution of cocaine to the brain in ratsCoupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodiesEngineering venom's toxin-neutralizing antibody fragments and its therapeutic potential.The immunogenicity of humanized and fully human antibodies: residual immunogenicity resides in the CDR regionsDiscovery and mechanism of ustekinumab: a human monoclonal antibody targeting interleukin-12 and interleukin-23 for treatment of immune-mediated disorders.Development of anti-infectives using phage display: biological agents against bacteria, viruses, and parasites.An efficient method for variable region assembly in the construction of scFv phage display libraries using independent strand amplification.High affinity humanized antibodies without making hybridomas; immunization paired with mammalian cell display and in vitro somatic hypermutationIdentification of human monoclonal antibodies specific for human SOD1 recognizing distinct epitopes and forms of SOD1.Transgenic rabbits that overexpress the neonatal Fc receptor (FcRn) generate higher quantities and improved qualities of anti-thymocyte globulin (ATG).Development of scoring functions for antibody sequence assessment and optimization.Generation of “LYmph Node Derived Antibody Libraries” (LYNDAL) for selecting fully human antibody fragments with therapeutic potentialHarnessing gene conversion in chicken B cells to create a human antibody sequence repertoire.Prophylaxis and therapy of inhalational anthrax by a novel monoclonal antibody to protective antigen that mimics vaccine-induced immunity.Species-Specific Chromosome Engineering Greatly Improves Fully Human Polyclonal Antibody Production Profile in Cattle.Characterization of a recombinant humanized anti-cocaine monoclonal antibody and its Fab fragment.Clinical development of anti-RANKL therapyTargeting membrane proteins for antibody discovery using phage display.
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Human antibodies from transgenic animals.
@ast
Human antibodies from transgenic animals.
@en
type
label
Human antibodies from transgenic animals.
@ast
Human antibodies from transgenic animals.
@en
prefLabel
Human antibodies from transgenic animals.
@ast
Human antibodies from transgenic animals.
@en
P2860
P356
P1433
P1476
Human antibodies from transgenic animals.
@en
P2093
Nils Lonberg
P2860
P2888
P304
P356
10.1038/NBT1135
P577
2005-09-01T00:00:00Z
P5875
P6179
1050233414