Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis.
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Functional amyloid formation within mammalian tissue.The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and compositionAmino acid sequence determinants in self-assembly of insulin chiral amyloid superstructures: role of C-terminus of B-chain in association of fibrilsFunctions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomesEpitope mapping of the melanosomal matrix protein gp100 (PMEL17): rapid processing in the endoplasmic reticulum and glycosylation in the early Golgi compartmentThe tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesisBiogenesis and function of multivesicular bodiesMelanosomes--dark organelles enlighten endosomal membrane transportAmyloids: friend or foe?Protein Folding and Mechanisms of ProteostasisPMEL Amyloid Fibril Formation: The Bright Steps of PigmentationBLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factorPhysiological factors that regulate skin pigmentationHigh-resolution MAS NMR analysis of PI3-SH3 amyloid fibrils: backbone conformation and implications for protofilament assembly and structure .MHC class II presentation of gp100 epitopes in melanoma cells requires the function of conventional endosomes and is influenced by melanosomes.Electron tomography of early melanosomes: implications for melanogenesis and the generation of fibrillar amyloid sheets.Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and websAggregation prone regions in human proteome: Insights from large-scale data analyses.Quartz crystal microbalance studies of multilayer glucagon fibrillation at the solid-liquid interfaceThe Surprising Role of Amyloid Fibrils in HIV InfectionThe secreted form of a melanocyte membrane-bound glycoprotein (Pmel17/gp100) is released by ectodomain shedding.Ubiquitylation of a melanosomal protein by HECT-E3 ligases serves as sorting signal for lysosomal degradation.Endoplasmic reticulum export, subcellular distribution, and fibril formation by Pmel17 require an intact N-terminal domain junction.Glycoprotein nonmetastatic melanoma protein b, a melanocytic cell marker, is a melanosome-specific and proteolytically released protein.Signaling pathways in melanosome biogenesis and pathologyTwo SNPs in the SILV gene are associated with silver coat colour in ponies.Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenicKey role of CRF in the skin stress response system.Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17.The prion hypothesis: from biological anomaly to basic regulatory mechanism.Defining the limits: Protein aggregation and toxicity in vivoThe Dominant white, Dun and Smoky color variants in chicken are associated with insertion/deletion polymorphisms in the PMEL17 geneMyosin vc interacts with Rab32 and Rab38 proteins and works in the biogenesis and secretion of melanosomesRepeat domains of melanosome matrix protein Pmel17 orthologs form amyloid fibrils at the acidic melanosomal pH.Proprotein convertases process Pmel17 during secretion.Evolutionary, physicochemical, and functional mechanisms of protein homooligomerization.Reduced glutathione disrupts the intracellular trafficking of tyrosinase and tyrosinase-related protein-1 but not dopachrome tautomerase and Pmel17 to melanosomes, which results in the attenuation of melanization.Dual loss of ER export and endocytic signals with altered melanosome morphology in the silver mutation of Pmel17Structural insights into functional and pathological amyloid.Amyloidogenic properties of a D/N mutated 12 amino acid fragment of the C-terminal domain of the Cholesteryl-Ester Transfer Protein (CETP).
P2860
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P2860
Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Proprotein convertase cleavage ...... nitiate melanosome biogenesis.
@ast
Proprotein convertase cleavage ...... nitiate melanosome biogenesis.
@en
type
label
Proprotein convertase cleavage ...... nitiate melanosome biogenesis.
@ast
Proprotein convertase cleavage ...... nitiate melanosome biogenesis.
@en
prefLabel
Proprotein convertase cleavage ...... nitiate melanosome biogenesis.
@ast
Proprotein convertase cleavage ...... nitiate melanosome biogenesis.
@en
P2093
P2860
P356
P1476
Proprotein convertase cleavage ...... nitiate melanosome biogenesis.
@en
P2093
Alexander C Theos
Danielle Tenza
Dawn C Harper
Graça Raposo
Joanne F Berson
Michael S Marks
P2860
P304
P356
10.1083/JCB.200302072
P407
P50
P577
2003-05-05T00:00:00Z