Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure
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Fatty old hearts: role of cardiac lipotoxicity in age-related cardiomyopathyAdiponectin resistance in skeletal muscle: pathophysiological implications in chronic heart failureThe role of metabolic syndrome in heart failureCardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunctionInsulin Signaling and Heart Failure.Assessment of myocardial viability and left ventricular function in patients supported by a left ventricular assist deviceEvidence of Glycolysis Up-Regulation and Pyruvate Mitochondrial Oxidation Mismatch During Mechanical Unloading of the Failing Human Heart: Implications for Cardiac Reloading and ConditioningImpact of diabetes on survival and right ventricular compensation in pulmonary arterial hypertension.Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts.Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure.Dietary high-fat lard intake induces thyroid dysfunction and abnormal morphology in ratsDietary fat supply to failing hearts determines dynamic lipid signaling for nuclear receptor activation and oxidation of stored triglyceride.Sheet-Like Remodeling of the Transverse Tubular System in Human Heart Failure Impairs Excitation-Contraction Coupling and Functional Recovery by Mechanical Unloading.Ventricular assist device implantation improves skeletal muscle function, oxidative capacity, and growth hormone/insulin-like growth factor-1 axis signaling in patients with advanced heart failureRestoring redox balance enhances contractility in heart trabeculae from type 2 diabetic rats exposed to high glucose.Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicityKLF15 and PPARα Cooperate to Regulate Cardiomyocyte Lipid Gene Expression and Oxidation.Resolving confounding enrichment kinetics due to overlapping resonance signals from 13C-enriched long chain fatty acid oxidation and uptake within intact hearts.Genetic manipulation of cardiac Hsp72 levels does not alter substrate metabolism but reveals insights into high-fat feeding-induced cardiac insulin resistanceCeramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylationKruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis.Mechanisms of lipotoxicity in the cardiovascular system.Adipose tissue biology and cardiomyopathy: translational implications.Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.Supplementation of l-Alanyl-l-Glutamine and Fish Oil Improves Body Composition and Quality of Life in Patients With Chronic Heart Failure.Ketones Step to the Plate: A Game Changer for Metabolic Remodeling in Heart Failure?Cardiac lipotoxicity: molecular pathways and therapeutic implications.Acyl CoA synthetase-1 links facilitated long chain fatty acid uptake to intracellular metabolic trafficking differently in hearts of male versus female mice.Animal models of insulin resistance and heart failure.Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac FunctionEarly structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablation.Obesity and Cardiac Function - The Role of Caloric Excess and its Reversal.Analysis of the correlation between lipotoxicity and pituitary-thyroid axis hormone levels in men and male rats.Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.Kruppel-like factor 15 is a critical regulator of cardiac lipid metabolismLipoprotein lipase activity is required for cardiac lipid droplet production.Lipid Use and Misuse by the Heart.Recovery of Serum Cholesterol Predicts Survival After Left Ventricular Assist Device ImplantationCellular cross-talk between epicardial adipose tissue and myocardium in relation to the pathogenesis of cardiovascular disease.Adiponectin: key role and potential target to reverse energy wasting in chronic heart failure.
P2860
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P2860
Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
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2012年學術文章
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name
Ventricular assist device impl ...... ts with advanced heart failure
@ast
Ventricular assist device impl ...... ts with advanced heart failure
@en
type
label
Ventricular assist device impl ...... ts with advanced heart failure
@ast
Ventricular assist device impl ...... ts with advanced heart failure
@en
prefLabel
Ventricular assist device impl ...... ts with advanced heart failure
@ast
Ventricular assist device impl ...... ts with advanced heart failure
@en
P2093
P2860
P1433
P1476
Ventricular assist device impl ...... ts with advanced heart failure
@en
P2093
Christine S Chung
Donna M Mancini
Faisal H Cheema
Hendrik Milting
Hiroo Takayama
Ira J Goldberg
Konstantinos Drosatos
P Christian Schulze
Raffay Khan
Ruiping Ji
P2860
P304
P356
10.1161/CIRCULATIONAHA.111.060889
P407
P577
2012-05-14T00:00:00Z