The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics.
about
A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentationDynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase.Granzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis.Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis.Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening.Tubulin proteomics: towards breaking the code.Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics.Technical variability is greater than biological variability in a microarray experiment but both are outweighed by changes induced by stimulation.Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B.Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouseIntracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.Human and murine granzyme B exhibit divergent substrate preferencesImmunohistochemical and ultrastructural study of the lamellae of oocytes in atretic follicles in relation to different processes of cell death.Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population.Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal.Targets of caspase-6 activity in human neurons and Alzheimer disease.Mechanisms of granule-dependent killing.Serine protease HtrA1 associates with microtubules and inhibits cell migration.Mechanisms of ketamine-involved regulation of cytochrome P450 gene expression.Orphan granzymes find a home.Non-cytotoxic antiviral activities of granzymes in the context of the immune antiviral state.Cell death-independent functions of granzymes: hit viruses where it hurts.Imaging the microanatomy of astrocyte-T-cell interactions in immune-mediated inflammation.Emerging roles of apoptotic microtubules during the execution phase of apoptosis.Keratins: Biomarkers and modulators of apoptotic and necrotic cell death in the liver.JWA enhances As₂O₃-induced tubulin polymerization and apoptosis via p38 in HeLa and MCF-7 cells.hSMG-1 is a granzyme B-associated stress-responsive protein kinase.Granzyme B of cytotoxic T cells induces extramitochondrial reactive oxygen species production via caspase-dependent NADPH oxidase activation.Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs.Analysis of protein processing by N-terminal proteomics reveals novel species-specific substrate determinants of granzyme B orthologs.Hip is a pro-survival substrate of granzyme B.Hop cleavage and function in granzyme B-induced apoptosis.Design and characterization of a novel human Granzyme B inhibitor.Infiltrating CTLs in human glioblastoma establish immunological synapses with tumorigenic cells.Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A.Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity.Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway.Antigen-specific primed cytotoxic T cells eliminate tumour cells in vivo and prevent tumour development, regardless of the presence of anti-apoptotic mutations conferring drug resistance.Proteomic analysis through larval development of Solea senegalensis flatfish.
P2860
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P2860
The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics.
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
The cytotoxic lymphocyte prote ...... ubule polymerization dynamics.
@ast
The cytotoxic lymphocyte prote ...... ubule polymerization dynamics.
@en
type
label
The cytotoxic lymphocyte prote ...... ubule polymerization dynamics.
@ast
The cytotoxic lymphocyte prote ...... ubule polymerization dynamics.
@en
prefLabel
The cytotoxic lymphocyte prote ...... ubule polymerization dynamics.
@ast
The cytotoxic lymphocyte prote ...... ubule polymerization dynamics.
@en
P2093
P2860
P356
P1476
The cytotoxic lymphocyte prote ...... ubule polymerization dynamics.
@en
P2093
Gabriela Brumatti
Patrick J Duriez
Petrina Delivani
P2860
P304
P356
10.1074/JBC.M509361200
P407
P577
2006-01-16T00:00:00Z