Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport.
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NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growthRole of phosphorylation on the structural dynamics and function of types III and IV intermediate filamentsDysfunctions of neuronal and glial intermediate filaments in diseaseIntermediate Filaments as Organizers of Cellular Space: How They Affect Mitochondrial Structure and FunctionPost-translational modifications of intermediate filament proteins: mechanisms and functionsMyosin Va increases the efficiency of neurofilament transport by decreasing the duration of long-term pauses.The polymer brush model of neurofilament projections: effect of protein composition.Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression.Altered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALS.The C-terminal domains of NF-H and NF-M subunits maintain axonal neurofilament content by blocking turnover of the stationary neurofilament networkAxonal pathology precedes demyelination in a mouse model of X-linked demyelinating/type I Charcot-Marie Tooth neuropathy.Dissociation of Axonal Neurofilament Content from Its Transport RateNeurofilament Phosphorylation during Development and Disease: Which Came First, the Phosphorylation or the Accumulation?Failure of lower motor neuron radial outgrowth precedes retrograde degeneration in a feline model of spinal muscular atrophy.Expansion of neurofilament medium C terminus increases axonal diameter independent of increases in conduction velocity or myelin thickness.Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death.The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate.Neurofilaments at a glance.Regulation of neurofilament dynamics by phosphorylation.Providing cellular signposts--post-translational modifications of intermediate filaments.MSC p43 required for axonal development in motor neurons.Phosphorylation of highly conserved neurofilament medium KSP repeats is not required for myelin-dependent radial axonal growthTargeted inactivation of a developmentally regulated neural plectin isoform (plectin 1c) in mice leads to reduced motor nerve conduction velocityNeurofilament phosphorylation and their proline-directed kinases in health and disease.Neurofilament dynamics and involvement in neurological disorders.Specialized roles of neurofilament proteins in synapses: Relevance to neuropsychiatric disorders.Lessons from Animal Models of Cytoplasmic Intermediate Filament Proteins.Neurofilaments and Neurofilament Proteins in Health and Disease.The polypeptide composition of moving and stationary neurofilaments in cultured sympathetic neuronsNeurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments.Phosphorylation of the head domain of neurofilament protein (NF-M): a factor regulating topographic phosphorylation of NF-M tail domain KSP sites in neurons.Developmental pattern of the neuronal intermediate filament inaa in the zebrafish retina.LEDGFp52 controls rat retinal ganglion cell neurite growth in culture and regulates specific neuronal growth-associated genes and protein production.Expression of medium and heavy chain neurofilaments in the developing human auditory cortex.Alterations in neurofilament protein(s) in human leprous nerves: morphology, immunohistochemistry and Western immunoblot correlative study.
P2860
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P2860
Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
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2002年學術文章
@zh-hant
name
Gene replacement in mice revea ...... goes in slow axonal transport.
@ast
Gene replacement in mice revea ...... goes in slow axonal transport.
@en
type
label
Gene replacement in mice revea ...... goes in slow axonal transport.
@ast
Gene replacement in mice revea ...... goes in slow axonal transport.
@en
prefLabel
Gene replacement in mice revea ...... goes in slow axonal transport.
@ast
Gene replacement in mice revea ...... goes in slow axonal transport.
@en
P2093
P2860
P356
P1476
Gene replacement in mice revea ...... rgoes in slow axonal transport
@en
P2093
Aidong Yuan
Chris M Ward
Michael L Garcia
Nigel A Calcutt
Ralph A Nixon
Salvatore Mattina
Takahiro Gotow
Yasuo Uchiyama
Yukio Miyazaki
P2860
P304
P356
10.1083/JCB.200202037
P407
P577
2002-08-19T00:00:00Z