Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation
about
Novel targeting of phosphatidylinositol 3-kinase and mammalian target of rapamycin in renal cell carcinomaMnk kinase pathway: Cellular functions and biological outcomesInhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E PathwayNutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signalingSustained proliferation in cancer: Mechanisms and novel therapeutic targetsRegulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signalingImage-based compound profiling reveals a dual inhibitor of tyrosine kinase and microtubule polymerizationPI3K and cancer: lessons, challenges and opportunitiesEnhancing mTOR-targeted cancer therapy.Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions.An internal ribosomal entry site mediates redox-sensitive translation of Nrf2.Targeting the translational machinery as a novel treatment strategy for hematologic malignanciesInhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approachThe efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 compared with rapamycin in renal cell carcinoma.Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development.Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E.The class I PI3K/Akt pathway is critical for cancer cell survival in dogs and offers an opportunity for therapeutic interventionThe evolution of the TOR pathway and its role in cancer.Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survivalPhosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches.Characterization of MNK1b DNA Aptamers That Inhibit Proliferation in MDA-MB231 Breast Cancer CellsPerifosine enhances mTORC1-targeted cancer therapy by activation of GSK3β in NSCLC cells.Adaptations to chronic rapamycin in mice.LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteinsTargeting the Mammalian Target of Rapamycin (mTOR) in Cancer Therapy: Lessons from Past and Future PerspectivesCGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway.Lithium down-regulates histone deacetylase 1 (HDAC1) and induces degradation of mutant huntingtin.4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression.Overcoming mTOR inhibition-induced paradoxical activation of survival signaling pathways enhances mTOR inhibitors' anticancer efficacy.MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.Malignant peripheral nerve sheath tumour (MPNST): the clinical implications of cellular signalling pathways.Perspectives on inhibiting mTOR as a future treatment strategy for hematological malignancies.The biological and therapeutic relevance of mRNA translation in cancer.New targeted therapies for renal cell carcinoma.Mechanisms of mTOR inhibitor resistance in cancer therapy.Targeting Mnks for cancer therapy.Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.Tissue microarray evidence of association between p16 and phosphorylated eIF4E in tonsillar squamous cell carcinoma.Dual abrogation of MNK and mTOR: a novel therapeutic approach for the treatment of aggressive cancers.
P2860
Q26829730-DFC103C4-134A-41C2-8D62-D3205D7C3E78Q26865459-F5FDE91B-5775-4623-8AAA-558B5A469D80Q27318237-B8AF4869-4883-4A43-A94B-6D616D01C835Q28307009-6E4E310E-D27C-4A3F-BC33-E33E5629530CQ28396388-AAA8904E-05EC-46F1-8D2C-52D35CB5FC93Q28475546-BB0603B8-56B4-4211-8C4D-9D7CB7B70CD7Q28834113-54852F9D-DE75-4CDE-89CE-01DE05FFD845Q30080017-752E0413-19D7-4200-9A50-CC8A02BC4B4EQ33604979-4327D92E-88B8-4640-B52D-6BCA3A8C906BQ33633701-AE0C0673-7F36-462E-94CD-3FF1550B2D77Q33633725-7C346BCB-5893-4D16-BABB-1EA17F7DF813Q33747291-039D707E-28AB-49CA-A1B0-3F69375DB31CQ33925323-24ABBF6A-0B27-43E1-8F48-21D04E58E1DAQ34001234-B6ED0A2B-2C8F-45D7-A2C0-A8EC4A3E33C4Q34069663-DCA13009-98D3-435C-8780-C292C46C7BB1Q34177252-116BDE66-2D4C-4833-B3CD-1D0C31B0A21CQ34286759-9D0C5998-B6D2-4EC1-AB44-98678C358F42Q34318188-3472BD81-E2F3-4122-9F68-F051B03A6945Q34594617-94F45EAC-2650-47F6-81E0-5CF9B47D6F86Q34978844-B59A7D43-7CD2-4A24-A5A1-9F72670CEA91Q35553279-EA14EFFB-0C7F-48EA-9DE0-4B7EE99FEC50Q35885183-3D3817AF-9B9A-4C06-89F2-EA34250F2C64Q36289873-A10AB782-5BC6-4482-AFF7-62104823DEEDQ36945944-1DD0145E-BCA4-482E-B8AD-C4DA1234D12BQ36999520-108C70FB-28D8-4517-8374-B0F853E311BDQ37132788-8E3CCDC1-946E-4BE6-80D1-C19391E4612BQ37317400-E102EBDD-996D-41D6-909D-F599EBF8F401Q37368725-C18A952F-5887-4280-9328-D9D58EC9CE89Q37378827-DF13A035-53E8-472E-A1C8-6EF08A218166Q37389181-1F7579A5-627E-4C85-BB62-F406F27E903BQ37524253-0C32EF67-94E8-40C7-B823-5FCA044F7272Q37616238-FB63A423-7B8E-4280-856D-A9552F46A773Q37779489-31F22AFD-8CC5-4276-87AD-4995F014952CQ37848652-42F11982-CD2E-4FC8-A60F-815ABF2E9BF7Q37867122-F7C0FCB9-52A9-4B0A-9367-B08DB137F569Q37872670-AF2CBE56-A5E7-4108-9752-333E701B4A1FQ37990881-907C7FE5-F0BB-4BB1-9E35-6AFC8657ED93Q38212951-39CE37E6-0207-497F-BF3A-0F50D4E22DD8Q38408862-1ACCCB57-E216-45BB-A118-EFDA9A713A22Q38637354-ECFDEE5C-5EF0-4FC4-A268-232A01722D6F
P2860
Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Inhibition of mammalian target ...... tion factor 4E phosphorylation
@ast
Inhibition of mammalian target ...... tion factor 4E phosphorylation
@en
type
label
Inhibition of mammalian target ...... tion factor 4E phosphorylation
@ast
Inhibition of mammalian target ...... tion factor 4E phosphorylation
@en
prefLabel
Inhibition of mammalian target ...... tion factor 4E phosphorylation
@ast
Inhibition of mammalian target ...... tion factor 4E phosphorylation
@en
P2093
P2860
P356
P1476
Inhibition of mammalian target ...... tion factor 4E phosphorylation
@en
P2093
Chi-Bun Chan
Fadlo R Khuri
Keqiang Ye
Rie Watanabe-Fukunaga
Rikiro Fukunaga
Shi-Yong Sun
Takeshi Ueda
Xuerong Wang
P2860
P304
P356
10.1128/MCB.00760-07
P407
P577
2007-08-27T00:00:00Z