3alpha-hydroxy-5alpha-pregnan-20-one in the midbrain ventral tegmental area mediates social, sexual, and affective behaviors
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Neurosteroids' effects and mechanisms for social, cognitive, emotional, and physical functionsAlteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolaseBeyond the HPA Axis: Progesterone-Derived Neuroactive Steroids in Human Stress and EmotionSteroid modulation of GABAA receptor-mediated transmission in the hypothalamus: effects on reproductive function.Contrasting effects of increased and decreased dopamine transmission on latent inhibition in ovariectomized rats and their modulation by 17beta-estradiol: an animal model of menopausal psychosis?Estrogen is necessary for 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) infusion to the ventral tegmental area to facilitate social and sexual, but neither exploratory nor affective behavior of ovariectomized rats.Corticosteroid and neurosteroid dysregulation in an animal model of autism, BTBR mice.Female mice with deletion of Type One 5α-reductase have reduced reproductive responding during proestrus and after hormone-primingPrenatal Stress Alters Progestogens to Mediate Susceptibility to Sex-Typical, Stress-Sensitive Disorders, such as Drug Abuse: A Review.Novel substrates for, and sources of, progestogens for reproduction.Oxytocin increases VTA activation to infant and sexual stimuli in nulliparous and postpartum womenEffects and Mechanisms of 3α,5α,-THP on Emotion, Motivation, and Reward Functions Involving Pregnane Xenobiotic Receptor.Neurotoxicity by synthetic androgen steroids: oxidative stress, apoptosis, and neuropathology: A review.Progesterone can enhance consolidation and/or performance in spatial, object and working memory tasks in Long-Evans rats.Progesterone turnover to its 5α-reduced metabolites in the ventral tegmental area of the midbrain is essential for initiating social and affective behavior and progesterone metabolism in female rats.Role of 5-HT(1A) receptors in fluoxetine-induced lordosis inhibition.Role of androgens in epilepsy.Progestins influence motivation, reward, conditioning, stress, and/or response to drugs of abuse.6-hydroxydopamine lesions enhance progesterone-facilitated lordosis of rats and hamsters, independent of effects on motor behavior.Progestin concentrations are increased following paced mating in midbrain, hippocampus, diencephalon, and cortex of rats in behavioral estrus, but only in midbrain of diestrous ratsFluoxetine-induced decrements in sexual responses of female rats and hamsters are reversed by 3α,5α-THP.Effects of neurosteroid actions at N-methyl-D-aspartate and GABA A receptors in the midbrain ventral tegmental area for anxiety-like and mating behavior of female rats.Effects of manipulating progesterone and NMDA receptors in the ventral tegmental area for lordosis of hamsters and rats.The use of the elevated plus maze as an assay of anxiety-related behavior in rodentsOvarian steroids enhance object recognition in naturally cycling and ovariectomized, hormone-primed ratsKetogenic diet decreases circulating concentrations of neuroactive steroids of female rats.GABA(A) receptor neurotransmission dysfunction in a mouse model of social isolation-induced stress: possible insights into a non-serotonergic mechanism of action of SSRIs in mood and anxiety disorders.Membrane actions of progestins at dopamine type 1-like and GABAA receptors involve downstream signal transduction pathways.Estrous cycle, pregnancy, and parity enhance performance of rats in object recognition or object placement tasks.Conjugated equine estrogen enhances rats' cognitive, anxiety, and social behaviorIn the ventral tegmental area, progestogens' membrane-mediated actions for lordosis of rats involve the second-messenger phospholipase C.Exploratory, anti-anxiety, social, and sexual behaviors of rats in behavioral estrus is attenuated with inhibition of 3alpha,5alpha-THP formation in the midbrain ventral tegmental area.Infusions of 3alpha,5alpha-THP to the VTA enhance exploratory, anti-anxiety, social, and sexual behavior and increase levels of 3alpha,5alpha-THP in midbrain, hippocampus, diencephalon, and cortex of female rats.Activity of protein kinase C is important for 3alpha,5alpha-THP's actions at dopamine type 1-like and/or GABAA receptors in the ventral tegmental area for lordosis of rats.Female gonadal hormones, mild restraint, and male preferenceProgesterone reduces depression-like behavior in a murine model of Alzheimer's Disease.Social closeness increases salivary progesterone in humans.Estradiol enhances sociosexual behavior and can have proliferative effects in ovariectomized ratsInfusions of bicuculline to the ventral tegmental area attenuates sexual, exploratory, and anti-anxiety behavior of proestrous rats.Increasing 3alpha,5alpha-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats.
P2860
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P2860
3alpha-hydroxy-5alpha-pregnan-20-one in the midbrain ventral tegmental area mediates social, sexual, and affective behaviors
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
3alpha-hydroxy-5alpha-pregnan- ...... exual, and affective behaviors
@ast
3alpha-hydroxy-5alpha-pregnan- ...... exual, and affective behaviors
@en
type
label
3alpha-hydroxy-5alpha-pregnan- ...... exual, and affective behaviors
@ast
3alpha-hydroxy-5alpha-pregnan- ...... exual, and affective behaviors
@en
prefLabel
3alpha-hydroxy-5alpha-pregnan- ...... exual, and affective behaviors
@ast
3alpha-hydroxy-5alpha-pregnan- ...... exual, and affective behaviors
@en
P2093
P2860
P1433
P1476
3alpha-hydroxy-5alpha-pregnan- ...... exual, and affective behaviors
@en
P2093
P2860
P304
P356
10.1016/J.NEUROSCIENCE.2005.06.015
P407
P577
2005-12-01T00:00:00Z