Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis.
about
The major human and mouse granzymes are structurally and functionally divergentThe tumor suppressor DAL-1/4.1B and protein methylation cooperate in inducing apoptosis in MCF-7 breast cancer cells.Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737Granzyme N, a novel granzyme, is expressed in spermatocytes and spermatids of the mouse testis.The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics.Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics.Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells.Perforin rapidly induces plasma membrane phospholipid flip-flopAmplification activation loop between caspase-8 and -9 dominates artemisinin-induced apoptosis of ASTC-a-1 cells.Natural killer cells eradicate galectin-1-deficient glioma in the absence of adaptive immunity.Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis.Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes.Artemisinin induces A549 cell apoptosis dominantly via a reactive oxygen species-mediated amplification activation loop among caspase-9, -8 and -3.IκΒα inhibits apoptosis at the outer mitochondrial membrane independently of NF-κB retention.Toxoplasma gondii inhibits granzyme B-mediated apoptosis by the inhibition of granzyme B function in host cellsLive cell evaluation of granzyme delivery and death receptor signaling in tumor cells targeted by human natural killer cellsHuman and murine granzyme B exhibit divergent substrate preferencesFarnesylthiosalicylic acid sensitizes hepatocarcinoma cells to artemisinin derivatives.Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis.Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner.Mechanisms of granule-dependent killing.Immunological control of herpes simplex virus infections.Perforin and Fas act together in the induction of apoptosis, and both are critical in the clearance of lymphocytic choriomeningitis virus infection.Protection against CD95-induced apoptosis by chlamydial infection at a mitochondrial step.Real-time detection of CTL function reveals distinct patterns of caspase activation mediated by Fas versus granzyme B.De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF.Granzyme B of cytotoxic T cells induces extramitochondrial reactive oxygen species production via caspase-dependent NADPH oxidase activation.Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs.Serpins prevent granzyme-induced death in a species-specific manner.Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells.Targeting and amplification of immune killing of tumor cells by pro-Smac.Suppression of granzyme B activity and caspase-3 activation in leukaemia cells constitutively expressing the protease inhibitor 9.Caspase-dependent cytochrome c release and cell death in chick cardiomyocytes after simulated ischemia-reperfusion.Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events.A central role for Bid in granzyme B-induced apoptosis.Disruption of Mcl-1.Bim complex in granzyme B-mediated mitochondrial apoptosis.A novel mechanism for protein delivery: granzyme B undergoes electrostatic exchange from serglycin to target cells.Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity.HIV gp41-induced apoptosis is mediated by caspase-3-dependent mitochondrial depolarization, which is inhibited by HIV protease inhibitor nelfinavir.Blockade of BAFF Receptor BR3 on T Cells Enhances Their Activation and Cytotoxicity.
P2860
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P2860
Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
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2003年學術文章
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name
Granzyme B activates procaspas ...... on loop for maximal apoptosis.
@ast
Granzyme B activates procaspas ...... on loop for maximal apoptosis.
@en
type
label
Granzyme B activates procaspas ...... on loop for maximal apoptosis.
@ast
Granzyme B activates procaspas ...... on loop for maximal apoptosis.
@en
prefLabel
Granzyme B activates procaspas ...... on loop for maximal apoptosis.
@ast
Granzyme B activates procaspas ...... on loop for maximal apoptosis.
@en
P2093
P2860
P356
P1476
Granzyme B activates procaspas ...... on loop for maximal apoptosis.
@en
P2093
Baikun Wang
Christopher J Froelich
Michelle L Ebbs
Srikumar M Raja
Sunil S Metkar
Yong J Lee
P2860
P304
P356
10.1083/JCB.200210158
P407
P577
2003-03-10T00:00:00Z