Analysis of glutamine dependency in non-small cell lung cancer: GLS1 splice variant GAC is essential for cancer cell growth.
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Glutamine and cancer: cell biology, physiology, and clinical opportunitiesMetabolic rewiring in melanomaMechanistic Basis of Glutaminase Activation: A KEY ENZYME THAT PROMOTES GLUTAMINE METABOLISM IN CANCER CELLSAnalysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma.Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegenerationA novel glutaminase inhibitor-968 inhibits the migration and proliferation of non-small cell lung cancer cells by targeting EGFR/ERK signaling pathway.From Krebs to clinic: glutamine metabolism to cancer therapy.Upregulated SLC1A5 promotes cell growth and survival in colorectal cancerMesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibitionMechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells.Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibitionRole and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer.Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines.Cancer-Specific Production of N-Acetylaspartate via NAT8L Overexpression in Non-Small Cell Lung Cancer and Its Potential as a Circulating Biomarker.Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung CancerInhibition of mitochondrial glutaminase activity reverses acquired erlotinib resistance in non-small cell lung cancerPyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-DioxinMYC, metabolism, cell growth, and tumorigenesis.Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertensionAltered glutamine metabolism in platinum resistant ovarian cancer.Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic targetDual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLCStructural basis for exploring the allosteric inhibition of human kidney type glutaminase.Altered glutamine metabolism and therapeutic opportunities for lung cancer.Glutaminase regulation in cancer cells: a druggable chain of events.Cancer metabolomics in basic science perspective.Knockdown of PKM2 and GLS1 expression can significantly reverse oxaliplatin-resistance in colorectal cancer cells.A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in the development and progression of diverse tumors.A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis.1,25-Dihydroxyvitamin D inhibits glutamine metabolism in Harvey-ras transformed MCF10A human breast epithelial cell.Blockage of glutaminolysis enhances the sensitivity of ovarian cancer cells to PI3K/mTOR inhibition involvement of STAT3 signaling.Tumour-Derived Glutamate: Linking Aberrant Cancer Cell Metabolism to Peripheral Sensory Pain PathwaysA clinically attainable dose of L-asparaginase targets glutamine addiction in lymphoid cell lines.Targeting glutamine metabolism in myeloproliferative neoplasms.Integrated Metabolomics and Proteomics Highlight Altered Nicotinamide- and Polyamine Pathways in Lung Adenocarcinoma.Hopefully devoted to Q: targeting glutamine addiction in cancer.Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine.Glutaminase expression is a poor prognostic factor in node-positive triple-negative breast cancer patients with a high level of tumor-infiltrating lymphocytes.Glutaminase inhibitor CB-839 synergizes with carfilzomib in resistant multiple myeloma cells.
P2860
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P2860
Analysis of glutamine dependency in non-small cell lung cancer: GLS1 splice variant GAC is essential for cancer cell growth.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Analysis of glutamine dependen ...... ential for cancer cell growth.
@ast
Analysis of glutamine dependen ...... ential for cancer cell growth.
@en
type
label
Analysis of glutamine dependen ...... ential for cancer cell growth.
@ast
Analysis of glutamine dependen ...... ential for cancer cell growth.
@en
prefLabel
Analysis of glutamine dependen ...... ential for cancer cell growth.
@ast
Analysis of glutamine dependen ...... ential for cancer cell growth.
@en
P2093
P2860
P356
P1476
Analysis of glutamine dependen ...... ential for cancer cell growth.
@en
P2093
A Pieter J van den Heuvel
Junping Jing
Richard F Wooster
P2860
P304
P356
10.4161/CBT.21348
P50
P577
2012-08-15T00:00:00Z