Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor
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Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivoPks, a raf-related sequence in humansAngiotensin II stimulates ERK via two pathways in epithelial cells: protein kinase C suppresses a G-protein coupled receptor-EGF receptor transactivation pathway.Protein phosphorylation in a tetradecanoyl phorbol acetate-nonproliferative variant of 3T3 cells.Signal transduction by the epidermal growth factor receptor after functional desensitization of the receptor tyrosine protein kinase activity.Phosphorylation at threonine-654 is not required for negative regulation of the epidermal growth factor receptor by non-phorbol tumor promoters.The role of EGF receptor transmodulation in embryonal carcinoma-derived growth factor-induced mitogenesisActivation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation.Antagonistic effects of protein kinase C alpha and delta on both transformation and phospholipase D activity mediated by the epidermal growth factor receptor.Human epidermal growth factor receptor (HER1) aligned on the plasma membrane adopts key features of Drosophila EGFR asymmetry.Investigating extracellular in situ EGFR structure and conformational changes using FRET microscopy.Stimulation of phosphorylation of lipocortin at threonine residues by epidermal growth factor (EGF) and the EGF receptor: addition of protein kinase P with polylysine inhibits this effectCell lines and peripheral blood leukocytes derived from individuals with chronic myelogenous leukemia display virtually identical proteins phosphorylated on tyrosine residuesModulation of protein kinase signaling cascades by palytoxin.Palytoxin: exploiting a novel skin tumor promoter to explore signal transduction and carcinogenesis.Correlation between hormone dependency and the regulation of epidermal growth factor receptor by tumor promoters in human mammary carcinoma cellsStimulation of ribosomal protein S6 kinase activity by pp60v-src or by serum: dissociation from phorbol ester-stimulated activityThe membrane-proximal intracellular domain of the epidermal growth factor receptor underlies negative cooperativity in ligand binding.EGF-stimulated tyrosine phosphorylation of p185neu: a potential model for receptor interactions.EGFR ligands drive multipotential stromal cells to produce multiple growth factors and cytokines via early growth response-1.Transforming growth factor-beta modulates the high-affinity receptors for epidermal growth factor and transforming growth factor-alphaAssociation of the epidermal growth factor receptor kinase with the detergent-insoluble cytoskeleton of A431 cells.Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: receptor pathwayDirect visualization of the phosphorylated epidermal growth factor receptor during its internalization in A-431 cellsCharacterization of a Drosophila protein that binds both epidermal growth factor and insulin-related growth factors.An insulin epidermal growth factor-binding protein from Drosophila has insulin-degrading activityAn evolutionarily conserved enzyme degrades transforming growth factor-alpha as well as insulinEpidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activationA negative feedback loop attenuates EGF-induced morphological changesActivation of insulin-epidermal growth factor (EGF) receptor chimerae regulates EGF receptor binding affinity.Oligomerization of epidermal growth factor receptors on A431 cells studied by time-resolved fluorescence imaging microscopy. A stereochemical model for tyrosine kinase receptor activationTumor promotion by depleting cells of protein kinase C delta.Rapid uptake of tyrphostin into A431 human epidermoid cells is followed by delayed inhibition of epidermal growth factor (EGF)-stimulated EGF receptor tyrosine kinase activity.The calcium signal for BALB/MK keratinocyte terminal differentiation counteracts epidermal growth factor (EGF) very early in the EGF-induced proliferative pathway.Release of a phorbol ester-induced mitogenic block by mutation at Thr-654 of the epidermal growth factor receptor.Mutation of a protein kinase C phosphorylation site in the erbB protein of avian erythroblastosis virus.Vaccinia virus growth factor stimulates tyrosine protein kinase activity of A431 cell epidermal growth factor receptors.Normal cellular and transformation-associated abl proteins share common sites for protein kinase C phosphorylation.
P2860
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P2860
Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor
description
1984 nî lūn-bûn
@nan
1984年の論文
@ja
1984年学术文章
@wuu
1984年学术文章
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1984年学术文章
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1984年学术文章
@zh-my
1984年学术文章
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1984年學術文章
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1984年學術文章
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1984年學術文章
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name
Tumor promoters block tyrosine ...... idermal growth factor receptor
@ast
Tumor promoters block tyrosine ...... idermal growth factor receptor
@en
type
label
Tumor promoters block tyrosine ...... idermal growth factor receptor
@ast
Tumor promoters block tyrosine ...... idermal growth factor receptor
@en
prefLabel
Tumor promoters block tyrosine ...... idermal growth factor receptor
@ast
Tumor promoters block tyrosine ...... idermal growth factor receptor
@en
P2093
P2860
P356
P1476
Tumor promoters block tyrosine ...... idermal growth factor receptor
@en
P2093
A R Frackelton
B Friedman
J M Connors
M R Rosner
T Sugimura
P2860
P304
P356
10.1073/PNAS.81.10.3034
P407
P577
1984-05-01T00:00:00Z