UNC-60B, an ADF/cofilin family protein, is required for proper assembly of actin into myofibrils in Caenorhabditis elegans body wall muscle.
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Nemaline myopathy with minicores caused by mutation of the CFL2 gene encoding the skeletal muscle actin-binding protein, cofilin-2The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamicsTropomyosin inhibits ADF/cofilin-dependent actin filament dynamicsImmunological responses and actin dynamics in macrophages are controlled by N-cofilin but are independent from ADFAip1 destabilizes cofilin-saturated actin filaments by severing and accelerating monomer dissociation from ends.A widespread distribution of genomic CeMyoD binding sites revealed and cross validated by ChIP-Chip and ChIP-Seq techniquesA comparative structural analysis of the ADF/cofilin familyStructural conservation between the actin monomer-binding sites of twinfilin and actin-depolymerizing factor (ADF)/cofilinSolution structure and dynamics of ADF from Toxoplasma gondiiCofilin-1 and Other ADF/Cofilin Superfamily Members in Human Malignant CellsMuscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegansActin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells.Normal myofibrillar development followed by progressive sarcomeric disruption with actin accumulations in a mouse Cfl2 knockout demonstrates requirement of cofilin-2 for muscle maintenanceMutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopeniaAberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethalityThe RNA-binding protein SUP-12 controls muscle-specific splicing of the ADF/cofilin pre-mRNA in C. elegansActin depolymerizing factor stabilizes an existing state of F-actin and can change the tilt of F-actin subunitsToxoplasma gondii actin depolymerizing factor acts primarily to sequester G-actin.The Caenorhabditis elegans unc-78 gene encodes a homologue of actin-interacting protein 1 required for organized assembly of muscle actin filaments.ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo.Two actin-interacting protein 1 isoforms function redundantly in the somatic gonad and are essential for reproduction in Caenorhabditis elegansHuman cofilin forms oligomers exhibiting actin bundling activity.The C-terminal tail of UNC-60B (actin depolymerizing factor/cofilin) is critical for maintaining its stable association with F-actin and is implicated in the second actin-binding site.Aggregation of actin and cofilin in identical twins with juvenile-onset dystonia.Control of actin dynamics in cell motility. Role of ADF/cofilin.Characterization of human muscle type cofilin (CFL2) in normal and regenerating muscle.Regulation of structure and function of sarcomeric actin filaments in striated muscle of the nematode Caenorhabditis elegans.Dynamic regulation of sarcomeric actin filaments in striated muscleTropomyosin and troponin are required for ovarian contraction in the Caenorhabditis elegans reproductive system.Enhancement of actin-depolymerizing factor/cofilin-dependent actin disassembly by actin-interacting protein 1 is required for organized actin filament assembly in the Caenorhabditis elegans body wall muscleCaenorhabditis elegans kettin, a large immunoglobulin-like repeat protein, binds to filamentous actin and provides mechanical stability to the contractile apparatuses in body wall muscle.Solution structures and dynamics of ADF/cofilins UNC-60A and UNC-60B from Caenorhabditis elegansThe two actin-interacting protein 1 genes have overlapping and essential function for embryonic development in Caenorhabditis elegansUnusual regulation of splicing of the cholinergic locus in Caenorhabditis elegans.Dual roles of tropomyosin as an F-actin stabilizer and a regulator of muscle contraction in Caenorhabditis elegans body wall muscleBiochemical and cell biological analysis of actin in the nematode Caenorhabditis elegansNMR assignments of actin depolymerizing factor (ADF) like UNC-60A and cofilin like UNC-60B proteins of Caenorhabditis elegansThe two Caenorhabditis elegans actin-depolymerizing factor/cofilin proteins differently enhance actin filament severing and depolymerizationStructural components of the nonstriated contractile apparatuses in the Caenorhabditis elegans gonadal myoepithelial sheath and their essential roles for ovulation.unc-94 encodes a tropomodulin in Caenorhabditis elegans.
P2860
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P2860
UNC-60B, an ADF/cofilin family protein, is required for proper assembly of actin into myofibrils in Caenorhabditis elegans body wall muscle.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
UNC-60B, an ADF/cofilin family ...... itis elegans body wall muscle.
@ast
UNC-60B, an ADF/cofilin family ...... itis elegans body wall muscle.
@en
type
label
UNC-60B, an ADF/cofilin family ...... itis elegans body wall muscle.
@ast
UNC-60B, an ADF/cofilin family ...... itis elegans body wall muscle.
@en
prefLabel
UNC-60B, an ADF/cofilin family ...... itis elegans body wall muscle.
@ast
UNC-60B, an ADF/cofilin family ...... itis elegans body wall muscle.
@en
P2860
P356
P1476
UNC-60B, an ADF/cofilin family ...... itis elegans body wall muscle.
@en
P2093
D L Baillie
G M Benian
P2860
P304
P356
10.1083/JCB.145.3.491
P407
P577
1999-05-01T00:00:00Z