Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signaling - Wikidata - wikimedia - TriplyDB

Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signaling

Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signaling

http://www.wikidata.org/entity/Q36323239

about

Calpain-mediated degradation of reversibly oxidized protein-tyrosine phosphatase 1B IP-10 induces dissociation of newly formed blood vessels Structure and function of the platelet integrin alphaIIbbeta3 The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility Post-translational modification-regulated leukocyte adhesion and migration Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3 Platelet integrin alpha(IIb)beta(3): activation mechanisms Kindlin-2 controls bidirectional signaling of integrins RGT, a synthetic peptide corresponding to the integrin beta 3 cytoplasmic C-terminal sequence, selectively inhibits outside-in signaling in human platelets by disrupting the interaction of integrin alpha IIb beta 3 with Src kinase.Missense mutations in the ABCB6 transporter cause dominant familial pseudohyperkalemia.Calpain-mediated proteolysis of paxillin negatively regulates focal adhesion dynamics and cell migration.A directional switch of integrin signalling and a new anti-thrombotic strategy.Inhibition of platelet activation by peptide analogs of the beta(3)-intracellular domain of platelet integrin alpha(IIb)beta(3) conjugated to the cell-penetrating peptide Tat(48-60).Direct interaction of kindlin-3 with integrin αIIbβ3 in platelets is required for supporting arterial thrombosis in mice.Spatial coordination of kindlin-2 with talin head domain in interaction with integrin β cytoplasmic tails Calpain is required for normal osteoclast function and is down-regulated by calcitonin Evaluation of targeting c-Src by the RGT-containing peptide as a novel antithrombotic strategy.A molecular switch that controls cell spreading and retraction.The interaction of Gα13 with integrin β1 mediates cell migration by dynamic regulation of RhoA Functional Effect of the Mutations Similar to the Cleavage during Platelet Activation at Integrin β3 Cytoplasmic Tail when Expressed in Mouse Platelets Increased extracellular pressure enhances cancer cell integrin-binding affinity through phosphorylation of beta1-integrin at threonine 788/789 Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets.Mitochondrially mediated integrin αIIbβ3 protein inactivation limits thrombus growth.Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke.LFA-1 fine-tuning by cathepsin X.Model systems for platelet receptor shedding.A mutation in the β3 cytoplasmic tail causes variant Glanzmann thrombasthenia by abrogating transition of αIIb β3 to an active state.Kindlin-2 (Mig-2): a co-activator of beta3 integrins.Integrin alphaIIb-subunit cytoplasmic domain mutations demonstrate a requirement for tyrosine phosphorylation of beta3-subunits in actin cytoskeletal organization.A platelet secretion pathway mediated by cGMP-dependent protein kinase.Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domain.Cooperative role of the membrane-proximal and -distal residues of the integrin beta3 cytoplasmic domain in regulation of talin-mediated alpha IIb beta3 activation.Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition model.Fibrinogen interaction of CHO cells expressing chimeric alphaIIb/alphavbeta3 integrin.Pathological shear stress directly regulates platelet alphaIIbbeta3 signaling.Tyrosine phosphorylation of the integrin beta 3 subunit regulates beta 3 cleavage by calpain.

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P2860

Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signaling

http://www.wikidata.org/entity/Q36323239

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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2003年學術文章

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Critical roles for the COOH-te ...... e-out and outside-in signaling

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Critical roles for the COOH-te ...... e-out and outside-in signaling

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Critical roles for the COOH-te ...... e-out and outside-in signaling

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Critical roles for the COOH-te ...... e-out and outside-in signaling

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Critical roles for the COOH-te ...... e-out and outside-in signaling

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Critical roles for the COOH-te ...... e-out and outside-in signaling

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P1433

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P1433

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P1476

Critical roles for the COOH-te ...... e-out and outside-in signaling

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P2093

Richard J Bodnar

http://www.w3.org/2001/XMLSchema#string

Stephen C-T Lam

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Xiaodong Xi

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Xiaoping Du

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Zhenyu Li

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P2860

Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase

Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit

Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail

A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face

Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain

Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia

Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic

The phosphotyrosine binding-like domain of talin activates integrins

Calpain cleavage of the cytoplasmic domain of the integrin beta 3 subunit

Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation

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329-339

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10.1083/JCB.200303120

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2

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P478

162

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10661448

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12860973

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2172800

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