Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation - Wikidata - wikimedia - TriplyDB

Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation

Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation

http://www.wikidata.org/entity/Q36315668

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Novel targeting of phosphatidylinositol 3-kinase and mammalian target of rapamycin in renal cell carcinoma Mnk kinase pathway: Cellular functions and biological outcomes Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling Sustained proliferation in cancer: Mechanisms and novel therapeutic targets Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling Image-based compound profiling reveals a dual inhibitor of tyrosine kinase and microtubule polymerization PI3K and cancer: lessons, challenges and opportunities Enhancing mTOR-targeted cancer therapy.Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions.An internal ribosomal entry site mediates redox-sensitive translation of Nrf2.Targeting the translational machinery as a novel treatment strategy for hematologic malignancies Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach The efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 compared with rapamycin in renal cell carcinoma.Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development.Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E.The class I PI3K/Akt pathway is critical for cancer cell survival in dogs and offers an opportunity for therapeutic intervention The evolution of the TOR pathway and its role in cancer.Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches.Characterization of MNK1b DNA Aptamers That Inhibit Proliferation in MDA-MB231 Breast Cancer Cells Perifosine enhances mTORC1-targeted cancer therapy by activation of GSK3β in NSCLC cells.Adaptations to chronic rapamycin in mice.LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins Targeting the Mammalian Target of Rapamycin (mTOR) in Cancer Therapy: Lessons from Past and Future Perspectives CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway.Lithium down-regulates histone deacetylase 1 (HDAC1) and induces degradation of mutant huntingtin.4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression.Overcoming mTOR inhibition-induced paradoxical activation of survival signaling pathways enhances mTOR inhibitors' anticancer efficacy.MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.Malignant peripheral nerve sheath tumour (MPNST): the clinical implications of cellular signalling pathways.Perspectives on inhibiting mTOR as a future treatment strategy for hematological malignancies.The biological and therapeutic relevance of mRNA translation in cancer.New targeted therapies for renal cell carcinoma.Mechanisms of mTOR inhibitor resistance in cancer therapy.Targeting Mnks for cancer therapy.Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.Tissue microarray evidence of association between p16 and phosphorylated eIF4E in tonsillar squamous cell carcinoma.Dual abrogation of MNK and mTOR: a novel therapeutic approach for the treatment of aggressive cancers.

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Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation

http://www.wikidata.org/entity/Q36315668

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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Inhibition of mammalian target ...... tion factor 4E phosphorylation

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Inhibition of mammalian target ...... tion factor 4E phosphorylation

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type

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Inhibition of mammalian target ...... tion factor 4E phosphorylation

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Inhibition of mammalian target ...... tion factor 4E phosphorylation

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Inhibition of mammalian target ...... tion factor 4E phosphorylation

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Molecular and Cellular Biology

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Inhibition of mammalian target ...... tion factor 4E phosphorylation

@en

P2093

Chi-Bun Chan

http://www.w3.org/2001/XMLSchema#string

Fadlo R Khuri

http://www.w3.org/2001/XMLSchema#string

Haian Fu

http://www.w3.org/2001/XMLSchema#string

Keqiang Ye

http://www.w3.org/2001/XMLSchema#string

Ping Yue

http://www.w3.org/2001/XMLSchema#string

Rie Watanabe-Fukunaga

http://www.w3.org/2001/XMLSchema#string

Rikiro Fukunaga

http://www.w3.org/2001/XMLSchema#string

Shi-Yong Sun

http://www.w3.org/2001/XMLSchema#string

Takeshi Ueda

http://www.w3.org/2001/XMLSchema#string

Xuerong Wang

http://www.w3.org/2001/XMLSchema#string

P2860

Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

The TOR pathway: a target for cancer therapy

Regulation of cap-dependent translation by eIF4E inhibitory proteins

eIF4E activity is regulated at multiple levels.

eIF4E expression in tumors: its possible role in progression of malignancies.

Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1.

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7405-7413

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10.1128/MCB.00760-07

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21

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27

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2007-08-27T00:00:00Z

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6116395

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17724079

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phosphorylation

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2169067

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