MeCP2 is critical for maintaining mature neuronal networks and global brain anatomy during late stages of postnatal brain development and in the mature adult brain.
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Recent advances in understanding synaptic abnormalities in Rett syndromeIn Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric DisordersMeCP2 post-translational modifications: a mechanism to control its involvement in synaptic plasticity and homeostasis?Dendritic spine dysgenesis in autism related disordersBDNF deregulation in Rett syndromeGABA and glutamate pathways are spatially and developmentally affected in the brain of Mecp2-deficient miceA Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Methyl-CpG binding protein 2 (MeCP2) localizes at the centrosome and is required for proper mitotic spindle organizationDifferential maturation of vesicular glutamate and GABA transporter expression in the mouse auditory forebrain during the first weeks of hearingMicroglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expressionMechanisms of Functional Hypoconnectivity in the Medial Prefrontal Cortex of Mecp2 Null Mice.MECP2 regulates cortical plasticity underlying a learned behaviour in adult female micePotential primary roles of glial cells in the mechanisms of psychiatric disorders.Beyond Widespread Mecp2 Deletions to Model Rett Syndrome: Conditional Spatio-Temporal Knockout, Single-Point Mutations and Transgenic Rescue MicePreclinical research in Rett syndrome: setting the foundation for translational success.Improvement of the Rett syndrome phenotype in a MeCP2 mouse model upon treatment with levodopa and a dopa-decarboxylase inhibitormGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndromeCholesterol in the Pathogenesis of Alzheimer's, Parkinson's Diseases and Autism: Link to Synaptic DysfunctionThe Crucial Role of DNA Methylation and MeCP2 in Neuronal FunctionPrenatal exposure to valproic acid increases miR-132 levels in the mouse embryonic brainFunctional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome.DNA modifications in the mammalian brainDendritic spine dysgenesis in Rett syndrome.Alterations in the cholinergic system of brain stem neurons in a mouse model of Rett syndromeSystemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndromeNovel MeCP2 isoform-specific antibody reveals the endogenous MeCP2E1 expression in murine brain, primary neurons and astrocytes.Astrocyte-specific regulation of hMeCP2 expression in Drosophila.Synapse assembly and neurodevelopmental disordersMECP2e1 isoform mutation affects the form and function of neurons derived from Rett syndrome patient iPS cells.The methyl-CpG-binding domain (MBD) is crucial for MeCP2's dysfunction-induced defects in adult newborn neuronsApplying the ethoexperimental approach to neurodevelopmental syndrome research reveals exaggerated defensive behavior in Mecp2 mutant mice.Mouse models of neurodevelopmental disease of the basal ganglia and associated circuits.Human-specific regulation of MeCP2 levels in fetal brains by microRNA miR-483-5p.Increasing brain serotonin corrects CO2 chemosensitivity in methyl-CpG-binding protein 2 (Mecp2)-deficient miceNMDA receptor regulation prevents regression of visual cortical function in the absence of Mecp2.Acute and crucial requirement for MeCP2 function upon transition from early to late adult stages of brain maturationLoss of MeCP2 function is associated with distinct gene expression changes in the striatumThe presence of two rare genomic syndromes, 1q21 deletion and Xq28 duplication, segregating independently in a family with intellectual disability.Oligodendrocyte lineage cells contribute unique features to Rett syndrome neuropathologyRescue of behavioral and EEG deficits in male and female Mecp2-deficient mice by delayed Mecp2 gene reactivation.
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P2860
MeCP2 is critical for maintaining mature neuronal networks and global brain anatomy during late stages of postnatal brain development and in the mature adult brain.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
MeCP2 is critical for maintain ...... and in the mature adult brain.
@ast
MeCP2 is critical for maintain ...... and in the mature adult brain.
@en
type
label
MeCP2 is critical for maintain ...... and in the mature adult brain.
@ast
MeCP2 is critical for maintain ...... and in the mature adult brain.
@en
prefLabel
MeCP2 is critical for maintain ...... and in the mature adult brain.
@ast
MeCP2 is critical for maintain ...... and in the mature adult brain.
@en
P2093
P2860
P1476
MeCP2 is critical for maintain ...... and in the mature adult brain.
@en
P2093
Aparna Nigam
Christy A Felice
Gail Mandel
John K Robinson
Minh Vu Chuong Nguyen
Nurit Ballas
Xiwei Shan
P2860
P304
10021-10034
P356
10.1523/JNEUROSCI.1316-12.2012
P407
P577
2012-07-01T00:00:00Z