Subtle neuromuscular defects in utrophin-deficient mice.
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Rapsyn mutations in humans cause endplate acetylcholine-receptor deficiency and myasthenic syndromeAbsence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophinFrom pluripotency to myogenesis: a multistep process in the dishInteractions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinasesDifferential targeting of components of the dystrophin complex to the postsynaptic membraneDNA methylation changes in the placenta are associated with fetal manganese exposureInhibition of synapse assembly in mammalian muscle in vivo by RNA interferenceDifferential targeting of components of the dystrophin complex to the postsynaptic membraneDystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype.Blastocyst injection of wild type embryonic stem cells induces global corrections in mdx mice.Formation of the neuromuscular junction. Agrin and its unusual receptors.Excitation-contraction coupling alterations in mdx and utrophin/dystrophin double knockout mice: a comparative study.Dystrophin and utrophin: genetic analyses of their role in skeletal muscle.Role of exercise in maintaining the integrity of the neuromuscular junction.Why so many forms of acetylcholinesterase?Regulation and functional significance of utrophin expression at the mammalian neuromuscular synapse.Dystrophins, utrophins, and associated scaffolding complexes: role in mammalian brain and implications for therapeutic strategies.The alpha-syntrophin PH and PDZ domains scaffold acetylcholine receptors, utrophin, and neuronal nitric oxide synthase at the neuromuscular junction.Expression of mutant Ets protein at the neuromuscular synapse causes alterations in morphology and gene expressionSarcospan-dependent Akt activation is required for utrophin expression and muscle regeneration.Disruption of basal lamina components in neuromotor synapses of children with spastic quadriplegic cerebral palsyVBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects.Transgenic expression of {alpha}7{beta}1 integrin maintains muscle integrity, increases regenerative capacity, promotes hypertrophy, and reduces cardiomyopathy in dystrophic mice.Expression of the dystrophin isoform Dp116 preserves functional muscle mass and extends lifespan without preventing dystrophy in severely dystrophic miceNeuregulin/ErbB regulate neuromuscular junction development by phosphorylation of α-dystrobrevinEndpoint measures in the mdx mouse relevant for muscular dystrophy pre-clinical studies.Nonmechanical Roles of Dystrophin and Associated Proteins in Exercise, Neuromuscular Junctions, and Brains.Postsynaptic abnormalities at the neuromuscular junctions of utrophin-deficient miceMembrane targeting and stabilization of sarcospan is mediated by the sarcoglycan subcomplex.Differential membrane localization and intermolecular associations of alpha-dystrobrevin isoforms in skeletal muscleDistinct regions in the 3' untranslated region are responsible for targeting and stabilizing utrophin transcripts in skeletal muscle cells.Role of extracellular matrix proteins and their receptors in the development of the vertebrate neuromuscular junctionAlpha1-syntrophin-deficient skeletal muscle exhibits hypertrophy and aberrant formation of neuromuscular junctions during regeneration.Tyrosine-phosphorylated and nonphosphorylated isoforms of alpha-dystrobrevin: roles in skeletal muscle and its neuromuscular and myotendinous junctions.Enhanced expression of the alpha 7 beta 1 integrin reduces muscular dystrophy and restores viability in dystrophic miceDystrophin and utrophin isoforms are expressed in glia, but not neurons, of the avian parasympathetic ciliary ganglionC-terminal-truncated microdystrophin recruits dystrobrevin and syntrophin to the dystrophin-associated glycoprotein complex and reduces muscular dystrophy in symptomatic utrophin/dystrophin double-knockout miceMolecular and cellular adaptations to chronic myotendinous strain injury in mdx mice expressing a truncated dystrophin.The synaptic CT carbohydrate modulates binding and expression of extracellular matrix proteins in skeletal muscle: Partial dependence on utrophin.Myotendinous junction defects and reduced force transmission in mice that lack alpha7 integrin and utrophin
P2860
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P2860
Subtle neuromuscular defects in utrophin-deficient mice.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Subtle neuromuscular defects in utrophin-deficient mice.
@ast
Subtle neuromuscular defects in utrophin-deficient mice.
@en
type
label
Subtle neuromuscular defects in utrophin-deficient mice.
@ast
Subtle neuromuscular defects in utrophin-deficient mice.
@en
prefLabel
Subtle neuromuscular defects in utrophin-deficient mice.
@ast
Subtle neuromuscular defects in utrophin-deficient mice.
@en
P2093
P2860
P356
P1476
Subtle neuromuscular defects in utrophin-deficient mice.
@en
P2093
P2860
P304
P356
10.1083/JCB.136.4.871
P407
P577
1997-02-01T00:00:00Z