Adenovirus E4orf4 protein induces PP2A-dependent growth arrest in Saccharomyces cerevisiae and interacts with the anaphase-promoting complex/cyclosome.
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Zds2p regulates Swe1p-dependent polarized cell growth in Saccharomyces cerevisiae via a novel Cdc55p interaction domain.Mechanisms of cancer cell killing by the adenovirus E4orf4 proteinViral infections and cell cycle G2/M regulationThe Human Adenovirus Type 5 E4orf4 Protein Targets Two Phosphatase Regulators of the Hippo Signaling PathwayThe Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage ResponseStructure- and modeling-based identification of the adenovirus E4orf4 binding site in the protein phosphatase 2A B55α subunitCytoplasmic death signal triggered by SRC-mediated phosphorylation of the adenovirus E4orf4 protein.Adenovirus E4orf4 hijacks rho GTPase-dependent actin dynamics to kill cells: a role for endosome-associated actin assembly.Localization and importance of the adenovirus E4orf4 protein during lytic infectionAnalysis by live imaging of effects of the adenovirus E4orf4 protein on passage through mitosis of H1299 tumor cells.Apoptosis induced by environmental stresses and amphotericin B in Candida albicans.The cytosolic tail of the Golgi apyrase Ynd1 mediates E4orf4-induced toxicity in Saccharomyces cerevisiae.Accumulation of substrates of the anaphase-promoting complex (APC) during human cytomegalovirus infection is associated with the phosphorylation of Cdh1 and the dissociation and relocalization of APC subunits.Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a.Low-dose paclitaxel synergizes with oncolytic adenoviruses via mitotic slippage and apoptosis in ovarian cancer.Genetic analysis of B55alpha/Cdc55 protein phosphatase 2A subunits: association with the adenovirus E4orf4 protein.Interaction of adenovirus type 5 E4orf4 with the nuclear pore subunit Nup205 is required for proper viral gene expression.Adenovirus replaces mitotic checkpoint controls.Changing the ubiquitin landscape during viral manipulation of the DNA damage response.Distinct cell death pathways triggered by the adenovirus early region 4 ORF 4 protein.Cdc55p-mediated E4orf4 growth inhibition in Saccharomyces cerevisiae is mediated only in part via the catalytic subunit of protein phosphatase 2A.E4orf4 induces PP2A- and Src-dependent cell death in Drosophila melanogaster and at the same time inhibits classic apoptosis pathways.Viral manipulation of DNA repair and cell cycle checkpointsThe adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit.Targeting the anaphase promoting complex: common pathways for viral infection and cancer therapy.Viral takeover of the host ubiquitin system.Virus manipulation of cell cycle.Control the host cell cycle: viral regulation of the anaphase-promoting complex.Viral genes as oncolytic agents for cancer therapy.The viral protein Apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53.Identification of the adenovirus E4orf4 protein binding site on the B55α and Cdc55 regulatory subunits of PP2A: Implications for PP2A function, tumor cell killing and viral replication.Adenovirus E4orf4 protein-induced death of p53-/- H1299 human cancer cells follows a G1 arrest of both tetraploid and diploid cells due to a failure to initiate DNA synthesis.Nonstructural protein σ1s mediates reovirus-induced cell cycle arrest and apoptosis.Adenovirus E4orf4 protein downregulates MYC expression through interaction with the PP2A-B55 subunit.Human Gyrovirus-Apoptin Interferes with the Cell Cycle and Induces G2/M Arrest Prior to Apoptosis.Apoptin nucleocytoplasmic shuttling is required for cell type-specific localization, apoptosis, and recruitment of the anaphase-promoting complex/cyclosome to PML bodies.Adenovirus protein E4orf4 induces premature APCCdc20 activation in Saccharomyces cerevisiae by a protein phosphatase 2A-dependent mechanismYND1 interacts with CDC55 and is a novel mediator of E4orf4-induced toxicity.Nuclear localization of the adenovirus E4orf4 protein is mediated through an arginine-rich motif and correlates with cell death.
P2860
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P2860
Adenovirus E4orf4 protein induces PP2A-dependent growth arrest in Saccharomyces cerevisiae and interacts with the anaphase-promoting complex/cyclosome.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Adenovirus E4orf4 protein indu ...... e-promoting complex/cyclosome.
@ast
Adenovirus E4orf4 protein indu ...... e-promoting complex/cyclosome.
@en
type
label
Adenovirus E4orf4 protein indu ...... e-promoting complex/cyclosome.
@ast
Adenovirus E4orf4 protein indu ...... e-promoting complex/cyclosome.
@en
prefLabel
Adenovirus E4orf4 protein indu ...... e-promoting complex/cyclosome.
@ast
Adenovirus E4orf4 protein indu ...... e-promoting complex/cyclosome.
@en
P2093
P2860
P356
P1476
Adenovirus E4orf4 protein indu ...... e-promoting complex/cyclosome.
@en
P2093
D Kornitzer
T Kleinberger
P2860
P304
P356
10.1083/JCB.200104104
P407
P577
2001-07-01T00:00:00Z