Ir gene function in an I-A subregion mutant B6.C-H-2bm12.
about
Shared T cell recognition sites on human histocompatibility leukocyte antigen class II molecules of patients with seropositive rheumatoid arthritis.Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alphaImmune response gene function correlates with the expression of an Ia antigen. I. Preferential association of certain Ae and E alpha chains results in a quantitative deficiency in expression of an Ae:E alpha complex.Immune response gene function correlates with the expression of an Ia antigen. II. A quantitative deficiency in Ae:E alpha complex expression causes a corresponding defect in antigen-presenting cell function.Inhibition of antigen-specific T lymphocyte activation by structurally related Ir gene-controlled polymers. Evidence of specific competition for accessory cell antigen presentationSerologic and functional characterization of a panel of antigen-presenting cell lines expressing mutant I-A class II moleculesGene conversion between murine class II major histocompatibility complex loci. Functional and molecular evidence from the bm 12 mutant.Thymus dictates major histocompatibility complex (MHC) specificity and immune response gene phenotype of class II MHC-restricted T cells but not of class I MHC-restricted T cells.A class II gene conversion event defines an antigen-specific Ir gene epitope.Molecular genetic analysis of 178 I-Abm12-reactive T cellsThe contribution of mutant amino acids to alloantigenicity.DNA sequence analysis of I-Ak beta mutants reveals serologically immunodominant region.Selective loss of antigen-specific Ir gene function in IA mutant B6.C-H-2bm12 is an antigen presenting cell defect.The murine bm12 gene conversion provides evidence that T cells recognize predominantly Ia conformation."Exon-shuffling" maps control of antibody- and T-cell-recognition sites to the NH2-terminal domain of the class II major histocompatibility polypeptide A beta.Dendritic cells and antigen presentation in the regulation of cytotoxic T lymphocyte responses against viruses and transplantation antigens.A hypothetical model of the foreign antigen binding site of class II histocompatibility molecules.Structure and polymorphism of murine and human class II major histocompatibility antigens.Gain/loss of poly(Glu50Tyr50)/poly(Glu60Ala30Tyr10) responsiveness in the bm12 mutant strainBiochemical characterization of a second family of human Ia molecules, HLA-DS, equivalent to murine I-A subregion moleculesThe influence of MHC gene products on the generation of an antigen-specific T-cell repertoire.
P2860
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P2860
Ir gene function in an I-A subregion mutant B6.C-H-2bm12.
description
1981 nî lūn-bûn
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1981年の論文
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1981年学术文章
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1981年学术文章
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name
Ir gene function in an I-A subregion mutant B6.C-H-2bm12.
@ast
Ir gene function in an I-A subregion mutant B6.C-H-2bm12.
@en
type
label
Ir gene function in an I-A subregion mutant B6.C-H-2bm12.
@ast
Ir gene function in an I-A subregion mutant B6.C-H-2bm12.
@en
prefLabel
Ir gene function in an I-A subregion mutant B6.C-H-2bm12.
@ast
Ir gene function in an I-A subregion mutant B6.C-H-2bm12.
@en
P2093
P2860
P356
P1476
Ir gene function in an I-A subregion mutant B6.C-H-2bm12.
@en
P2093
McKenzie IF
Melvold RW
Michaelides M
P2860
P304
P356
10.1084/JEM.153.2.464
P407
P577
1981-02-01T00:00:00Z