Role of charged residues in the S1-S4 voltage sensor of BK channels.
about
Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability.Prestin's anion transport and voltage-sensing capabilities are independentRole of S3 and S4 transmembrane domain charged amino acids in channel biogenesis and gating of KCa2.3 and KCa3.1Voltage-gated proton channels: what's next?Slo3 K+ channels: voltage and pH dependence of macroscopic currentsBK channels: multiple sensors, one activation gateFunction and regulation of large conductance Ca(2+)-activated K+ channel in vascular smooth muscle cellsStudies of alpha-helicity and intersegmental interactions in voltage-gated Na+ channels: S2D4.A BK (Slo1) channel journey from molecule to physiology.Operation of the voltage sensor of a human voltage- and Ca2+-activated K+ channel.Coupling and cooperativity in voltage activation of a limited-state BK channel gating in saturating Ca2+.The regulation of BK channel activity by pre- and post-translational modifications.BK channel activation: structural and functional insightsPosition and motions of the S4 helix during opening of the Shaker potassium channel.Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channelLarge conductance, Ca2+-activated K+ channels (BKCa) and arteriolar myogenic signalingOrientations and proximities of the extracellular ends of transmembrane helices S0 and S4 in open and closed BK potassium channels.Single-channel kinetics of BK (Slo1) channels.Voltage-dependent conformational changes in human Ca(2+)- and voltage-activated K(+) channel, revealed by voltage-clamp fluorometry.Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus.Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region.Molecular mechanisms underlying the effect of the novel BK channel opener GoSlo: involvement of the S4/S5 linker and the S6 segment.Mg(2+) binding to open and closed states can activate BK channels provided that the voltage sensors are elevatedMolecular mechanism of pharmacological activation of BK channels.Regulation of Voltage-Activated K(+) Channel Gating by Transmembrane β Subunits.The contribution of RCK domains to human BK channel allosteric activationLarge conductance, calcium- and voltage-gated potassium (BK) channels: regulation by cholesterol.Relative transmembrane segment rearrangements during BK channel activation resolved by structurally assigned fluorophore-quencher pairing.Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channelsSingle Channel Recordings Reveal Differential β2 Subunit Modulations Between Mammalian and Drosophila BKCa(β2) Channels.An S6 mutation in BK channels reveals beta1 subunit effects on intrinsic and voltage-dependent gatingA role for the S0 transmembrane segment in voltage-dependent gating of BK channels.Modulation of the conductance-voltage relationship of the BK Ca channel by mutations at the putative flexible interface between two RCK domains.Mg2+ enhances voltage sensor/gate coupling in BK channels.Perspectives on: conformational coupling in ion channels: conformational coupling in BK potassium channels.Perspectives on: conformational coupling in ion channels: thermodynamics of electromechanical coupling in voltage-gated ion channels.Calcium activated K⁺ channels in the electroreceptor of the skate confirmed by cloning. Details of subunits and splicing.Free-energy relationships in ion channels activated by voltage and ligand.An extracellular Cu2+ binding site in the voltage sensor of BK and Shaker potassium channelsSubunit-specific effect of the voltage sensor domain on Ca2+ sensitivity of BK channels.
P2860
Q24338564-D2339A2D-8386-4C4E-9050-86C0F7A00E65Q24642622-A13A4A91-87D5-45DF-80B5-7C1658585820Q24652943-815D7276-A309-462C-A257-78ECD77996BFQ24657828-9588EC7E-DD0F-4403-836A-6AB7D7842614Q24684485-CEFB584D-5BEC-4E46-97F9-C31F2D152EA1Q26830341-ED4B35A6-FFF7-4F2D-85BD-E7221D28BC21Q26995779-F4F93575-7781-4985-996C-15B8B22C0976Q33514435-3CAA2A87-6C55-4FF6-ACF3-780FCE2EC658Q33702537-4721B837-3FAC-4C7A-9E95-9F0D14AB9811Q33732977-E23BDDED-AFA1-407D-B8F5-5EA6A85B9758Q33814269-DAF92CFB-887E-4586-A530-1E669A1F0449Q34077885-7E509316-34A8-4F53-AD2B-1EF988D59F8AQ34088616-630931DD-4054-4090-8D87-F2D1C47863E0Q34368444-D94C7F7A-912C-432F-94EA-FFED8B34DBBAQ34368477-27387CFF-E40C-4521-A7D0-4E54B5C1EBAAQ34475162-F9745756-2E11-4321-9C07-3BECB361240FQ34614933-D67DBD4D-6E60-4582-B110-D7ED61F702BDQ34991954-C83EC50D-94F4-4CBF-B512-ED3607C75C3FQ35033825-B2685C77-81EF-47A9-8A94-B66D60986860Q35063533-8866503E-D26B-4BFD-A8D6-389392271404Q35123192-6F3F4A7F-13A5-479A-9178-6BDC9519D17BQ35129015-F0F5D70E-536D-473A-9BCC-14C3C335498EQ35581373-8460A9D2-558E-4B5C-A5D6-47F53FFFE5F7Q35807499-BB9927D1-1B4F-4DB2-B44C-E68DA0C71978Q35893721-37475913-5EDA-4DEF-B456-1330466B6AD6Q36052381-556BEFEF-567C-44AA-8BA2-CAE3E10E6640Q36059310-B7AEBF1B-AFC0-4AC0-9A03-CB4F76D6DB58Q36130322-24D66D0C-9973-4BA6-8FA7-EBAE264A3775Q36156951-CD6B9F39-D2F8-4883-A1F6-B567DA4D0032Q36166100-9E50F724-35CF-4E9B-AEB7-89AAADEF9F8FQ36295951-E598F103-60F4-4255-BC77-C36B4581429BQ36295991-7DFB3273-F051-4A8B-9BD4-737A15D5749FQ36303199-FA2AC03A-4855-4ACE-9100-3A7B314988DDQ36325854-E9ED5738-57A1-4CCF-B3D7-3CA8F3EE13C7Q36446389-D316655E-6104-442C-ABAB-869C00FE951AQ36446427-15830640-52E7-481B-96C7-BDF0E53562ABQ36494784-C066D7EB-23DE-4C75-86A8-9112CA18BDA4Q36507221-43F22E24-86BC-4F75-BA46-DFFC321CE211Q36593661-83CA4FF2-165E-4B8F-8943-7443CD49EE20Q36678098-A29F27A4-EF3F-41F3-AF65-9720F32F2A25
P2860
Role of charged residues in the S1-S4 voltage sensor of BK channels.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Role of charged residues in the S1-S4 voltage sensor of BK channels.
@ast
Role of charged residues in the S1-S4 voltage sensor of BK channels.
@en
type
label
Role of charged residues in the S1-S4 voltage sensor of BK channels.
@ast
Role of charged residues in the S1-S4 voltage sensor of BK channels.
@en
prefLabel
Role of charged residues in the S1-S4 voltage sensor of BK channels.
@ast
Role of charged residues in the S1-S4 voltage sensor of BK channels.
@en
P2093
P2860
P356
P1476
Role of charged residues in the S1-S4 voltage sensor of BK channels.
@en
P2093
Frank T Horrigan
Xing Jian Lou
Zhongming Ma
P2860
P304
P356
10.1085/JGP.200509421
P577
2006-03-01T00:00:00Z