Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease
about
Proteomic Substrate Identification for Membrane Proteases in the BrainInhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism.C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer diseaseSuppression of asparaginyl endopeptidase attenuates breast cancer-induced bone pain through inhibition of neurotrophin receptors.Multifaceted Roles of Metzincins in CNS Physiology and Pathology: From Synaptic Plasticity and Cognition to Neurodegenerative DisordersAsparagine endopeptidase is an innovative therapeutic target for neurodegenerative diseases.APP Receptor? To Be or Not To Be.Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.Functions of the Alzheimer's Disease Protease BACE1 at the Synapse in the Central Nervous System.Whole exome sequence-based association analyses of plasma amyloid-β in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study.The circular RNA ciRS-7 promotes APP and BACE1 degradation in an NF-κB-dependent manner.The Role of APP in Structural Spine Plasticity.Ion channel regulation by β-secretase BACE1 - enzymatic and non-enzymatic effects beyond Alzheimer's disease.A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis.Consecutive Analysis of BACE1 Function on Developing and Developed Neuronal Cells.Not just amyloid: physiological functions of the amyloid precursor protein family.Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease.Solid-Phase Synthesis and Characterization of N-Terminally Elongated Aβ-3-x -Peptides.The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to β amyloid.APP/Aβ structural diversity and Alzheimer's disease pathogenesis.Alterations in the Balance of Amyloid-β Protein Precursor Species in the Cerebrospinal Fluid of Alzheimer's Disease Patients.Sex Differences in the Cognitive and Hippocampal Effects of Streptozotocin in an Animal Model of Sporadic AD.A meta-analysis of cerebrospinal fluid visinin-like protein-1 in alzheimers disease patients relative to healthy controls and mild cognitive impairment patients.The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer's disease.Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin.Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1.Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease.Mouse Antibody of IgM Class is Prone to Non-Enzymatic Cleavage between CH1 and CH2 Domains.Development of a smart activity-based probe to detect subcellular activity of asparaginyl endopeptidase in living cells.Tau Proteolysis in the Pathogenesis of Tauopathies: Neurotoxic Fragments and Novel Biomarkers.C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease.BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT
P2860
Q28069428-17B3316C-CFEF-41D3-8500-181AB1774FBDQ30358929-6A7BE6CC-C476-423B-BDB9-247F5BDF83E5Q33665842-459D16CD-AE23-4603-80DD-1A62F373CA63Q33740387-8D0DB3AD-1787-4BC7-B10C-C1A3375A0292Q33752135-691C2E38-CD9A-4B3D-A7F3-2188133A85E1Q33854483-4E1C2FB6-C9DE-4DD5-B57C-D54B264EB83BQ34523642-32DFE19B-CDB9-4222-9D9F-142C79AC371DQ36840033-5B1BE92F-B9A1-49F1-88B0-6DBF4065223AQ36869427-C7846516-2E51-45AD-89A3-6950D0278159Q37329676-82F4F37E-20CF-4124-8969-C3DBE26FBFBBQ38680904-34DAF2CE-1769-413F-846B-9B5B90C91812Q38712195-DBE6FCBC-4E62-498A-B8A7-038628FCB4C2Q38766310-DD391596-29AF-4C80-9467-4B85D4DF3474Q38851332-44A6A923-DF32-4A4E-9ABC-8835CE1866D3Q38913292-D2D2F8E0-A6C8-4BB5-8EA5-59E8E7E65BDAQ39051111-E2FE0FC4-90AE-4A9D-9BD5-9D2D60378EA4Q39209681-9E34777F-F079-4D0A-9C10-360FA4D940B4Q40076454-A56B6DFE-CCEA-480C-99BE-0C9FBDDFFC76Q41607465-14614E61-FE44-49D8-B576-1674B50B001FQ42778244-1980E030-FFFE-478C-BCA2-3D655C0E24F3Q46320596-BECC3C65-674C-4BD5-8759-043BA4040F51Q46390864-1E0D73BA-13F6-4E7B-8D01-A8746BB455C8Q47107171-9314276A-2FA9-4364-B621-1371D91EBAE1Q47141209-79960480-19F1-4089-BD05-1059FB4B36A8Q47204037-0E8F0742-A6F0-4F5A-9A64-A4B348CE39A2Q47592174-51A98F0A-B5AD-4602-9294-AAE3679CDB10Q47747110-F88354A3-1B08-4A7A-A476-E8F75CF03A8AQ48186447-908ADBD6-A48E-4EED-AFDB-8E58117260BCQ48262427-8D82943E-E78E-4FA3-8653-6586A93C0454Q50050844-B165CCB1-C4CF-4135-95A7-C0EA037C5823Q52598834-6D505791-F697-47B4-AB43-305EF3F0C393Q54986372-D91DBD6A-768E-4F11-9848-20A03670CD0AQ58710855-109F1550-CC54-4D81-B638-7311C472ECB2
P2860
Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
Delta-secretase cleaves amyloi ...... genesis in Alzheimer's disease
@ast
Delta-secretase cleaves amyloi ...... genesis in Alzheimer's disease
@en
type
label
Delta-secretase cleaves amyloi ...... genesis in Alzheimer's disease
@ast
Delta-secretase cleaves amyloi ...... genesis in Alzheimer's disease
@en
prefLabel
Delta-secretase cleaves amyloi ...... genesis in Alzheimer's disease
@ast
Delta-secretase cleaves amyloi ...... genesis in Alzheimer's disease
@en
P2093
P2860
P356
P1476
Delta-secretase cleaves amyloi ...... genesis in Alzheimer's disease
@en
P2093
Allan I Levey
Duc M Duong
Keqiang Ye
Liming Cheng
Mingke Song
Nicholas T Seyfried
Seong Su Kang
Shan Ping Yu
Xuebing Cao
P2860
P2888
P356
10.1038/NCOMMS9762
P407
P577
2015-11-09T00:00:00Z
P5875
P6179
1043640902