The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase
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Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symportersElevated CAIX Expression is Associated with an Increased Risk of Distant Failure in Early-Stage Cervical CancerLactate and malignant tumors: a therapeutic target at the end stage of glycolysisExtracellularly activatable nanocarriers for drug delivery to tumors.Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation.Novel pH-sensitive polyacetal-based block copolymers for controlled drug delivery.Expression and activity of carbonic anhydrase IX is associated with metabolic dysfunction in MDA-MB-231 breast cancer cellsRapid uptake of glucose and lactate, and not hypoxia, induces apoptosis in three-dimensional tumor tissue cultureCell surface lactate receptor GPR81 is crucial for cancer cell survival.Lactate transporters and vascular factors in HPV-induced squamous cell carcinoma of the uterine cervix.Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?Analysis and prediction of pathways in HeLa cells by integrating biological levels of organization with systems-biology approachesHuman phospholipase D activity transiently regulates pyrimidine biosynthesis in malignant gliomasHIF-1 at the crossroads of hypoxia, inflammation, and cancer.Tumor acidity, chemoresistance and proton pump inhibitors.Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis.Role of carbonic anhydrases in the progression of renal cell carcinoma subtypes: proposal of a unified hypothesis.Additive Influence of Extracellular pH, Oxygen Tension, and Pressure on Invasiveness and Survival of Human Osteosarcoma Cells.Significance of pH regulation and carbonic anhydrases in tumour progression and implications for diagnostic and therapeutic approaches.Recent progress in tumor pH targeting nanotechnology.G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion.Protons and Ca2+: ionic allies in tumor progression?Nanodelivery strategies in cancer chemotherapy: biological rationale and pharmaceutical perspectives.Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors.Prognostic impact of carbonic anhydrase IX expression in human renal cell carcinoma.Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway.Hypoxia and cellular metabolism in tumour pathophysiology.Synthesis of new N,N'-bis[1-aryl-3-(piperidine-1-yl)propylidene]hydrazine dihydrochlorides and evaluation of their cytotoxicity against human hepatoma and breast cancer cells.Rapid dissolution of ZnO nanocrystals in acidic cancer microenvironment leading to preferential apoptosis.Role of Na+/H+ exchanger in resveratrol-induced growth inhibition of human breast cancer cells.Stereocomplexes Formed From Select Oligomers of Polymer d-lactic Acid (PDLA) and l-lactate May Inhibit Growth of Cancer Cells and Help Diagnose Aggressive Cancers-Applications of the Warburg Effect.Osteoclast precursors display dynamic metabolic shifts toward accelerated glucose metabolism at an early stage of RANKL-stimulated osteoclast differentiation.Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma.Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia.pH modulation using CsCl enhances therapeutic effects of vitamin D in LNCaP tumor bearing mice.Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.Contributions of cell metabolism and H+ diffusion to the acidic pH of tumors.Phosphoinositide 3-kinase is involved in the tumor-specific activation of human breast cancer cell Na(+)/H(+) exchange, motility, and invasion induced by serum deprivation.Proliferating fibroblasts at the invading tumour edge of colorectal adenocarcinomas are associated with endogenous markers of hypoxia, acidity, and oxidative stress.An IkappaB-beta COOH terminal region protein is essential for the proliferation of CHO cells under acidic stress.
P2860
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P2860
The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
The contribution of lactic aci ...... lacking lactate dehydrogenase
@ast
The contribution of lactic aci ...... lacking lactate dehydrogenase
@en
type
label
The contribution of lactic aci ...... lacking lactate dehydrogenase
@ast
The contribution of lactic aci ...... lacking lactate dehydrogenase
@en
prefLabel
The contribution of lactic aci ...... lacking lactate dehydrogenase
@ast
The contribution of lactic aci ...... lacking lactate dehydrogenase
@en
P2093
P2860
P356
P1476
The contribution of lactic aci ...... lacking lactate dehydrogenase
@en
P2093
P2860
P2888
P304
P356
10.1038/BJC.1998.289
P407
P577
1998-06-01T00:00:00Z