Smad3 is key to TGF-beta-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis.
about
Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signalingThe basics of epithelial-mesenchymal transitionAxin and GSK3- control Smad3 protein stability and modulate TGF- signalingSIRT1 and Kidney FunctionDEAR1, a novel tumor suppressor that regulates cell polarity and epithelial plasticityTransforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer ProgressionSevere acute respiratory syndrome-associated coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-beta signalingTGFβ signalling in contextEmodin suppresses silica-induced lung fibrosis by promoting Sirt1 signaling via direct contactNoncanonical TGF-beta pathways, mTORC1 and Abl, in renal interstitial fibrogenesisLoss of BRMS1 promotes a mesenchymal phenotype through NF-κB-dependent regulation of Twist1.Pulmonary sequelae in a patient recovered from swine flu.Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP).The RhoA activator GEF-H1/Lfc is a transforming growth factor-beta target gene and effector that regulates alpha-smooth muscle actin expression and cell migrationGenetic variation in the TGF-β signaling pathway and colon and rectal cancer risk.Single-Molecule Imaging Reveals the Activation Dynamics of Intracellular Protein Smad3 on Cell Membrane.Liver cancer-derived hepatitis C virus core proteins shift TGF-beta responses from tumor suppression to epithelial-mesenchymal transitionNovel sequential ChIP and simplified basic ChIP protocols for promoter co-occupancy and target gene identification in human embryonic stem cells.HRD1-Mediated IGF-1R Ubiquitination Contributes to Renal Protection of Resveratrol in db/db Mice.Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3Targeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells.The Chinese medicine, Jianpi Huayu Decoction, inhibits the epithelial mesenchymal transition via the regulation of the Smad3/Smad7 cascade.Anchoring hepatic gene expression with development of fibrosis and neoplasia in a toxicant-induced fish model of liver injuryHigh throughput determination of TGFβ1/SMAD3 targets in A549 lung epithelial cellsTargeting the Transforming Growth Factor-beta pathway inhibits human basal-like breast cancer metastasis.HSP72 attenuates renal tubular cell apoptosis and interstitial fibrosis in obstructive nephropathy.Suppression of injury-induced epithelial-mesenchymal transition in a mouse lens epithelium lacking tenascin-CEpithelial origin of myofibroblasts during fibrosis in the lung.Grape seed pro-anthocyanidins ameliorates radiation-induced lung injury.Role of alphavbeta6 integrin in acute biliary fibrosisTGF-beta receptor deletion in the renal collecting system exacerbates fibrosis.Molecular mechanisms and treatment of radiation-induced lung fibrosisRadiation therapy causes loss of dermal lymphatic vessels and interferes with lymphatic function by TGF-beta1-mediated tissue fibrosis.Transforming growth factor-{beta}1 induces Smad3-dependent {beta}1 integrin gene expression in epithelial-to-mesenchymal transition during chronic tubulointerstitial fibrosis.Transforming growth factor-beta and fibrosisSmad2 protects against TGF-beta/Smad3-mediated renal fibrosis.HDAC6 deacetylase activity is required for hypoxia-induced invadopodia formation and cell invasion.Beta-elemene blocks epithelial-mesenchymal transition in human breast cancer cell line MCF-7 through Smad3-mediated down-regulation of nuclear transcription factors.The four-herb Chinese medicine ANBP enhances wound healing and inhibits scar formation via bidirectional regulation of transformation growth factor pathway.Accelerating repaired basement membrane after bevacizumab treatment on alkali-burned mouse cornea.
P2860
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P2860
Smad3 is key to TGF-beta-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Smad3 is key to TGF-beta-media ...... or suppression and metastasis.
@ast
Smad3 is key to TGF-beta-media ...... or suppression and metastasis.
@en
type
label
Smad3 is key to TGF-beta-media ...... or suppression and metastasis.
@ast
Smad3 is key to TGF-beta-media ...... or suppression and metastasis.
@en
prefLabel
Smad3 is key to TGF-beta-media ...... or suppression and metastasis.
@ast
Smad3 is key to TGF-beta-media ...... or suppression and metastasis.
@en
P2093
P1476
Smad3 is key to TGF-beta-media ...... mor suppression and metastasis
@en
P2093
Akira Ooshima
Kathleen C Flanders
Shizuya Saika
Stacey DaCosta Byfield
P356
10.1016/J.CYTOGFR.2005.09.008
P577
2005-11-11T00:00:00Z