Deregulation of cyclin E in human cells interferes with prereplication complex assembly. - Wikidata - wikimedia - TriplyDB

Deregulation of cyclin E in human cells interferes with prereplication complex assembly.

Deregulation of cyclin E in human cells interferes with prereplication complex assembly.

http://www.wikidata.org/entity/Q36322482

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Repriming of DNA synthesis at stalled replication forks by human PrimPol Replication licensing and cancer--a fatal entanglement?Estrogen regulation of cyclin E2 requires cyclin D1 but not c-Myc Nascent transcription of MCM2-7 is important for nuclear localization of the minichromosome maintenance complex in G1 MMTV mouse models and the diagnostic values of MMTV-like sequences in human breast cancer CDC6: from DNA replication to cell cycle checkpoints and oncogenesis Cellular checkpoint mechanisms monitoring proper initiation of DNA replication The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles USP7 is a SUMO deubiquitinase essential for DNA replication Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions Acute reduction of an origin recognition complex (ORC) subunit in human cells reveals a requirement of ORC for Cdk2 activation.The APC/C inhibitor, Emi1, is essential for prevention of rereplication APC/C--the master controller of origin licensing?Model of DNA dynamics and replication Cyclin E overexpression impairs progression through mitosis by inhibiting APC(Cdh1).A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase.Aberrant DNA polymerase alpha is excluded from the nucleus by defective import and degradation in the nucleus Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts.Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage Differential requirements for MCM proteins in DNA replication in Drosophila S2 cells Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress.Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer Lack of CCAAT enhancer binding protein beta (C/EBPbeta) in uterine epithelial cells impairs estrogen-induced DNA replication, induces DNA damage response pathways, and promotes apoptosis.PP2A-B55β antagonizes cyclin E1 proteolysis and promotes its dysregulation in cancer.Ras activity regulates cyclin E degradation by the Fbw7 pathway.Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription Chromosome instability underlies hematopoietic stem cell dysfunction and lymphoid neoplasia associated with impaired Fbw7-mediated cyclin E regulation The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.Rescue from replication stress during mitosis.Cyclin E transgenic mice: discovery tools for lung cancer biology, therapy, and prevention.Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading.Phosphoinositide 3-kinase activation in late G1 is required for c-Myc stabilization and S phase entry Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis.Cyclin E deregulation promotes loss of specific genomic regions.Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR Abnormality in initiation program of DNA replication is monitored by the highly repetitive rRNA gene array on chromosome XII in budding yeast.The cyclin-dependent kinase inhibitor Dacapo promotes replication licensing during Drosophila endocycles.

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P2860

Deregulation of cyclin E in human cells interferes with prereplication complex assembly.

http://www.wikidata.org/entity/Q36322482

description

2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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2004年學術文章

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name

Deregulation of cyclin E in human cells interferes with prereplication complex assembly.

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Deregulation of cyclin E in human cells interferes with prereplication complex assembly.

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type

label

Deregulation of cyclin E in human cells interferes with prereplication complex assembly.

@ast

Deregulation of cyclin E in human cells interferes with prereplication complex assembly.

@en

prefLabel

Deregulation of cyclin E in human cells interferes with prereplication complex assembly.

@ast

Deregulation of cyclin E in human cells interferes with prereplication complex assembly.

@en

P1433

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Journal of Cell Biology

P1476

Deregulation of cyclin E in human cells interferes with prereplication complex assembly.

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P2093

Anders Zetterberg

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Donato Tedesco

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Steven I Reed

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Susanna Ekholm-Reed

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P2860

Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication

Conserved initiator proteins in eukaryotes

Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA

Regulation of chromosome replication

Cyclin-dependent kinases and S phase control in mammalian cells

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

Initiating DNA synthesis: from recruiting to activating the MCM complex

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789-800

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scholarly article

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10.1083/JCB.200404092

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6

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165

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Bruce William Stillman

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2004-06-14T00:00:00Z

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8510756

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15197178

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2172392

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