Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory. - Wikidata - wikimedia - TriplyDB

Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory.

Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory.

http://www.wikidata.org/entity/Q36340852

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Secretory IgA: Designed for Anti-Microbial Defense Life of T follicular helper cells Memory B cells in transplantation CD73 expression is dynamically regulated in the germinal center and bone marrow plasma cells are diminished in its absence Heterogeneity of B Cell Functions in Stroke-Related Risk, Prevention, Injury, and Repair Hydroxypropyl-β-cyclodextrin spikes local inflammation that induces Th2 cell and T follicular helper cell responses to the coadministered antigen.Protective neutralizing influenza antibody response in the absence of T follicular helper cells.Digital cell quantification identifies global immune cell dynamics during influenza infection Rationale for B cell targeting in SLE Modification of the respiratory syncytial virus f protein in virus-like particles impacts generation of B cell memory.Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells.Memory B cells.Lasting antibody responses are mediated by a combination of newly formed and established bone marrow plasma cells drawn from clonally distinct precursors Functional capacities of human IgM memory B cells in early inflammatory responses and secondary germinal center reactions Class-switched memory B cells remodel BCRs within secondary germinal centers.Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cells Cutting edge: T follicular helper cell differentiation is defective in the absence of Bcl6 BTB repressor domain function.Rapid Proliferation and Differentiation of a Subset of Circulating IgM Memory B Cells to a CpG/Cytokine Stimulus In Vitro LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6 Distinct germinal center selection at local sites shapes memory B cell response to viral escape Cutting Edge: CTLA-4Ig Inhibits Memory B Cell Responses and Promotes Allograft Survival in Sensitized Recipients.Bcl6 middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3.Cellular Dynamics of Memory B Cell Populations: IgM+ and IgG+ Memory B Cells Persist Indefinitely as Quiescent Cells.A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells.Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response.Lower IgG somatic hypermutation rates during acute dengue virus infection is compatible with a germinal center-independent B cell response.Secretory immunity with special reference to the oral cavity.CD4 memory T cells develop and acquire functional competence by sequential cognate interactions and stepwise gene regulation Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation.T cell-dependent IgM memory B cells generated during bacterial infection are required for IgG responses to antigen challenge.Targeting antigens to CD180 rapidly induces antigen-specific IgG, affinity maturation, and immunological memory.Reversing endogenous alloreactive B cell GC responses with anti-CD154 or CTLA-4Ig.Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection.Both mutated and unmutated memory B cells accumulate mutations in the course of the secondary response and develop a new antibody repertoire optimally adapted to the secondary stimulus.Somatically Hypermutated Plasmodium-Specific IgM(+) Memory B Cells Are Rapid, Plastic, Early Responders upon Malaria Rechallenge Mouse model for acute Epstein-Barr virus infection.Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer.Identification of microRNAs implicated in the late differentiation stages of normal B cells suggests a central role for miRNA targets ZEB1 and TP53 Memory B cells in mouse models.What is and what should always have been: long-lived plasma cells induced by T cell-independent antigens.

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Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory.

http://www.wikidata.org/entity/Q36340852

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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Distinct cellular pathways sel ...... ies into immunological memory.

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Distinct cellular pathways sel ...... ies into immunological memory.

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Distinct cellular pathways sel ...... ies into immunological memory.

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Distinct cellular pathways sel ...... ies into immunological memory.

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Distinct cellular pathways sel ...... ies into immunological memory.

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Journal of Experimental Medicine

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Distinct cellular pathways sel ...... dies into immunological memory

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Akiko Ishige

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Atsushi Hijikata

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Junko Taka

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Mariko Okada

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Masaki Hikida

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Masato Kubo

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Takeshi Nagashima

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Tomohiro Kaji

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Tomohiro Kurosaki

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Toshitada Takemori

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P2860

The NR4A subgroup: immediate early response genes with pleiotropic physiological roles

Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo

Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis

Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells

The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

Control of inflammation, cytokine expression, and germinal center formation by BCL-6

The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation

Follicular helper CD4 T cells (TFH)

Visualizing spatiotemporal dynamics of multicellular cell-cycle progression

Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter.

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2079-2097

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10.1084/JEM.20120127

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11

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209

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Yoshimasa Takahashi

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2012-10-01T00:00:00Z

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231742544

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23027924

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3478929

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