A flexible multidomain structure drives the function of the urokinase-type plasminogen activator receptor (uPAR)
about
Mapping the topographic epitope landscape on the urokinase plasminogen activator receptor (uPAR) by surface plasmon resonance and X-ray crystallographyUniqueness of models from small-angle scattering data: the impact of a hydration shell and complementary NMR restraints.Probing binding and cellular activity of pyrrolidinone and piperidinone small molecules targeting the urokinase receptor.Multimerization of glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) and familial chylomicronemia from a serine-to-cysteine substitution in GPIHBP1 Ly6 domainAdministration of recombinant soluble urokinase receptor per se is not sufficient to induce podocyte alterations and proteinuria in miceSmall-molecule inhibition of the uPAR·uPA interaction: synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis.Improved PET imaging of uPAR expression using new (64)Cu-labeled cross-bridged peptide ligands: comparative in vitro and in vivo studies.A new class of orthosteric uPAR·uPA small-molecule antagonists are allosteric inhibitors of the uPAR·vitronectin interactionThe acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain.Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancerThe urokinase receptor homolog Haldisin is a novel differentiation marker of stratum granulosum in squamous epithelia.Structure-driven design of radionuclide tracers for non-invasive imaging of uPAR and targeted radiotherapy. The tale of a synthetic peptide antagonist.ATSAS 2.8: a comprehensive data analysis suite for small-angle scattering from macromolecular solutionsAdvanced ensemble modelling of flexible macromolecules using X-ray solution scattering.Combining NMR and small angle X-ray scattering for the study of biomolecular structure and dynamics.Soluble Urokinase Plasminogen Activator Receptor Is a Predictor of Incident Non-AIDS Comorbidity and All-Cause Mortality in Human Immunodeficiency Virus Type 1 Infection.Discovery of novel urokinase plasminogen activator (uPA) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis.Urokinase receptor cleavage correlates with tumor volume in a transgenic mouse model of breast cancer.
P2860
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P2860
A flexible multidomain structure drives the function of the urokinase-type plasminogen activator receptor (uPAR)
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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name
A flexible multidomain structu ...... ogen activator receptor (uPAR)
@ast
A flexible multidomain structu ...... ogen activator receptor (uPAR)
@en
type
label
A flexible multidomain structu ...... ogen activator receptor (uPAR)
@ast
A flexible multidomain structu ...... ogen activator receptor (uPAR)
@en
prefLabel
A flexible multidomain structu ...... ogen activator receptor (uPAR)
@ast
A flexible multidomain structu ...... ogen activator receptor (uPAR)
@en
P2860
P50
P356
P1476
A flexible multidomain structu ...... ogen activator receptor (uPAR)
@en
P2093
Henrik Gårdsvoll
P2860
P304
34304-34315
P356
10.1074/JBC.M112.398404
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P577
2012-08-15T00:00:00Z