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Requirement of the MRN complex for ATM activation by DNA damage

Requirement of the MRN complex for ATM activation by DNA damage

http://www.wikidata.org/entity/Q36267304

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Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication Nijmegen breakage syndrome (NBS)Human single-stranded DNA binding proteins are essential for maintaining genomic stability Functional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK catalytic subunit The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway ATM activation by ionizing radiation requires BRCA1-associated BAAT1 ATM-dependent phosphorylation of ATF2 is required for the DNA damage response ATMIN defines an NBS1-independent pathway of ATM signalling Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination Involvement of human MOF in ATM function Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention Multiple roles of ATM in monitoring and maintaining DNA integrity Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity Common mechanisms of PIKK regulation ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain Rapid activation of ATR by ionizing radiation requires ATM and Mre11 Bacillus subtilis RecN binds and protects 3'-single-stranded DNA extensions in the presence of ATP.Mre11 assembles linear DNA fragments into DNA damage signaling complexes The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response Ubc13: the Lys63 ubiquitin chain building machine Connecting Malfunctioning Glial Cells and Brain Degenerative Disorders Evaluating biomarkers to model cancer risk post cosmic ray exposure A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to Adaptor Novel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2 The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair Chromatin perturbations during the DNA damage response in higher eukaryotes RNF20-SNF2H Pathway of Chromatin Relaxation in DNA Double-Strand Break Repair Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising Transcriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, inducible responses and genotoxic adaptation Causal link between microsatellite instability and hMRE11 dysfunction in human cancers Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors.DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.DNA-PK autophosphorylation facilitates Artemis endonuclease activity Ubiquitylation, neddylation and the DNA damage response

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Requirement of the MRN complex for ATM activation by DNA damage

http://www.wikidata.org/entity/Q36267304

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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2003年學術文章

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Requirement of the MRN complex for ATM activation by DNA damage

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Requirement of the MRN complex for ATM activation by DNA damage

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Requirement of the MRN complex for ATM activation by DNA damage

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Requirement of the MRN complex for ATM activation by DNA damage

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Requirement of the MRN complex for ATM activation by DNA damage

@ast

Requirement of the MRN complex for ATM activation by DNA damage

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The EMBO Journal

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Requirement of the MRN complex for ATM activation by DNA damage

@en

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Leonid Mittelman

http://www.w3.org/2001/XMLSchema#string

Lilach Moyal

http://www.w3.org/2001/XMLSchema#string

Tamar Uziel

http://www.w3.org/2001/XMLSchema#string

Yair Andegeko

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Yaniv Lerenthal

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Yosef Shiloh

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P2860

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

ATM-dependent phosphorylation of nibrin in response to radiation exposure

Chk2 activation dependence on Nbs1 after DNA damage

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

MDC1 is a mediator of the mammalian DNA damage checkpoint

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

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22

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14532133

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213795

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