Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties.

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Histone lysine methyltransferases as anti-cancer targets for drug discovery The upstreams and downstreams of H3K79 methylation by DOT1L.The extraordinary thermal stability of EstA from S. islandicus is independent of post translational modifications.

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Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties.

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2015年学术文章

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Dot1 histone methyltransferase ...... diverged catalytic properties.

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Dot1 histone methyltransferase ...... diverged catalytic properties.

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Dot1 histone methyltransferase ...... diverged catalytic properties.

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Dot1 histone methyltransferase ...... diverged catalytic properties.

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Dot1 histone methyltransferase ...... diverged catalytic properties.

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Dot1 histone methyltransferase ...... diverged catalytic properties.

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P1476

Dot1 histone methyltransferase ...... diverged catalytic properties

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P2093

Dirk De Vos

http://www.w3.org/2001/XMLSchema#string

Iris J E Stulemeijer

http://www.w3.org/2001/XMLSchema#string

Kirsten van Harten

http://www.w3.org/2001/XMLSchema#string

Marit Terweij

http://www.w3.org/2001/XMLSchema#string

Olga Blomberg

http://www.w3.org/2001/XMLSchema#string

Onkar K Joshi

http://www.w3.org/2001/XMLSchema#string

Tibor van Welsem

http://www.w3.org/2001/XMLSchema#string

P2860

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet.

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L

hDOT1L links histone methylation to leukemogenesis.

Reconstitution of yeast silent chromatin: multiple contact sites and O-AADPR binding load SIR complexes onto nucleosomes in vitro.

Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications

Misguided transcriptional elongation causes mixed lineage leukemia

The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis

Methylation of histone H3 on lysine 79 associates with a group of replication origins and helps limit DNA replication once per cell cycle

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srep09824

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9824

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10.1038/SREP09824

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English

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2015-05-12T00:00:00Z

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276465006

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25965993

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4650758

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Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties.

about

P2860

P2860

Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties.

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