Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion
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The functional significance of the skeletal muscle clock: lessons from Bmal1 knockout modelsSleep, circadian dysrhythmia, obesity and diabetesTargeting of the circadian clock via CK1δ/ε to improve glucose homeostasis in obesityCircadian Rhythms in Gastrointestinal Health and DiseasesCooperative roles of the suprachiasmatic nucleus central clock and the adrenal clock in controlling circadian glucocorticoid rhythm.Clock Gene Dysregulation Induced by Chronic ER Stress Disrupts β-cell Function.Dopamine D2 receptors and the circadian clock reciprocally mediate antipsychotic drug-induced metabolic disturbances.The Role of the Molecular Clock in Skeletal Muscle and What It Is Teaching Us About Muscle-Bone Crosstalk.Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cellsHypophysectomy abolishes rhythms in rat thyroid hormones but not in the thyroid clockA class of circadian long non-coding RNAs mark enhancers modulating long-range circadian gene regulation.Uncoupling protein 2 regulates daily rhythms of insulin secretion capacity in MIN6 cells and isolated islets from male miceCLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial.Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes.Taurine Treatment Modulates Circadian Rhythms in Mice Fed A High Fat Diet.Deletion of histone deacetylase 3 in adult beta cells improves glucose tolerance via increased insulin secretion.Rodent Models for the Analysis of Tissue Clock Function in Metabolic Rhythms Research.Survival and growth of C57BL/6J mice lacking the BK channel, Kcnma1: lower adult body weight occurs together with higher body fat.Modulation of learning and memory by the targeted deletion of the circadian clock gene Bmal1 in forebrain circuits.MicroRNAs modulate core-clock gene expression in pancreatic islets during early postnatal life in rats.Defining a Novel Role for the PDX1 Transcription Factor in Islet β Cell Maturation and Proliferation During Weaning.Circadian variation of the pancreatic islet transcriptome.Clock genes and salt-sensitive hypertension: a new type of aldosterone-synthesizing enzyme controlled by the circadian clock and angiotensin II.Pancreatic α- and β-cellular clocks have distinct molecular properties and impact on islet hormone secretion and gene expression.Mechanisms of β-cell functional adaptation to changes in workloadCircadian time signatures of fitness and disease.Transcriptional architecture of the mammalian circadian clock.Unique Aspects of Cryptochrome in Chronobiology and Metabolism, Pancreatic β-Cell Dysfunction, and Regeneration: Research into Cysteine414-Alanine Mutant CRY1.Timing of meals: when is as critical as what and how much.The circadian clock, metabolism and obesity.Genomics of Islet (Dys)function and Type 2 Diabetes.Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures.Meal Timing Regulates the Human Circadian System.Bmal1 regulates inflammatory responses in macrophages by modulating enhancer RNA transcription.Role of clock genes in insulin secretion.Alpha TC1 and Beta-TC-6 genomic profiling uncovers both shared and distinct transcriptional regulatory features with their primary islet counterparts.High-Resolution Recording of the Circadian Oscillator in Primary Mouse α- and β-Cell Culture.A functional circadian clock is required for proper insulin secretion by human pancreatic islet cells.Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro.The polymorphism of rs266729 in adiponectin gene and type 2 diabetes mellitus: A Meta-Analysis.
P2860
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P2860
Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion
description
2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
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2015年學術文章
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name
Pancreatic β cell enhancers re ...... controlling insulin secretion
@ast
Pancreatic β cell enhancers re ...... controlling insulin secretion
@en
type
label
Pancreatic β cell enhancers re ...... controlling insulin secretion
@ast
Pancreatic β cell enhancers re ...... controlling insulin secretion
@en
prefLabel
Pancreatic β cell enhancers re ...... controlling insulin secretion
@ast
Pancreatic β cell enhancers re ...... controlling insulin secretion
@en
P2093
P2860
P356
P1433
P1476
Pancreatic β cell enhancers re ...... controlling insulin secretion
@en
P2093
Aaron R Dinner
Akihiko Taguchi
Amanda L Allred
Biliana Marcheva
Chiaki Omura
Christopher A Bradfield
Clara Bien Peek
Grant D Barish
Heekyung Hong
Joseph Bass
P2860
P304
P356
10.1126/SCIENCE.AAC4250
P407
P577
2015-11-01T00:00:00Z