E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk - Wikidata - wikimedia - TriplyDB

E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk

E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk

http://www.wikidata.org/entity/Q36274864

about

Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore The role of chromatin in adenoviral vector function Mechanisms of cancer cell killing by the adenovirus E4orf4 protein CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia The Human Adenovirus Type 5 E4orf4 Protein Targets Two Phosphatase Regulators of the Hippo Signaling Pathway The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response Structure- and modeling-based identification of the adenovirus E4orf4 binding site in the protein phosphatase 2A B55α subunit Adenovirus E4orf4 protein induces PP2A-dependent growth arrest in Saccharomyces cerevisiae and interacts with the anaphase-promoting complex/cyclosome.Adenovirus E4 open reading frame 4-induced apoptosis involves dysregulation of Src family kinases.Cytoplasmic death signal triggered by SRC-mediated phosphorylation of the adenovirus E4orf4 protein.Adenovirus E4orf4 hijacks rho GTPase-dependent actin dynamics to kill cells: a role for endosome-associated actin assembly.Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor.Localization and importance of the adenovirus E4orf4 protein during lytic infection Regulation of cell death by recycling endosomes and golgi membrane dynamics via a pathway involving Src-family kinases, Cdc42 and Rab11a.The adenovirus E4-ORF4 splicing enhancer protein interacts with a subset of phosphorylated SR proteins.Novel role for E4 region genes in protection of adenovirus vectors from lysis by cytotoxic T lymphocytes Immune evasion by adenoviruses.The cytosolic tail of the Golgi apyrase Ynd1 mediates E4orf4-induced toxicity in Saccharomyces cerevisiae.The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis.Recombinant, replication-defective adenovirus gene transfer vectors induce cell cycle dysregulation and inappropriate expression of cyclin proteins.Induction of p53-independent apoptosis by the adenovirus E4orf4 protein requires binding to the Balpha subunit of protein phosphatase 2A.Adenovirus-mediated p21((WAF1/SDII/CIP1)) gene transfer induces apoptosis of human cervical cancer cell lines.Regulation of adenovirus-mediated transgene expression by the viral E4 gene products: requirement for E4 ORF3.Induction of transformation and p53-dependent apoptosis by adenovirus type 5 E4orf6/7 cDNA.Resistance to tumor necrosis factor-induced cell death mediated by PMCA4 deficiency.Adenovirus E3-6.7K maintains calcium homeostasis and prevents apoptosis and arachidonic acid release.Genetic analysis of B55alpha/Cdc55 protein phosphatase 2A subunits: association with the adenovirus E4orf4 protein.The role of adenovirus E4orf4 protein in viral replication and cell killing.Light-induced retinal ganglion cell damage in vivo involves Dexras1.Adenovirus infection of primary malignant lymphoid cells.Interaction of adenovirus type 5 E4orf4 with the nuclear pore subunit Nup205 is required for proper viral gene expression.Role of factors downstream of caspases in nuclear disassembly during apoptotic execution.Adenovirus replaces mitotic checkpoint controls.Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A.Transition from caspase-dependent to caspase-independent mechanisms at the onset of apoptotic execution.Inactivating intracellular antiviral responses during adenovirus infection.Distinct cell death pathways triggered by the adenovirus early region 4 ORF 4 protein.E4orf4 induces PP2A- and Src-dependent cell death in Drosophila melanogaster and at the same time inhibits classic apoptosis pathways.The adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit.

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E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk

http://www.wikidata.org/entity/Q36274864

description

1998 nî lūn-bûn

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1998年の論文

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1998年学术文章

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E4orf4, a novel adenovirus dea ...... t is not inhibited by zVAD-fmk

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E4orf4, a novel adenovirus dea ...... t is not inhibited by zVAD-fmk

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E4orf4, a novel adenovirus dea ...... t is not inhibited by zVAD-fmk

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G C Shore

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J N Lavoie

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M Nguyen

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P E Branton

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P2860

p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27

Regulation of apoptosis by viral gene products

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme

Apoptosis in the pathogenesis and treatment of disease

Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

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277464441

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9456323

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P921

apoptotic process

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2140159

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