Opposing actions of Arx and Pax4 in endocrine pancreas development - Wikidata - wikimedia - TriplyDB

Opposing actions of Arx and Pax4 in endocrine pancreas development

Opposing actions of Arx and Pax4 in endocrine pancreas development

http://www.wikidata.org/entity/Q36336824

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Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells MafB is required for islet beta cell maturation Genome-edited human stem cell-derived beta cells: a powerful tool for drilling down on type 2 diabetes GWAS biology Multipotent pancreas progenitors: Inconclusive but pivotal topic Pancreatic stem cells remain unresolved Reprogramming pancreatic cells to β cells From Beta cell replacement to beta cell regeneration: implications for antidiabetic therapy Maintenance of β-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology Elimination of von Hippel-Lindau function perturbs pancreas endocrine homeostasis in mice Pancreatic α-cell specific deletion of mouse Arx leads to α-cell identity loss The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells Transcription factor regulation of pancreatic organogenesis, differentiation and maturation Epigenetic Regulation of Islet Development and Regeneration Arx is required for normal enteroendocrine cell development in mice and humans High-throughput analysis of promoter occupancy reveals new targets for Arx, a gene mutated in mental retardation and interneuronopathies Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse A regulatory path associated with X-linked intellectual disability and epilepsy links KDM5C to the polyalanine expansions in ARX Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3 Expression of Groucho/TLE proteins during pancreas development The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation The genetic architecture of type 2 diabetes Adult tissue sources for new β cells.Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract A triplet repeat expansion genetic mouse model of infantile spasms syndrome, Arx(GCG)10+7, with interneuronopathy, spasms in infancy, persistent seizures, and adult cognitive and behavioral impairment Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females.Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development.Analysis of beta-cell gene expression reveals inflammatory signaling and evidence of dedifferentiation following human islet isolation and culture Secreted factors from olfactory mucosa cells expanded as free-floating spheres increase neurogenesis in olfactory bulb neurosphere cultures Expression of zebrafish pax6b in pancreas is regulated by two enhancers containing highly conserved cis-elements bound by PDX1, PBX and PREP factors SEL1L deficiency impairs growth and differentiation of pancreatic epithelial cells.Relative roles of the different Pax6 domains for pancreatic alpha cell development.

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P2860

Opposing actions of Arx and Pax4 in endocrine pancreas development

http://www.wikidata.org/entity/Q36336824

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2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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2003年學術文章

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Opposing actions of Arx and Pax4 in endocrine pancreas development

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Opposing actions of Arx and Pax4 in endocrine pancreas development

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Genes & Development

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Opposing actions of Arx and Pax4 in endocrine pancreas development

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P2093

Ahmed Mansouri

http://www.w3.org/2001/XMLSchema#string

Gerard Gradwohl

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Jacob Hecksher-Sorensen

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Jens Krull

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Palle Serup

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Patrick Collombat

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Peter Gruss

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P2860

neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS

A novel human homeobox gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

Positioning of five genes (CASK, ARX, SAT, IMAGE cDNAs 248928 and 253949) from the human X chromosome short arm with respect to evolutionary breakpoints on the mouse X chromosome

Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans

Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells

Notch signalling controls pancreatic cell differentiation

Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells

Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9

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2591-2603

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10.1101/GAD.269003

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20

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17

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9048345

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14561778

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Aizkuņģa dziedzeris

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218152

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