Discovery of novel urokinase plasminogen activator (uPA) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis.
about
Simulated annealing molecular dynamics and ligand-receptor contacts analysis for pharmacophore modeling.Combining docking-based comparative intermolecular contacts analysis and k-nearest neighbor correlation for the discovery of new check point kinase 1 inhibitors.Unsupervised pharmacophore modeling combined with QSAR analyses revealed novel low micromolar SIRT2 inhibitors.Discovery of novel potent nuclear factor kappa-B inhibitors (IKK-β) via extensive ligand-based modeling and virtual screening.Combining molecular dynamics simulation and ligand-receptor contacts analysis as a new approach for pharmacophore modeling: beta-secretase 1 and check point kinase 1 as case studies.
P2860
Discovery of novel urokinase plasminogen activator (uPA) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis.
description
2014 nî lūn-bûn
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年學術文章
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name
Discovery of novel urokinase p ...... followed by in vitro analysis.
@en
Discovery of novel urokinase plasminogen activator
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type
label
Discovery of novel urokinase p ...... followed by in vitro analysis.
@en
Discovery of novel urokinase plasminogen activator
@nl
prefLabel
Discovery of novel urokinase p ...... followed by in vitro analysis.
@en
Discovery of novel urokinase plasminogen activator
@nl
P2860
P50
P1476
Discovery of novel urokinase p ...... followed by in vitro analysis
@en
P2093
Mohammad A Khanfar
P2860
P2888
P356
10.1007/S00894-014-2080-4
P577
2014-01-28T00:00:00Z