TREM2 regulates microglial cell activation in response to demyelination in vivo.
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Phagocytosis of apoptotic cells in homeostasisTREM2 mRNA Expression in Leukocytes Is Increased in Alzheimer's Disease and Schizophrenia.Functional Cooperativity between ABCG4 and ABCG1 Isoforms.TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearanceThe endocytic pathway in microglia during health, aging and Alzheimer's disease.A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosisMicroglial malfunction: the third rail in the development of Alzheimer's disease.The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes.Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status.A cord blood monocyte-derived cell therapy product accelerates brain remyelinationDifferential burden of rare protein truncating variants in Alzheimer's disease patients compared to centenarians.Electroacupuncture Promotes Remyelination after Cuprizone Treatment by Enhancing Myelin Debris Clearance.Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.TREM2 in Neurodegenerative Diseases.TREM2-Ligand Interactions in Health and Disease.Heterozygote galactocerebrosidase (GALC) mutants have reduced remyelination and impaired myelin debris clearance following demyelinating injury.Astrocyte-targeted production of interleukin-6 reduces astroglial and microglial activation in the cuprizone demyelination model: Implications for myelin clearance and oligodendrocyte maturation.Divergent Neuroinflammatory Regulation of Microglial TREM Expression and Involvement of NF-κB.Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target.Defective Phagocytic Corpse Processing Results in Neurodegeneration and Can Be Rescued by TORC1 ActivationProtective and Pathological Immunity during Central Nervous System Infections.Myelin as an inflammatory mediator: Myelin interactions with complement, macrophages, and microglia in spinal cord injury.Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages.TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway.Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging.Erythromyeloid-Derived TREM2: A Major Determinant of Alzheimer's Disease Pathology in Down Syndrome.Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes.Differential contribution of microglia and monocytes in neurodegenerative diseases.Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis.Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945.Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?Heterozygous carriers of galactocerebrosidase mutations that cause Krabbe disease have impaired microglial function and defective repair of myelin damage.Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination.Targeting microglia for the treatment of Alzheimer's Disease.Distinct Gene Profiles of Bone Marrow-Derived Macrophages and Microglia During Neurotropic Coronavirus-Induced Demyelination.Chronic stress as a risk factor for Alzheimer's disease: Roles of microglia-mediated synaptic remodeling, inflammation, and oxidative stress.Microglia in Alzheimer's diseaseInflammation as a central mechanism in Alzheimer's diseaseThe Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans
P2860
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P2860
TREM2 regulates microglial cell activation in response to demyelination in vivo.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
TREM2 regulates microglial cell activation in response to demyelination in vivo.
@ast
TREM2 regulates microglial cell activation in response to demyelination in vivo.
@en
type
label
TREM2 regulates microglial cell activation in response to demyelination in vivo.
@ast
TREM2 regulates microglial cell activation in response to demyelination in vivo.
@en
prefLabel
TREM2 regulates microglial cell activation in response to demyelination in vivo.
@ast
TREM2 regulates microglial cell activation in response to demyelination in vivo.
@en
P2093
P2860
P50
P921
P1476
TREM2 regulates microglial cell activation in response to demyelination in vivo.
@en
P2093
Bryan Bollman
Carla M Yuede
Claudia Cantoni
Danilo Licastro
Karel Otero
Laura Piccio
Mingqiang Xie
Robert Mikesell
Robert Schmidt
Robyn S Klein
P2860
P2888
P304
P356
10.1007/S00401-015-1388-1
P577
2015-01-29T00:00:00Z