Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence. - Wikidata - wikimedia - TriplyDB

Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence.

Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence.

http://www.wikidata.org/entity/Q36313879

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Oxidative stress, mitochondrial dysfunction, and aging Identification of 5-Iodotubercidin as a genotoxic drug with anti-cancer potential SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage.Nontelomeric role for Rap1 in regulating metabolism and protecting against obesity.Molecular targeting of TRF2 suppresses the growth and tumorigenesis of glioblastoma stem cells.The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection.Unraveling the pathogenesis of Hoyeraal-Hreidarsson syndrome, a complex telomere biology disorder Gene expression levels of human shelterin complex and shelterin-associated factors regulated by the topoisomerase II inhibitors doxorubicin and etoposide in human cultured cells.ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2.p53 governs telomere regulation feedback too, via TRF2.A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds.Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression.Gene expression analysis of whole blood, peripheral blood mononuclear cells, and lymphoblastoid cell lines from the Framingham Heart Study.Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation.HULC cooperates with MALAT1 to aggravate liver cancer stem cells growth through telomere repeat-binding factor 2.Chromatin structure in telomere dynamics Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway.DNA damage accumulation and TRF2 degradation in atypical Werner syndrome fibroblasts with LMNA mutations.Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation Heparan sulfation is essential for the prevention of cellular senescence.Posttranslational control of telomere maintenance and the telomere damage response.Fusing telomeres with RNF8.Regulators and effectors of Siah ubiquitin ligases.Transcriptional outcome of telomere signalling.PIAS1-mediated sumoylation promotes STUbL-dependent proteasomal degradation of the human telomeric protein TRF2.TRF2-mediated stabilization of hREST4 is critical for the differentiation and maintenance of neural progenitors.Methylated TRF2 associates with the nuclear matrix and serves as a potential biomarker for cellular senescence.p300-mediated acetylation of TRF2 is required for maintaining functional telomeres.Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence.Ubiquitination and SUMOylation in Telomere Maintenance and Dysfunction.TIN2 stability is regulated by the E3 ligase Siah2.Retrotransposon-derived p53 binding sites enhance telomere maintenance and genome protection.Differential senescence capacities in meibomian gland carcinoma and basal cell carcinoma.The transcription factor MEF/Elf4 is dually modulated by p53-MDM2 axis and MEF-MDM2 autoregulatory mechanism.Seven in Absentia E3 Ubiquitin Ligases: Central Regulators of Neural Cell Fate and Neuronal Polarity.Mutations in XLF/NHEJ1/Cernunnos gene results in downregulation of telomerase genes expression and telomere shortening.Inducing stable reversion to achieve cancer control.Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence.A switch-like dynamic mechanism for the initiation of replicative senescence.Acute telomere deprotection prevents ongoing BFB cycles and rampant instability in p16INK4a-deficient epithelial cells.

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Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence.

http://www.wikidata.org/entity/Q36313879

description

2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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2010年學術文章

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2010年學術文章

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name

Positive feedback between p53 ...... lling and cellular senescence.

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Positive feedback between p53 ...... lling and cellular senescence.

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type

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Positive feedback between p53 ...... lling and cellular senescence.

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Positive feedback between p53 ...... lling and cellular senescence.

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Positive feedback between p53 ...... lling and cellular senescence.

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Positive feedback between p53 ...... lling and cellular senescence.

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Nature Cell Biology

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Positive feedback between p53 ...... alling and cellular senescence

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P2093

Abdul M Mondal

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Borivoj Vojtesek

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Curtis C Harris

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Ettore Appella

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Izumi Horikawa

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Kaori Fujita

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Lisa M Miller Jenkins

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P2860

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

p53 isoforms can regulate p53 transcriptional activity.

POT1 and TRF2 cooperate to maintain telomeric integrity

Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins

Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation

SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1)

Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex

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1205-1212

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10.1038/NCB2123

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12

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12

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Jean-Christophe Bourdon

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2010-11-07T00:00:00Z

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47701350

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21057505

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3470109

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