Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells. - Wikidata - wikimedia - TriplyDB

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells.

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells.

http://www.wikidata.org/entity/Q36323368

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RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction Mitochondria, calcium and cell death: a deadly triad in neurodegeneration Amyloidosis in Retinal Neurodegenerative Diseases The Rationale for Insulin Therapy in Alzheimer's Disease Drug Development in Alzheimer's Disease: The Contribution of PET and SPECT Killing Me Softly: Connotations to Unfolded Protein Response and Oxidative Stress in Alzheimer's Disease Alterations in Mitochondrial Quality Control in Alzheimer's Disease Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways A review on mitochondrial restorative mechanism of antioxidants in Alzheimer's disease and other neurological conditions β-Amyloid: the key peptide in the pathogenesis of Alzheimer's disease Molecular and biochemical trajectories from diabetes to Alzheimer's disease: A critical appraisal Alzheimer's pathogenesis and its link to the mitochondrion Mitochondrial dysfunction: different routes to Alzheimer's disease therapy Nuclear export of proteins and drug resistance in cancer Oxidized cholesterol as the driving force behind the development of Alzheimer's disease HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins Unfolding-resistant translocase targeting: a novel mechanism for outer mitochondrial membrane localization exemplified by the Bbeta2 regulatory subunit of protein phosphatase 2A SGTA antagonizes BAG6-mediated protein triage Mitochondria-specific accumulation of amyloid β induces mitochondrial dysfunction leading to apoptotic cell death A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine Dual targeting of antioxidant and metabolic enzymes to the mitochondrion and the apicoplast of Toxoplasma gondii Meta-analysis of the rs2075650 polymorphism and risk of Alzheimer disease.Pathogenesis of Alzheimer's disease Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease Mitochondria are related to synaptic pathology in Alzheimer's disease.Amyloid-beta and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive decline Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease Insights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data.The efficiency of protein compartmentalization into the secretory pathway.Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer's Disease.Mitochondrial DNA damage in a mouse model of Alzheimer's disease decreases amyloid beta plaque formation Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein.APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure.New Therapeutics to Modulate Mitochondrial Function in Neurodegenerative Disorders.Multiple pathogenic proteins implicated in neuronopathic Gaucher disease mice Superoxide anion, uncoupling proteins and Alzheimer's disease.Genetic variation at a single locus and age of onset for Alzheimer's disease.Convergence of amyloid-beta and tau pathologies on mitochondria in vivo.The Alzheimer's disease mitochondrial cascade hypothesis

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Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells.

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Gopa Biswas

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Hindupur K Anandatheerthavarada

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Marie-Anne Robin

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Narayan G Avadhani

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P2860

Prostate apoptosis response-4 production in synaptic compartments following apoptotic and excitotoxic insults: evidence for a pivotal role in mitochondrial dysfunction and neuronal degeneration

Targeting of NH2-terminal-processed microsomal protein to mitochondria: a novel pathway for the biogenesis of hepatic mitochondrial P450MT2

In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.

Translating cell biology into therapeutic advances in Alzheimer's disease.

Toxic neuronal apoptosis and modifications of tau and APP gene and protein expressions.

Regulation of APP cleavage by alpha-, beta- and gamma-secretases.

The processing and biological function of the human amyloid precursor protein (APP): lessons from different cellular models.

Transport of proteins into mitochondria.

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides.

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Alzheimer's disease

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2172865

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